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The map label for this gene is nuoL

Identifier: 52842976

GI number: 52842976

Start: 3129805

End: 3131778

Strand: Reverse

Name: nuoL

Synonym: lpg2778

Alternate gene names: 52842976

Gene position: 3131778-3129805 (Counterclockwise)

Preceding gene: 52842977

Following gene: 52842975

Centisome position: 92.17

GC content: 40.12

Gene sequence:

>1974_bases
GTGAGTATTCAACAAGTCTGCTTAGTAATCGTTTTGACTCCCCTTGTTGGTTCTGCAATAGCAGGATTTTTTAGAAACCA
GATTGGACGAGTCGGAGCTCATACTGTAACTATTTTAGGCGTAGCTATTTCCTTAGCCTGTTCAATTTTTCTTGCGTGGG
GCCTGTTTTCTGGTTCAATCCCAAACACTAATAGTCTTGTTTACCACTGGGCTAGCGGGGGGGCGTTAATTCCCTACGAA
TTTAATATTGGTTTTTTAATAGACCCTCTAAGCGTTGTGATGCTGGTTATAGTTAATTTTGTTTCTTTGTTAGTCCATGT
CTACAGTATTGGGTACATGGCAGATGATGATGGTTATCAGCGATTTTTTAGTTATATCTCTTTATTTACATTCATGATGC
TCATGTTAGTTAGCGCAAACAACTTTCTGCAATTATTTTTTGGCTGGGAAGGGGTTGGGCTTGTTTCTTATTTATTAATC
GGATTTTGGTATCAAAAGGAATCTGCAATAGAAGGCAGCCTGAAAGCATTTCTTGTAAACCGTGTAGGAGATTTTGGATT
TGTATTAGGAATAGGTTTAATTTTTGCTTATTCTGGAAGCCTTGATTATGAAAAAGTATTTACCAGCGCAAATTATTTAG
CAAGCCAGAACATAGAGTTATTTAGCGGCTACTCCTGGTCCCTGATTACAGTTATTTGCCTGCTGCTTTTTGTTGGCGCC
ATGGGCAAATCAGCACAGGTGCCACTTCACGTTTGGTTACCTGAGTCAATGGAGGGTCCAACCCCTATTTCAGCGCTAAT
CCATGCGGCGACAATGGTGACAGCGGGTGTTTTCATGATTGCTCGCATCTCACCTTTAATTGAATTGTCTACAGCTGCGC
TTAGCACAGTATTAGTAATTGGTGCTACAGGAGCATTGTTTACAGGAATACTGGCTTTGGTTATGAACGATATAAAGCGC
GTGGTAGCATACTCTACTTTATCACAACTAGGCTATATGATGGTGGCAATGGGTGCCTCAGCCTATAGTGCCGGTATGTT
TCATTTATTGACGCATGCTTGCTTTAAAGCGCTATTGTTCCTTGGTGCTGGTTCAGTCATTATTGGCATGCATCATGAAC
AAGATATGCGGAAAATGGGTGGGTTATGGAATAAAATGCCGATTACCTATGTAACCTATGTCATAGGCAGTTTGGCATTG
TGTGCATTTCCTCCTTTTGCTGGTTTTTATTCAAAAGATACCATTATTGAAGCAGCGCAGCTTTCCCAGATACCCGGCAG
CAGTTATGCTTATTTTTGTGTAACAGCAGGCGCTATGGTTACAGCATTATATACTTTCAGATCCTTATTCATGACATTTC
ATGGTAAGCCACGTATGGATGAACATACATTAAGTCATCTTCATGAATCTCCATGGGTAGTATGGTTACCATTAGTATTG
CTCGCTATCCCATCAATAATTTTAGGCTATGTGCTTTACATGCCTATTCTATTTGATACACCAAGCCTCTTAGGCTCATC
AATTTTTGTTTTACCTGAGCATAATGTTTTAGCTGAACTTGCTCATGAAGTAAGTTCGCCATTTGCAAGTGCTGTTCACG
CGATTTATTCTTTGCCATTTTGGATTACAGTACTCGGAGCAGTTATTGCCTGGATTTGTTATATCGCTGTCCCATCTATT
CCTGGTTATTTAGCTAGGTATTTTTCAATTATCTATTCTATTTTACTCAATAAATACGGGTTTGATCGCTTTAACGAGTT
GTTCTTTGTGAAAGGAGCTAGAGGATTAGGCATTGCTTTTTACAAGATTGGTGATCAAAAACTAATTGATGGTGCAGTTG
TCAATGGTAGTGGACGCCTGGTTCGCTGGTTCTCTGGGAAAGGGCGAAAGATACAAAGTGGGTACATCTATCATTATGCG
ACAGTAATGGTGTTTGGATTGCTGGCCTTTTTATGCTGGTTAATCCTGGACTGA

Upstream 100 bases:

>100_bases
GCAGCGGAAGCAGCAATAGGTTTGGCCATAGTCATGTTGCTCTATAGAAATAGAGGCAATATTGACGTTGATAAAATGAA
TCATTTAAAAGGTTAAAATC

Downstream 100 bases:

>100_bases
AGATAAGGTGAAGGTATGCATTATTTGCTCAATTTATTAATTTGGTTACCTATATTGGGTGGCGTTTTTGTTTTGCTGAC
TGGGGATGATAAAAATCCAA

Product: NADH dehydrogenase I, L subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSIPNTNSLVYHWASGGALIPYE
FNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQRFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLI
GFWYQKESAIEGSLKAFLVNRVGDFGFVLGIGLIFAYSGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVIGATGALFTGILALVMNDIKR
VVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLFLGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLAL
CAFPPFAGFYSKDTIIEAAQLSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPFWITVLGAVIAWICYIAVPSI
PGYLARYFSIIYSILLNKYGFDRFNELFFVKGARGLGIAFYKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYA
TVMVFGLLAFLCWLILD

Sequences:

>Translated_657_residues
MSIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSIPNTNSLVYHWASGGALIPYE
FNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQRFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLI
GFWYQKESAIEGSLKAFLVNRVGDFGFVLGIGLIFAYSGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVIGATGALFTGILALVMNDIKR
VVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLFLGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLAL
CAFPPFAGFYSKDTIIEAAQLSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPFWITVLGAVIAWICYIAVPSI
PGYLARYFSIIYSILLNKYGFDRFNELFFVKGARGLGIAFYKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYA
TVMVFGLLAFLCWLILD
>Mature_656_residues
SIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSIPNTNSLVYHWASGGALIPYEF
NIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQRFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLIG
FWYQKESAIEGSLKAFLVNRVGDFGFVLGIGLIFAYSGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGAM
GKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVIGATGALFTGILALVMNDIKRV
VAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLFLGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLALC
AFPPFAGFYSKDTIIEAAQLSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVLL
AIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPFWITVLGAVIAWICYIAVPSIP
GYLARYFSIIYSILLNKYGFDRFNELFFVKGARGLGIAFYKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYAT
VMVFGLLAFLCWLILD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=425, Percent_Identity=39.7647058823529, Blast_Score=299, Evalue=5e-81,
Organism=Escherichia coli, GI1788614, Length=656, Percent_Identity=37.6524390243902, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1788829, Length=351, Percent_Identity=31.9088319088319, Blast_Score=150, Evalue=4e-37,
Organism=Escherichia coli, GI1788827, Length=438, Percent_Identity=29.2237442922374, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=27.9538904899135, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI2367154, Length=444, Percent_Identity=25.2252252252252, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788613, Length=395, Percent_Identity=26.5822784810127, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI145693160, Length=309, Percent_Identity=24.5954692556634, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71959; Mature: 71828

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNTNSLVYHWASGGALIPYEFNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQ
CCCCCEEEEEECCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHH
RFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLIGFWYQKESAIEGSLKAFLVN
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGDFGFVLGIGLIFAYSGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
HCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHCC
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATGALFTGILALVMNDIKRVVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLALCAFPPFAGFYSKDTIIEAAQ
HCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHH
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPF
HHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHH
WITVLGAVIAWICYIAVPSIPGYLARYFSIIYSILLNKYGFDRFNELFFVKGARGLGIAF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEECCCCCEEEE
YKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYATVMVFGLLAFLCWLILD
EEECCCCEECCEEECCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNTNSLVYHWASGGALIPYEFNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQ
CCCCCEEEEEECCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHH
RFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLIGFWYQKESAIEGSLKAFLVN
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGDFGFVLGIGLIFAYSGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
HCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHCC
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATGALFTGILALVMNDIKRVVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLALCAFPPFAGFYSKDTIIEAAQ
HCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHH
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPF
HHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHH
WITVLGAVIAWICYIAVPSIPGYLARYFSIIYSILLNKYGFDRFNELFFVKGARGLGIAF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEECCCCCEEEE
YKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYATVMVFGLLAFLCWLILD
EEECCCCEECCEEECCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]