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The map label for this gene is ksgA

Identifier: 52843122

GI number: 52843122

Start: 3314290

End: 3315060

Strand: Reverse

Name: ksgA

Synonym: lpg2928

Alternate gene names: 52843122

Gene position: 3315060-3314290 (Counterclockwise)

Preceding gene: 52843126

Following gene: 52843121

Centisome position: 97.57

GC content: 38.39

Gene sequence:

>771_bases
GTGAGGCATAGCCCACGTAAACGTTTTGGTCAAAATTTCTTACAAGACAAATATATTATTAATGAGATTCTACGCGCTAT
CAATCCTTTGGCGGATGATAATATGCTGGAGATTGGCCCTGGTTTAGGCGCTTTAACTCAGCCATTATTGCAAAAACTGA
ATCAATTAACAGCCATTGAAATCGATACGGATTTACAAAGCTATTTAACCTGCTTGCCTGCATCTCAAGGCAAACTGAAT
TTAATTCCTGCTGATGCGTTAACCGTTGACTTTTGTCAATTCGGCCCCCATTTAAGAGTAGTGGGTAATTTACCTTATAA
TATTTCTACTCCATTGCTGATCTATTTATTGAAATTTATAACTTGTATTGATGACATGCATTTTATGTTACAAAAAGAAG
TTGTAGAACGAATAGCAGCAGCCCACGGCACTAAAGCCTATGGGCGACTAAGCGTGATGTTGCAGTATCATTGTGAGGTA
GAGTATTTATTTGATGTTCCTCCAGAAGCGTTTGAGCCCAGGCCCAAGGTAGACTCAGCAATAGTTCGATTAACACCTTA
TCGTGTTTCGCCATTTGAGTCTGTAAACACTGAGAAACTGGAAAATATTGTTGCTAAAGCATTTGCTATGAGACGCAAAA
CTCTTACTAATAATTTGAAAGGGATTATCTCATTATCTCAACTCAATGATTTAGGCATTGATGGAGGTAAGCGGCCAGAA
CAAATTTCGGTGGCGGAATATGTCCAACTAGCGAAATTTATTTCCAATTAG

Upstream 100 bases:

>100_bases
CTAACCTACGGTAAAATTAACAGGCTTCCCCAAATGGGGTATACCTTGTGATGTCAACAAGATTACTGAATTAATTTTAT
CCTAACATAGGTGATAGAAA

Downstream 100 bases:

>100_bases
TGTAAAATTATATGATAAGTTATTGTGGAGGTTGTCTTGTTTCATCGTCAGCGTAAAAGCTCTATATCTGCTCAGTCCAA
GTCATTAAAAGATTTAATCC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MRHSPRKRFGQNFLQDKYIINEILRAINPLADDNMLEIGPGLGALTQPLLQKLNQLTAIEIDTDLQSYLTCLPASQGKLN
LIPADALTVDFCQFGPHLRVVGNLPYNISTPLLIYLLKFITCIDDMHFMLQKEVVERIAAAHGTKAYGRLSVMLQYHCEV
EYLFDVPPEAFEPRPKVDSAIVRLTPYRVSPFESVNTEKLENIVAKAFAMRRKTLTNNLKGIISLSQLNDLGIDGGKRPE
QISVAEYVQLAKFISN

Sequences:

>Translated_256_residues
MRHSPRKRFGQNFLQDKYIINEILRAINPLADDNMLEIGPGLGALTQPLLQKLNQLTAIEIDTDLQSYLTCLPASQGKLN
LIPADALTVDFCQFGPHLRVVGNLPYNISTPLLIYLLKFITCIDDMHFMLQKEVVERIAAAHGTKAYGRLSVMLQYHCEV
EYLFDVPPEAFEPRPKVDSAIVRLTPYRVSPFESVNTEKLENIVAKAFAMRRKTLTNNLKGIISLSQLNDLGIDGGKRPE
QISVAEYVQLAKFISN
>Mature_256_residues
MRHSPRKRFGQNFLQDKYIINEILRAINPLADDNMLEIGPGLGALTQPLLQKLNQLTAIEIDTDLQSYLTCLPASQGKLN
LIPADALTVDFCQFGPHLRVVGNLPYNISTPLLIYLLKFITCIDDMHFMLQKEVVERIAAAHGTKAYGRLSVMLQYHCEV
EYLFDVPPEAFEPRPKVDSAIVRLTPYRVSPFESVNTEKLENIVAKAFAMRRKTLTNNLKGIISLSQLNDLGIDGGKRPE
QISVAEYVQLAKFISN

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=281, Percent_Identity=33.0960854092527, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI7657198, Length=219, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786236, Length=257, Percent_Identity=50.1945525291829, Blast_Score=255, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI25146882, Length=210, Percent_Identity=34.7619047619048, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25141369, Length=244, Percent_Identity=29.0983606557377, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324989, Length=218, Percent_Identity=26.605504587156, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358017, Length=218, Percent_Identity=34.8623853211009, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357273, Length=287, Percent_Identity=29.616724738676, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 28814; Mature: 28814

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHSPRKRFGQNFLQDKYIINEILRAINPLADDNMLEIGPGLGALTQPLLQKLNQLTAIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEE
IDTDLQSYLTCLPASQGKLNLIPADALTVDFCQFGPHLRVVGNLPYNISTPLLIYLLKFI
ECHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHH
TCIDDMHFMLQKEVVERIAAAHGTKAYGRLSVMLQYHCEVEYLFDVPPEAFEPRPKVDSA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEECCCEEEEECCCCHHCCCCCCCCCC
IVRLTPYRVSPFESVNTEKLENIVAKAFAMRRKTLTNNLKGIISLSQLNDLGIDGGKRPE
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCC
QISVAEYVQLAKFISN
CCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRHSPRKRFGQNFLQDKYIINEILRAINPLADDNMLEIGPGLGALTQPLLQKLNQLTAIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEE
IDTDLQSYLTCLPASQGKLNLIPADALTVDFCQFGPHLRVVGNLPYNISTPLLIYLLKFI
ECHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHH
TCIDDMHFMLQKEVVERIAAAHGTKAYGRLSVMLQYHCEVEYLFDVPPEAFEPRPKVDSA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEECCCEEEEECCCCHHCCCCCCCCCC
IVRLTPYRVSPFESVNTEKLENIVAKAFAMRRKTLTNNLKGIISLSQLNDLGIDGGKRPE
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCC
QISVAEYVQLAKFISN
CCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA