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The map label for this gene is legU2

Identifier: 52843026

GI number: 52843026

Start: 3201113

End: 3201853

Strand: Reverse

Name: legU2

Synonym: lpg2830

Alternate gene names: 52843026

Gene position: 3201853-3201113 (Counterclockwise)

Preceding gene: 52843028

Following gene: 52843025

Centisome position: 94.23

GC content: 35.09

Gene sequence:

>741_bases
TTGGGGTATAGAATAGAAATGGCGACACGAAATCCTTTTGATATTGATCATAAAAGTAAATACTTAAGAGAAGCAGCATT
AGAGGCCAATTTATCTCATCCAGAAACAACACCAACAATGCTGACTTGCCCTATTGACAGCGGATTTCTAAAAGATCCCG
TGATCACACCAGAAGGTTTTGTTTATAATAAATCCTCTATTTTAAAATGGTTAGAAACGAAAAAAGAAGACCCACAAAGC
CGTAAACCCTTAACGGCTAAAGATTTGCAACCATTCCCCGAGTTATTGATTATAGTCAATAGATTTGTTGAGACACAAAC
GAACTATGAAAAATTAAAAAACAGATTAGTGCAAAATGCTCGGGTTGCTGCACGCCAAAAAGAATACACTGAAATTCCGG
ATATATTTCTTTGCCCAATAAGTAAAACGCTTATCAAAACACCTGTCATTACTGCCCAAGGGAAAGTATATGATCAAGAA
GCATTAAGTAACTTTCTTATCGCAACGGGTAATAAAGATGAAACAGGCAAAAAATTATCCATTGATGATGTAGTGGTGTT
TGATGAACTCTATCAACAGATAAAAGTTTATAATTTTTACCGCAAACGCGAAATGCAAAAAAATCAAATTCAACCTTCAG
TAAGTAGTGGTTTTGGCTTTTTTAGCTTGAATTTTCTCACCTCATGGTTATGGGGAACTGAGGAGAAAAAAGAAAAGACA
TCATCTGATATGACGTACTAA

Upstream 100 bases:

>100_bases
TCTTTATTAGCGAAAGCACAAATAATGAAGGAGTGATTCACCTATAAAACAAATAAATTGCATAAAAATAAATCTAATGG
TAAAATATTGCATCATTTAG

Downstream 100 bases:

>100_bases
TGCCCCGTTTTTGCGCAATATTGATTCAAAGTGAAGTAAATTTTGAGAGAAAAAACCACTATACTGGCATGAATCAACTA
TATTAATAATATAGATTGTT

Product: UBOX-containing protein

Products: NA

Alternate protein names: Legionella U-box protein

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MGYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKWLETKKEDPQS
RKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQE
ALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREMQKNQIQPSVSSGFGFFSLNFLTSWLWGTEEKKEKT
SSDMTY

Sequences:

>Translated_246_residues
MGYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKWLETKKEDPQS
RKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQE
ALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREMQKNQIQPSVSSGFGFFSLNFLTSWLWGTEEKKEKT
SSDMTY
>Mature_245_residues
GYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKWLETKKEDPQSR
KPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQEA
LSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREMQKNQIQPSVSSGFGFFSLNFLTSWLWGTEEKKEKTS
SDMTY

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Acts in conjunction with host E2 ubiquitin-conjugating enzy

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell. Note=Secreted via type IV secretion system (T4SS), and delivered into the host cell

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 U-box domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LUBX_LEGPH (Q5ZRQ0)

Other databases:

- EMBL:   AE017354
- RefSeq:   YP_096825.1
- ProteinModelPortal:   Q5ZRQ0
- STRING:   Q5ZRQ0
- GeneID:   3079841
- GenomeReviews:   AE017354_GR
- KEGG:   lpn:lpg2830
- NMPDR:   fig|272624.3.peg.2770
- eggNOG:   NOG133361
- HOGENOM:   HBG520503
- OMA:   TEIPDIF
- ProtClustDB:   CLSK738037
- BioCyc:   LPNE272624:LPG2830-MONOMER
- GO:   GO:0009405
- InterPro:   IPR003613
- InterPro:   IPR013083
- Gene3D:   G3DSA:3.30.40.10
- SMART:   SM00504

Pfam domain/function: PF04564 U-box

EC number: NA

Molecular weight: Translated: 28412; Mature: 28281

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGF
CCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
VYNKSSILKWLETKKEDPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNA
EECHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQEALSNFLIATGNKDETGKKLS
HHHHHHHHHHCCCCEEECCCHHHHHHCCCEECCCCEECHHHHHCEEEECCCCCCCCCEEC
IDDVVVFDELYQQIKVYNFYRKREMQKNQIQPSVSSGFGFFSLNFLTSWLWGTEEKKEKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEHHHHHHHHCCCHHHHHHH
SSDMTY
HCCCCC
>Mature Secondary Structure 
GYRIEMATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGF
CEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
VYNKSSILKWLETKKEDPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNA
EECHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
RVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQEALSNFLIATGNKDETGKKLS
HHHHHHHHHHCCCCEEECCCHHHHHHCCCEECCCCEECHHHHHCEEEECCCCCCCCCEEC
IDDVVVFDELYQQIKVYNFYRKREMQKNQIQPSVSSGFGFFSLNFLTSWLWGTEEKKEKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEHHHHHHHHCCCHHHHHHH
SSDMTY
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA