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The map label for this gene is adhA [H]

Identifier: 52842700

GI number: 52842700

Start: 2809091

End: 2810077

Strand: Direct

Name: adhA [H]

Synonym: lpg2492

Alternate gene names: 52842700

Gene position: 2809091-2810077 (Clockwise)

Preceding gene: 52842698

Following gene: 52842701

Centisome position: 82.67

GC content: 43.26

Gene sequence:

>987_bases
ATGCATGCCATGATCATGGAAAAGCCTGGATGTGAATTGCAATATCAGGAAGTCAATAAACCAAATCCAAATGAAAATGA
ACTTTTAATTAAAGTATCAGCTTGTGGGATTTGTAGAACTGACTTGCATGTTGTCGATGGTGAGTTGAAAAATCCCAAGA
CTCCCCTTATTCCAGGCCACCAAATTGTAGGAACTGTTGAGCAGGTTGGATCCGCTGTTAAGAAATTTGCAATTGGACAG
CGAGTTGGAGTCCCTTGGCTAGGTGGAAGTTGCGGGATCTGTAATTTTTGCACCTCTGGCCGAGAAAATTTGTGTGATCA
AGCCTGCTTTACCGGGTATCAAATAGATGGTGGTTTCGCTGAGTTCTGTGTAGCAAATTACCATTTTTGCTTTCCTATTC
CCGATGGATACCCGGATCATCAGGCAGCACCATTATTTTGTGCTGGTTTAATTGGATATCGTGCCTTGCTAAAGGCTGGT
GACGCAACTCATTTAGGTCTATATGGATTTGGAGCGGCCGCACATATACTGATTCAAGTGGCTTGCCAAAAAGGAATAAA
AATTTATGCATTTACAAGCCCAGGCGATCAGGAAACTCAAAGATTTGCATACCGATTAGGTGCTGTCTGGGCCGGGGATT
CTACGCAATCACCACCTCATCTTCTTGATGCAGCAATCATTTTTGCACCCGTTGGTGCATTAGTGCCTCAGGCTCTTAGC
CATACTGTAAAAGGAGGTACTGTGGTTTGTGCTGGTATACATATGTCGGATATTCCCAGCTTCCCTTATGAAATACTATG
GGGTGAACGCACTGTATGTTCAATTGCCAATCTAACTCGCAAAGATGGAGAAGAGTTCCTGTCTCTAGCCCCTAAAATCC
CAGTTAAGACAAAAGTTCAAACCTATCCCCTTACCGAAGTTAATCGAGCACTGGATGATTTAAGACATGGCAGGTATAGA
GGAGCCGGGGTTATTGTTATGAAATAA

Upstream 100 bases:

>100_bases
AGCATTGATGTCAAATATTGTTACTTTTTGAATGCATTAAGTAAGTATAACCCATCCTACTATAATTGTAAGATAGAGGA
TAAAAACAGGACCAATACCC

Downstream 100 bases:

>100_bases
GGCTATAATTATCAAAAGCTATTACAACAAATTCAAATCATCAAGGAAGTAACTCGCCTCGCTCAAAATTGGTTTAAGCA
ACATTTAGAAAGAATAAAAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MHAMIMEKPGCELQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKTPLIPGHQIVGTVEQVGSAVKKFAIGQ
RVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFAEFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKAG
DATHLGLYGFGAAAHILIQVACQKGIKIYAFTSPGDQETQRFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALS
HTVKGGTVVCAGIHMSDIPSFPYEILWGERTVCSIANLTRKDGEEFLSLAPKIPVKTKVQTYPLTEVNRALDDLRHGRYR
GAGVIVMK

Sequences:

>Translated_328_residues
MHAMIMEKPGCELQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKTPLIPGHQIVGTVEQVGSAVKKFAIGQ
RVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFAEFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKAG
DATHLGLYGFGAAAHILIQVACQKGIKIYAFTSPGDQETQRFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALS
HTVKGGTVVCAGIHMSDIPSFPYEILWGERTVCSIANLTRKDGEEFLSLAPKIPVKTKVQTYPLTEVNRALDDLRHGRYR
GAGVIVMK
>Mature_328_residues
MHAMIMEKPGCELQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKTPLIPGHQIVGTVEQVGSAVKKFAIGQ
RVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFAEFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKAG
DATHLGLYGFGAAAHILIQVACQKGIKIYAFTSPGDQETQRFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALS
HTVKGGTVVCAGIHMSDIPSFPYEILWGERTVCSIANLTRKDGEEFLSLAPKIPVKTKVQTYPLTEVNRALDDLRHGRYR
GAGVIVMK

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=145, Percent_Identity=33.1034482758621, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI71743840, Length=168, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI262073058, Length=168, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI194239674, Length=327, Percent_Identity=24.7706422018349, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI13236495, Length=327, Percent_Identity=24.7706422018349, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI194239676, Length=200, Percent_Identity=28, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501933, Length=100, Percent_Identity=39, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=319, Percent_Identity=32.6018808777429, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082401, Length=321, Percent_Identity=27.1028037383178, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786518, Length=239, Percent_Identity=32.6359832635983, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1787863, Length=223, Percent_Identity=30.0448430493274, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI226510992, Length=163, Percent_Identity=34.3558282208589, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790045, Length=147, Percent_Identity=36.0544217687075, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788073, Length=159, Percent_Identity=31.4465408805031, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082125, Length=187, Percent_Identity=27.807486631016, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788075, Length=143, Percent_Identity=28.6713286713287, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=28.6135693215339, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=26.9005847953216, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=332, Percent_Identity=27.1084337349398, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=128, Percent_Identity=35.15625, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=138, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=28.955223880597, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=202, Percent_Identity=35.1485148514851, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324486, Length=149, Percent_Identity=40.9395973154362, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319621, Length=158, Percent_Identity=36.0759493670886, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323980, Length=149, Percent_Identity=38.255033557047, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319949, Length=327, Percent_Identity=28.7461773700306, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=153, Percent_Identity=36.6013071895425, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=146, Percent_Identity=34.2465753424658, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737895, Length=356, Percent_Identity=24.438202247191, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737897, Length=138, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35403; Mature: 35403

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAMIMEKPGCELQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKTPLIPGH
CCCCEECCCCCCEEHHCCCCCCCCCCEEEEEEECCCEEECCCEEECCCCCCCCCCCCCCH
QIVGTVEQVGSAVKKFAIGQRVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFA
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCHHHHHHHHHHCCEEECCCHH
EFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKAGDATHLGLYGFGAAAHILIQV
HHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECEEHHHHHHHHHHHH
ACQKGIKIYAFTSPGDQETQRFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALS
HHHCCCEEEEEECCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HTVKGGTVVCAGIHMSDIPSFPYEILWGERTVCSIANLTRKDGEEFLSLAPKIPVKTKVQ
HHCCCCEEEEEECCHHCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHCCCCCCCCEEE
TYPLTEVNRALDDLRHGRYRGAGVIVMK
ECCHHHHHHHHHHHHCCCCCCCEEEEEC
>Mature Secondary Structure
MHAMIMEKPGCELQYQEVNKPNPNENELLIKVSACGICRTDLHVVDGELKNPKTPLIPGH
CCCCEECCCCCCEEHHCCCCCCCCCCEEEEEEECCCEEECCCEEECCCCCCCCCCCCCCH
QIVGTVEQVGSAVKKFAIGQRVGVPWLGGSCGICNFCTSGRENLCDQACFTGYQIDGGFA
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHCCCHHHHHHHHHHCCEEECCCHH
EFCVANYHFCFPIPDGYPDHQAAPLFCAGLIGYRALLKAGDATHLGLYGFGAAAHILIQV
HHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECEEHHHHHHHHHHHH
ACQKGIKIYAFTSPGDQETQRFAYRLGAVWAGDSTQSPPHLLDAAIIFAPVGALVPQALS
HHHCCCEEEEEECCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HTVKGGTVVCAGIHMSDIPSFPYEILWGERTVCSIANLTRKDGEEFLSLAPKIPVKTKVQ
HHCCCCEEEEEECCHHCCCCCCCEEEECCCHHHHHHHHHHHCHHHHHHHCCCCCCCCEEE
TYPLTEVNRALDDLRHGRYRGAGVIVMK
ECCHHHHHHHHHHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]