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The map label for this gene is folP [H]

Identifier: 52842992

GI number: 52842992

Start: 3148032

End: 3148907

Strand: Reverse

Name: folP [H]

Synonym: lpg2795

Alternate gene names: 52842992

Gene position: 3148907-3148032 (Counterclockwise)

Preceding gene: 52842993

Following gene: 52842991

Centisome position: 92.68

GC content: 39.84

Gene sequence:

>876_bases
GTGAATTCTGAACAGTTCCTCGGTTGGCTTGAGCGAAAGAGCCAACCTCCTTCCTCCTTGGTTTTTGAAAAGCCATTAAT
TATGGGTGTGTTAAATGTTACCTCGGACTCATTTTATGATGGTGGCAAGTATCTGTCTGTTGATAGCGCCTGTGATCAGG
CCTTAAAATTAATTGCATGTGGAGCTGATCTCATTGATATTGGTGGGGAATCAACCAAACCTGGTGCTCCCCCAGTCCCT
TTAGATGTTGAACTATCAAGAGTTCTTCCCGTAATCAAACAACTTCGTGTCCTCGCAGATGTGTGTATTTCTATTGATAC
TAATAAGCCAGAGGTGATGGAAGCGGCAATCGATGCTGGTGCGAATGTTATAAATGATGTTTATGCTTTAAGAAGGGATG
GTGCTCTGAATGTTGCTGCGCAGTTAGATGTTCCTGTTTGTTTAATGCACATGAAAGGAGAGCCGCGAACTATGCAAGAA
AATCCTTCTTACCCAGAAGGAATAATGAAGGAATTACAGCATTTTTTTAAAGAGCGCATCGATAAATGCCAGAAAGCTGG
GCTGAATAAGAATAAATTAATTCTTGACCCTGGCTTTGGTTTTGGAAAGCGCGTTAAAGATAACCTAAAATTAATTTATC
ATCTGAACGAATTGCGTTCTTTTGGATTGCCAATTCTTTTGGGCGTTTCACGCAAAAGCACAATTGGTGCTGTATTGAAT
AATGAAGTTGAGCAACGTTTGATTGGAAGTATTACGCTAGGAATATATGCTGCTCTTAAAGGCACTGCAATTATCAGGAC
ACATGATGTGGATGAAACGAATCAAGCATTAACTATGATTAATGCAATTTATCAAGCTGCTAAAGAAATCGGTTAA

Upstream 100 bases:

>100_bases
CGGTTAATGATGCTCCTGCAAAGCCTATTAATGGCGAAACAATAGAAAATCCGGCAGAAGGACATTAATTTTATCAGTAG
TTATTTATCGAGAGTACCCT

Downstream 100 bases:

>100_bases
TAGCTCATGAAATGATCAGAAGACAACTGAGATTAGAAAAATTAAATAATAAGGTAGGTAAGGATGAGTCAACGTAAATA
TTTTGGTACGGATGGAATAC

Product: 7,8-dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNSEQFLGWLERKSQPPSSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDSACDQALKLIACGADLIDIGGESTKPGAPPVP
LDVELSRVLPVIKQLRVLADVCISIDTNKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQE
NPSYPEGIMKELQHFFKERIDKCQKAGLNKNKLILDPGFGFGKRVKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLN
NEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIG

Sequences:

>Translated_291_residues
MNSEQFLGWLERKSQPPSSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDSACDQALKLIACGADLIDIGGESTKPGAPPVP
LDVELSRVLPVIKQLRVLADVCISIDTNKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQE
NPSYPEGIMKELQHFFKERIDKCQKAGLNKNKLILDPGFGFGKRVKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLN
NEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIG
>Mature_291_residues
MNSEQFLGWLERKSQPPSSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDSACDQALKLIACGADLIDIGGESTKPGAPPVP
LDVELSRVLPVIKQLRVLADVCISIDTNKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQE
NPSYPEGIMKELQHFFKERIDKCQKAGLNKNKLILDPGFGFGKRVKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLN
NEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=269, Percent_Identity=47.2118959107807, Blast_Score=261, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6324073, Length=339, Percent_Identity=26.5486725663717, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31803; Mature: 31803

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSEQFLGWLERKSQPPSSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDSACDQALKLIAC
CCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHC
GADLIDIGGESTKPGAPPVPLDVELSRVLPVIKQLRVLADVCISIDTNKPEVMEAAIDAG
CCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
ANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFKERI
HHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DKCQKAGLNKNKLILDPGFGFGKRVKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLN
HHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
NEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSEQFLGWLERKSQPPSSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDSACDQALKLIAC
CCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHC
GADLIDIGGESTKPGAPPVPLDVELSRVLPVIKQLRVLADVCISIDTNKPEVMEAAIDAG
CCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
ANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFKERI
HHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DKCQKAGLNKNKLILDPGFGFGKRVKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLN
HHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
NEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]