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The map label for this gene is mrdA [H]

Identifier: 53717825

GI number: 53717825

Start: 187471

End: 189927

Strand: Reverse

Name: mrdA [H]

Synonym: BPSL0183

Alternate gene names: 53717825

Gene position: 189927-187471 (Counterclockwise)

Preceding gene: 53717826

Following gene: 53717824

Centisome position: 4.66

GC content: 68.82

Gene sequence:

>2457_bases
ATGACCGAATTCAAGGACACACAACAGCAGCTCTCGAAGTTCCGCCTGCGCGTCGCGGCGGCGGGCGTGTTCGTGTTCGT
CTGCTTCGGCCTGCTCGCCACGCGGTTCTTCTACCTCCAGGTCTGGCAGCACGGCAAGTACGCGCTGCAGGCCGAGGAGA
ACCGGATCTCGGTCGCCCCGATCGTCCCGAACCGCGGGATCATCACCGATCGCAACGGCGTCGTGCTCGCGAAGAACTAC
TCCGCGTACACGCTCGAGATCACACCGTCGAAGCTCGCCGACACACTCGACAACACGATCAACGCGCTCGCCGAGGTCGT
GCAGATCGACGCGCGCGACCGCCGCCGCTTCAAGAAGCTGCAGGAGGACTCGAAGAATTTCGAGAGCCTGCCGATCCGCA
CGCGCCTCACCGACGACGAAGTCGCGCGCTTTACCGCGCAGCGCTGGCGCTTTCCGGGCGTCGACGTGCGCGCGCGCCTG
TTCCGCCAATATCCGCTCGGCCCGACGGCCGCGCATGTGATCGGCTACATCGGCCGGATCTCGAAGCGCGATCAGGACCG
GATCGACGCGATGAGCGACGAGAACGACAGCGATCCGGAAACCTACGACCCGCGGCGCGACGCGAACAACTACAAGGGCA
CCGACTACATCGGCAAGGTCGGCGTCGAGCAAAGCTACGAAACCGAGCTGCACGGCATCACCGGCTTCGAGGAAGTCGAG
GTGACGGCGGGCGGGCGGCCCGTGCGCACGCTGTCGCGCACGCAGGCGACGCCCGGCAGCAACCTCGTGCTGTCGCTCGA
CATCGGGTTGCAGCAGGTTGCCGAGCAGGCATTCGCCGGCAAACGCGGCGCGCTCGTCGCGATCGAGCCGAAGACGGGCG
ACGTGCTCGCGTTCGTGTCGTCGCCGAGCTTCGACCCGAACTCGTTCGTCGACGGCATCGACCAGCAGACCTGGGACGAG
CTCAACAACTCGCCCGACAAGCCGCTGCTGAACCGGCCGCTGCACGGCACCTATCCGCCCGGCTCGACGTACAAGCCGTT
CATGGCGCTCGCCGGCCTCGCGCTCGGCAAGCGCACGCCGGGCTGGGGCTTCCAGGACCCCGGCTACTTCACGTTCGGCG
GCCACACGTTCCGCAACGACGTGCGCTCGGGCCAGGGCTGGGTCGACATGAACAAGGCGATCATGGTGTCGAACGACACG
TACTTCTACATGCTCGCGCGCGACCTTGGCGTGACCGCGATCGCGAACTTCATGAAGCCGTTCGGCTTCGGCCAGCTGAC
GGGCATCGACATCCAGGGCGAGGCGCGCGGGATCCTGCCGTCGCCCGAATGGAAGAAGAAGACGTTCAAGAAGGCCGCTC
AGCAGAAATGGTTCGACGGCGAGACGATCAGTCTCGGGATCGGCCAGGGCTACAACTCGTTCACGATCCTGCAGCTCGCG
CACGCGACGGCCACGCTCGCGAACGACGGCGTGATCATGAAGCCGCACCTCGTGAAGGAAGTCGAGAACCCGATCTCGCG
CGCGCGGCACCTGACGGTGCCGAAGGAAAGCGGCGTGATTCCGCTCAAGCAGAACGATCTCGACGTCGTGAAGCGCGGGA
TGGAGAACGTCGTCGAAAGCCCGTCCGGCACCGCGTTCAAGGTGTTCCGCGGCGCGCCATACCTCGCGGCCGGCAAGACC
GGCACCGCGCAGGTGTTCTCGCTGCAGGGCGGCAACTACCGCGGCCACCTGCTCGCCGAGCATCTGCGCGACCACGCGCT
GTTCATCGCGTACGCGCCCGTCGACCATCCGCAGATCGCACTTGCGCTGATCGTCGAGAACGGCGGCTGGGGCGCGCAGT
CGGCGGGCCCGATCGCGCGGCGCGTGCTCGATTTCTACCTGCTCGAGCGCAAGAATCCGTCGACGGAAGCGGCGGCCGTC
GCGGCGGCCGCGTCGGCGACCGAGCCCGTGAACGCACCCGTGATCGGCGACGCGACGAAGCCTGTCGGCATCGCGGCCGG
GTTCAAGGCGCTGCCGCAACCGATGCCGCTCGCGTCGGCAAGCGGCGCGGACGGCGCATCAGGCGCATCAGGCGCATCAG
GCGCATCAGGCGCATCAGGCGCATCAGGCGCATCGGGCGCGGGCGGGGAGCCGACGGAGCACGCAAACGCGGGAGGAAAC
TCGGCCGGCGGCGGCATTGCAGGGGGCGCGGCCGGCACGGCGAACAACGGATCGGGCGCCGCGGCCCCGGGCGGCATGCC
CGGCGCGAACGGCGCGGCAACGGGCGCGCCGCCCGCATCCCGCCGCCTGCCGCCGCGCAAGCCGCGCCGCACGCCGGCGA
GCGACGCGGCGATCAGCGCCGCCGCATCGCGGGACGACCCGCGCAAACCCTCATCGGGCGCCCCGAAGACACCCGCTCAG
GACGACAACCATGCCGTCTCCGCCGCCAGGCCGGCGGCGGGCGGCATCGACGAGTAA

Upstream 100 bases:

>100_bases
GCCGCGCGGGCGGCCCGCCCGGCCGGGGCGACGCACGCGCCTCGCCCCGGCGCGAGCCCGCCCGCGCGGCGTCGAAAGCG
CGCTCTCCATCCGTAATCGC

Downstream 100 bases:

>100_bases
CGGAGACAGGCATGCAATTCGACAAGCGCGCCTCGCTCGACAAGATCAAGCAGATGTTCGCGGGCTTCGACCGGCCGCTC
GCGCTCATCGTGTTCCTGCT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 818; Mature: 817

Protein sequence:

>818_residues
MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNY
SAYTLEITPSKLADTLDNTINALAEVVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRWRFPGVDVRARL
FRQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDENDSDPETYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLALGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGILPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANDGVIMKPHLVKEVENPISRARHLTVPKESGVIPLKQNDLDVVKRGMENVVESPSGTAFKVFRGAPYLAAGKT
GTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLERKNPSTEAAAV
AAAASATEPVNAPVIGDATKPVGIAAGFKALPQPMPLASASGADGASGASGASGASGASGASGASGAGGEPTEHANAGGN
SAGGGIAGGAAGTANNGSGAAAPGGMPGANGAATGAPPASRRLPPRKPRRTPASDAAISAAASRDDPRKPSSGAPKTPAQ
DDNHAVSAARPAAGGIDE

Sequences:

>Translated_818_residues
MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNY
SAYTLEITPSKLADTLDNTINALAEVVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRWRFPGVDVRARL
FRQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDENDSDPETYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDE
LNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLALGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDT
YFYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGILPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
HATATLANDGVIMKPHLVKEVENPISRARHLTVPKESGVIPLKQNDLDVVKRGMENVVESPSGTAFKVFRGAPYLAAGKT
GTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLERKNPSTEAAAV
AAAASATEPVNAPVIGDATKPVGIAAGFKALPQPMPLASASGADGASGASGASGASGASGASGASGAGGEPTEHANAGGN
SAGGGIAGGAAGTANNGSGAAAPGGMPGANGAATGAPPASRRLPPRKPRRTPASDAAISAAASRDDPRKPSSGAPKTPAQ
DDNHAVSAARPAAGGIDE
>Mature_817_residues
TEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAPIVPNRGIITDRNGVVLAKNYS
AYTLEITPSKLADTLDNTINALAEVVQIDARDRRRFKKLQEDSKNFESLPIRTRLTDDEVARFTAQRWRFPGVDVRARLF
RQYPLGPTAAHVIGYIGRISKRDQDRIDAMSDENDSDPETYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVEV
TAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVSSPSFDPNSFVDGIDQQTWDEL
NNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLALGKRTPGWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTY
FYMLARDLGVTAIANFMKPFGFGQLTGIDIQGEARGILPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLAH
ATATLANDGVIMKPHLVKEVENPISRARHLTVPKESGVIPLKQNDLDVVKRGMENVVESPSGTAFKVFRGAPYLAAGKTG
TAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIALALIVENGGWGAQSAGPIARRVLDFYLLERKNPSTEAAAVA
AAASATEPVNAPVIGDATKPVGIAAGFKALPQPMPLASASGADGASGASGASGASGASGASGASGAGGEPTEHANAGGNS
AGGGIAGGAAGTANNGSGAAAPGGMPGANGAATGAPPASRRLPPRKPRRTPASDAAISAAASRDDPRKPSSGAPKTPAQD
DNHAVSAARPAAGGIDE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=645, Percent_Identity=40, Blast_Score=467, Evalue=1e-132,
Organism=Escherichia coli, GI1786272, Length=639, Percent_Identity=23.1611893583725, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 86744; Mature: 86613

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLADTLDNTINALAEVVQIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDDEVARFTAQRWRFPGVDVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDENDSDPETYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
CCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLALGKRTP
CCCCCCHHHHHCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVTAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHHHHHHHHHHHH
FGFGQLTGIDIQGEARGILPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANDGVIMKPHLVKEVENPISRARHLTVPKESGVIPLKQNDLDVVKRGMENVVES
HHHHHHCCCCEEECHHHHHHHHHHHHHHHEECCCCCCCEEEECCCCHHHHHHHHHHHHCC
PSGTAFKVFRGAPYLAAGKTGTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARRVLDFYLLERKNPSTEAAAVAAAASATEPVNAPVIGDATK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCC
PVGIAAGFKALPQPMPLASASGADGASGASGASGASGASGASGASGAGGEPTEHANAGGN
CCCHHHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAGGGIAGGAAGTANNGSGAAAPGGMPGANGAATGAPPASRRLPPRKPRRTPASDAAISA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHH
AASRDDPRKPSSGAPKTPAQDDNHAVSAARPAAGGIDE
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEFKDTQQQLSKFRLRVAAAGVFVFVCFGLLATRFFYLQVWQHGKYALQAEENRISVAP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEE
IVPNRGIITDRNGVVLAKNYSAYTLEITPSKLADTLDNTINALAEVVQIDARDRRRFKKL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QEDSKNFESLPIRTRLTDDEVARFTAQRWRFPGVDVRARLFRQYPLGPTAAHVIGYIGRI
HHHCCCHHCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SKRDQDRIDAMSDENDSDPETYDPRRDANNYKGTDYIGKVGVEQSYETELHGITGFEEVE
CCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHCCCCCCCEEE
VTAGGRPVRTLSRTQATPGSNLVLSLDIGLQQVAEQAFAGKRGALVAIEPKTGDVLAFVS
EECCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEC
SPSFDPNSFVDGIDQQTWDELNNSPDKPLLNRPLHGTYPPGSTYKPFMALAGLALGKRTP
CCCCCCHHHHHCCCHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GWGFQDPGYFTFGGHTFRNDVRSGQGWVDMNKAIMVSNDTYFYMLARDLGVTAIANFMKP
CCCCCCCCEEEECCHHHHHHHCCCCCEEECCCEEEEECCCEEEEEEHHHHHHHHHHHHHH
FGFGQLTGIDIQGEARGILPSPEWKKKTFKKAAQQKWFDGETISLGIGQGYNSFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEH
HATATLANDGVIMKPHLVKEVENPISRARHLTVPKESGVIPLKQNDLDVVKRGMENVVES
HHHHHHCCCCEEECHHHHHHHHHHHHHHHEECCCCCCCEEEECCCCHHHHHHHHHHHHCC
PSGTAFKVFRGAPYLAAGKTGTAQVFSLQGGNYRGHLLAEHLRDHALFIAYAPVDHPQIA
CCCCEEEEECCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCEE
LALIVENGGWGAQSAGPIARRVLDFYLLERKNPSTEAAAVAAAASATEPVNAPVIGDATK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEECCCCC
PVGIAAGFKALPQPMPLASASGADGASGASGASGASGASGASGASGAGGEPTEHANAGGN
CCCHHHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SAGGGIAGGAAGTANNGSGAAAPGGMPGANGAATGAPPASRRLPPRKPRRTPASDAAISA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHH
AASRDDPRKPSSGAPKTPAQDDNHAVSAARPAAGGIDE
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]