BacMap

Definition	Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome.
Accession	NC_002942
Length	3,397,754

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The map label for this gene is legP

Identifier: 52843192

GI number: 52843192

Start: 3391003

End: 3391803

Strand: Direct

Name: legP

Synonym: lpg2999

Alternate gene names: NA

Gene position: 3391003-3391803 (Clockwise)

Preceding gene: 52843190

Following gene: NA

Centisome position: 99.8

GC content: 38.08

Gene sequence:

>801_bases
ATGAAAACTAAATCATGGATTGCCAGTTTGTTTTATTCCTCATTATGTTTCTCCTCTTCTTACGCAATTAATCTCCATCA
AATCACAATAACTGATCCAATAATGGGCAGTCGTACCATTACCTATGAACAAGTTGGAGAATTTGCAGTAGTGGAAGGTG
ATATTTTGATTGGTAAAGCAGAGAATCTTAAAAACCAAGGTGCTGTTATTACACCAAAAGTAGGAGGTTCACGCTGGCCA
AATGGTGTTATCCCTTATGAAATTGCTGAAAATTTACCTTTTATAAACAAGCTTGCCATTTTACAAGCAATAGATCATTG
GCAGAAAAACACGAATTTAGAATTCGTTGAATTAACTTCTAAAAATCGCTATGACTATCGTGATTACATTTCTTTTATCC
CGGCAGAAGGCACAACCTGCTCTTCCTACGTTGGACGCCAGGGAGGGAAGCAAGAGATCAATTTGGCGCCAAGATGTACT
ACCATGAATACGGTACATGAAATAGGACATGCCTTGGGCATGTGGCATGAGCAATCCCGATCAGACAGAAATCAATATAT
TCGTATCGTCTGGGAAAATATTGATGAAGAACATAAATTTAATTTTGACCAACATTTAACTGATGGGAAAGATTTCGGTG
AATACGACTATGGATCCATTATGCATTATGGTCGATTTGCTTTTTCCAAGAATGGTCAGCCAACTATCATACCTCTAGTT
GATGGAGTTGAAATAGGGCAGCGAACTCATTTAAGTGAAAAAGATATCGCTGCCGTCAAAGCAATGTACCCTGAAACCTA
A

Upstream 100 bases:

>100_bases
TAAGGTTATCAAGAGTCAACAAACTATATAAAAAGTTCTGGAAATCTACTCCCTCTTTCCCCTAAACTGTCCTTGGTTTT
TTTAGACTTAAGGACTATAT

Downstream 100 bases:

>100_bases
TTGGGAGTGGCTAAGGCCATATATCCATCCTTTTCCTCTGAAGGAGCGGCTAAAGCCAACTGTTTGGCCGCTTTCGCTTC
AGAGTGTTGGTCATAAGCAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKTKSWIASLFYSSLCFSSSYAINLHQITITDPIMGSRTITYEQVGEFAVVEGDILIGKAENLKNQGAVITPKVGGSRWP
NGVIPYEIAENLPFINKLAILQAIDHWQKNTNLEFVELTSKNRYDYRDYISFIPAEGTTCSSYVGRQGGKQEINLAPRCT
TMNTVHEIGHALGMWHEQSRSDRNQYIRIVWENIDEEHKFNFDQHLTDGKDFGEYDYGSIMHYGRFAFSKNGQPTIIPLV
DGVEIGQRTHLSEKDIAAVKAMYPET

Sequences:

>Translated_266_residues
MKTKSWIASLFYSSLCFSSSYAINLHQITITDPIMGSRTITYEQVGEFAVVEGDILIGKAENLKNQGAVITPKVGGSRWP
NGVIPYEIAENLPFINKLAILQAIDHWQKNTNLEFVELTSKNRYDYRDYISFIPAEGTTCSSYVGRQGGKQEINLAPRCT
TMNTVHEIGHALGMWHEQSRSDRNQYIRIVWENIDEEHKFNFDQHLTDGKDFGEYDYGSIMHYGRFAFSKNGQPTIIPLV
DGVEIGQRTHLSEKDIAAVKAMYPET
>Mature_266_residues
MKTKSWIASLFYSSLCFSSSYAINLHQITITDPIMGSRTITYEQVGEFAVVEGDILIGKAENLKNQGAVITPKVGGSRWP
NGVIPYEIAENLPFINKLAILQAIDHWQKNTNLEFVELTSKNRYDYRDYISFIPAEGTTCSSYVGRQGGKQEINLAPRCT
TMNTVHEIGHALGMWHEQSRSDRNQYIRIVWENIDEEHKFNFDQHLTDGKDFGEYDYGSIMHYGRFAFSKNGQPTIIPLV
DGVEIGQRTHLSEKDIAAVKAMYPET

Specific function: Zinc metallendopeptidase that cleaves preferentially on amino-terminal side of aspartate-containing substrates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ricin B-type lectin domain [H]

Homologues:

Organism=Homo sapiens, GI157502169, Length=223, Percent_Identity=36.7713004484305, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI5453579, Length=194, Percent_Identity=41.2371134020619, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4502421, Length=194, Percent_Identity=41.2371134020619, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI22547221, Length=217, Percent_Identity=39.1705069124424, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI6912724, Length=194, Percent_Identity=40.7216494845361, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI153070264, Length=221, Percent_Identity=37.10407239819, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI153070262, Length=223, Percent_Identity=35.8744394618834, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71989620, Length=189, Percent_Identity=39.6825396825397, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71981168, Length=224, Percent_Identity=36.1607142857143, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71986189, Length=189, Percent_Identity=40.2116402116402, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25152806, Length=193, Percent_Identity=38.3419689119171, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71995692, Length=188, Percent_Identity=37.7659574468085, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI115532764, Length=191, Percent_Identity=40.3141361256544, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25149641, Length=209, Percent_Identity=34.4497607655502, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71981193, Length=252, Percent_Identity=31.3492063492063, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980967, Length=229, Percent_Identity=32.3144104803493, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983097, Length=229, Percent_Identity=31.0043668122271, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989946, Length=172, Percent_Identity=42.4418604651163, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71989942, Length=172, Percent_Identity=42.4418604651163, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17568533, Length=186, Percent_Identity=34.9462365591398, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25150905, Length=193, Percent_Identity=37.3056994818653, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71996019, Length=228, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71986142, Length=174, Percent_Identity=32.183908045977, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI193210526, Length=170, Percent_Identity=35.8823529411765, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534131, Length=167, Percent_Identity=37.7245508982036, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983649, Length=191, Percent_Identity=36.6492146596859, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983640, Length=191, Percent_Identity=37.17277486911, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71996833, Length=192, Percent_Identity=36.4583333333333, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI86562912, Length=189, Percent_Identity=33.8624338624339, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71996558, Length=222, Percent_Identity=32.8828828828829, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71996566, Length=222, Percent_Identity=32.8828828828829, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32566667, Length=193, Percent_Identity=34.7150259067358, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71991562, Length=172, Percent_Identity=34.8837209302326, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25149215, Length=193, Percent_Identity=34.7150259067358, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71993705, Length=166, Percent_Identity=34.3373493975904, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509235, Length=192, Percent_Identity=29.6875, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI72000269, Length=165, Percent_Identity=33.9393939393939, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645453, Length=183, Percent_Identity=32.2404371584699, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71993835, Length=199, Percent_Identity=31.6582914572864, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17568805, Length=201, Percent_Identity=28.3582089552239, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI115532766, Length=98, Percent_Identity=43.8775510204082, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562122, Length=205, Percent_Identity=28.2926829268293, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355491, Length=227, Percent_Identity=39.647577092511, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI20129545, Length=196, Percent_Identity=43.3673469387755, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24649626, Length=232, Percent_Identity=38.7931034482759, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24643089, Length=234, Percent_Identity=35.8974358974359, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24644493, Length=227, Percent_Identity=35.6828193832599, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19921386, Length=272, Percent_Identity=32.7205882352941, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI19921382, Length=237, Percent_Identity=37.9746835443038, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI19921388, Length=190, Percent_Identity=38.9473684210526, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136740, Length=194, Percent_Identity=39.6907216494845, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24649765, Length=194, Percent_Identity=39.6907216494845, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI19921390, Length=203, Percent_Identity=35.4679802955665, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921384, Length=225, Percent_Identity=34.6666666666667, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45549230, Length=194, Percent_Identity=35.0515463917526, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646966, Length=213, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001506
- InterPro:   IPR006026
- InterPro:   IPR008997
- InterPro:   IPR000772 [H]

Pfam domain/function: PF01400 Astacin; PF00652 Ricin_B_lectin [H]

EC number: =3.4.24.76 [H]

Molecular weight: Translated: 30181; Mature: 30181

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKSWIASLFYSSLCFSSSYAINLHQITITDPIMGSRTITYEQVGEFAVVEGDILIGKA
CCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEHHHHCCEEEEECCEEEECH
ENLKNQGAVITPKVGGSRWPNGVIPYEIAENLPFINKLAILQAIDHWQKNTNLEFVELTS
HCCCCCCCEEEECCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
KNRYDYRDYISFIPAEGTTCSSYVGRQGGKQEINLAPRCTTMNTVHEIGHALGMWHEQSR
CCCCCHHHHHHEECCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
SDRNQYIRIVWENIDEEHKFNFDQHLTDGKDFGEYDYGSIMHYGRFAFSKNGQPTIIPLV
CCCCCEEEEEECCCCHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHEEECCCCCEEEEEEE
DGVEIGQRTHLSEKDIAAVKAMYPET
CCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTKSWIASLFYSSLCFSSSYAINLHQITITDPIMGSRTITYEQVGEFAVVEGDILIGKA
CCHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEHHHHCCEEEEECCEEEECH
ENLKNQGAVITPKVGGSRWPNGVIPYEIAENLPFINKLAILQAIDHWQKNTNLEFVELTS
HCCCCCCCEEEECCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
KNRYDYRDYISFIPAEGTTCSSYVGRQGGKQEINLAPRCTTMNTVHEIGHALGMWHEQSR
CCCCCHHHHHHEECCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
SDRNQYIRIVWENIDEEHKFNFDQHLTDGKDFGEYDYGSIMHYGRFAFSKNGQPTIIPLV
CCCCCEEEEEECCCCHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHEEECCCCCEEEEEEE
DGVEIGQRTHLSEKDIAAVKAMYPET
CCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7771796; 7768917 [H]