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The map label for this gene is nuoM

Identifier: 52842975

GI number: 52842975

Start: 3128284

End: 3129789

Strand: Reverse

Name: nuoM

Synonym: lpg2777

Alternate gene names: 52842975

Gene position: 3129789-3128284 (Counterclockwise)

Preceding gene: 52842976

Following gene: 52842974

Centisome position: 92.11

GC content: 37.12

Gene sequence:

>1506_bases
ATGCATTATTTGCTCAATTTATTAATTTGGTTACCTATATTGGGTGGCGTTTTTGTTTTGCTGACTGGGGATGATAAAAA
TCCAAATGTATCGCGTTATTTAACATTATTCACCATACTTCTCTGTTTAGTGCTCTGCATACCTTTAGTTAAAGGATTTG
ATCTGCAATCTTTTGGCATGCAATTTATAGAGGAAATCCCCTGGATGCCGGCACTGGGTATTAATTATACTCTTGGTATT
GATGGGTTATCTTTACTATTAATTGTTTTATCCATTTTTACTAATTTGATAGTGATTTTGGCTACATGGGATAGCATTAG
TAAAAAAGTTTCCCAATATTTATCAGCCTTTTTAATTATGCAAGGCCTTCTGGTCGGTATATTTTCTGCTATGGATGCCA
TAGTATTTTATATTTTCTGGGAAGCAACTTTGATTCCAATGTATCTGATTATAGGTATTTGGGGTTCTGATAACAGAGTT
TATGCAGCAATAAAATTTTTCCTATATACTTTTTTAGGGTCAGTTCTCATGCTGGCCAGTTTCCTGTACATGGGCTACAT
TGCAGGTTCATTTAAGATTGAAACCTTTTATGCTATCAAATTAGGCATGACTGCACAAACATTGATTTTTATTGCATTTT
TCTTAGGTTTTGCAATAAAAATACCGATGTTTCCAGTCCATACCTGGTTGCCAGATGCGCATACTGAAGCTCCCGCTGGT
GGTTCTGTCGTTTTAGCAGCAATTTTGCTAAAACTGGGTGCTTATGGATTTATCCGTTTTTCTTTACCAATAGTCCCGGA
CGCTTGCAGCAAATATGCTCCTCTGATGGTTGCCTTATCTTTGATCGCAGTGGTTTATATAGGACTCATTGCAATTATTC
AGAAGGATATGAAAAAATTGATTGCATATTCTTCAATTTCACATATGGGTTTTGTAACTCTAGGCTGTTTCGCTATATTT
GCAATTGCTCGTCATGGGGGACTAAGCAACGCCGGTTTAATCCTTGAGGGCGCAATTGTCGTTATGATATCGCATGCCTT
TGTCTCAAGTGCAATGTTTGCAGGTGTAGGTTTTATATATGATCGTATGCATACAAGGCAGCTCGCGGATTTTGGCGGAA
TAGTAAATACTATGCCTATATTTGCTTCTTTTTTTATGCTTTTTGCTATGGCGAATGCCGGCTTGCCAGGAACATCCGGA
TTTGTTGGTGAGTTTATGGTGATATTAGGTAGTATAAAGGCTGGTTTTTGGGTTGCATTTTGGGCTGCAACTACATTGAT
TATTGGAGCAGCATATACGCTATGGATGTACAAAAGAGTTATTTTTGGTCCTGTAGCTAATAAAAAGGTTGCTGCCTTAA
AAGATATATCAGGTTTTGAATTAAGTGCTTATGTATTGCTTGCAATAATGGTCATTGCTCTAGGAGTGTATCCCAAACCC
ATGTTAGAGTTTGTGCATCAAACTGTAAGTCATACTTTGGCACTGGCTGATAAATCTAAACTCTAA

Upstream 100 bases:

>100_bases
GATACAAAGTGGGTACATCTATCATTATGCGACAGTAATGGTGTTTGGATTGCTGGCCTTTTTATGCTGGTTAATCCTGG
ACTGAAGATAAGGTGAAGGT

Downstream 100 bases:

>100_bases
CAAAGAACTGCGATAGGCTTACATTGCAATCAAGTTCCTTAGCAAGGTTAAATATGATGACATTACTAGAAAATATCCAT
GTAGCAATACCAGAAATGAT

Product: NADH dehydrogenase I, M subunit

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGMQFIEEIPWMPALGINYTLGI
DGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIMQGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRV
YAAIKFFLYTFLGSVLMLASFLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKLIAYSSISHMGFVTLGCFAIF
AIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIYDRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSG
FVGEFMVILGSIKAGFWVAFWAATTLIIGAAYTLWMYKRVIFGPVANKKVAALKDISGFELSAYVLLAIMVIALGVYPKP
MLEFVHQTVSHTLALADKSKL

Sequences:

>Translated_501_residues
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGMQFIEEIPWMPALGINYTLGI
DGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIMQGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRV
YAAIKFFLYTFLGSVLMLASFLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKLIAYSSISHMGFVTLGCFAIF
AIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIYDRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSG
FVGEFMVILGSIKAGFWVAFWAATTLIIGAAYTLWMYKRVIFGPVANKKVAALKDISGFELSAYVLLAIMVIALGVYPKP
MLEFVHQTVSHTLALADKSKL
>Mature_501_residues
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGMQFIEEIPWMPALGINYTLGI
DGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIMQGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRV
YAAIKFFLYTFLGSVLMLASFLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKLIAYSSISHMGFVTLGCFAIF
AIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIYDRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSG
FVGEFMVILGSIKAGFWVAFWAATTLIIGAAYTLWMYKRVIFGPVANKKVAALKDISGFELSAYVLLAIMVIALGVYPKP
MLEFVHQTVSHTLALADKSKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=349, Percent_Identity=34.6704871060172, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI251831117, Length=337, Percent_Identity=24.3323442136499, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1788613, Length=507, Percent_Identity=35.8974358974359, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1788827, Length=278, Percent_Identity=26.2589928057554, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788831, Length=380, Percent_Identity=26.8421052631579, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI145693160, Length=299, Percent_Identity=27.4247491638796, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788829, Length=411, Percent_Identity=24.8175182481752, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788614, Length=432, Percent_Identity=23.3796296296296, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI2367154, Length=208, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54817; Mature: 54817

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGM
CHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QFIEEIPWMPALGINYTLGIDGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIM
HHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRVYAAIKFFLYTFLGSVLMLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
HHHHHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCC
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKL
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYSSISHMGFVTLGCFAIFAIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSGFVGEFMVILGSIKAGFWVAF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
WAATTLIIGAAYTLWMYKRVIFGPVANKKVAALKDISGFELSAYVLLAIMVIALGVYPKP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHH
MLEFVHQTVSHTLALADKSKL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGM
CHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QFIEEIPWMPALGINYTLGIDGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIM
HHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRVYAAIKFFLYTFLGSVLMLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
HHHHHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCC
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKL
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYSSISHMGFVTLGCFAIFAIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSGFVGEFMVILGSIKAGFWVAF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
WAATTLIIGAAYTLWMYKRVIFGPVANKKVAALKDISGFELSAYVLLAIMVIALGVYPKP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHH
MLEFVHQTVSHTLALADKSKL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]