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The map label for this gene is aacA4 [H]

Identifier: 52842607

GI number: 52842607

Start: 2708876

End: 2709448

Strand: Reverse

Name: aacA4 [H]

Synonym: lpg2398

Alternate gene names: 52842607

Gene position: 2709448-2708876 (Counterclockwise)

Preceding gene: 52842608

Following gene: 52842606

Centisome position: 79.74

GC content: 38.74

Gene sequence:

>573_bases
ATGGCATTGATAAGGGATTCAAAGAGCCAAGTCATGAGTGTTTTTAAATTTCAACCTCTGGGCATCAAGGATTTAAATCA
ACTGTATCAATGGTTTCAGGAGCCAATTATTAATCATTGGTATGCGAGAGACAAAAGTTGGTCACTGGATGAAATCACAG
AAAAATATGAACCAAGAATTGCAGGTATGGAGCATGTTCCAAGTTTCATTGTATATAAAGATGACTTGCCTTTCGGGTTC
GTCCAGTTTTACATACTCACAGACTCTTTACCCGATGGAATTGATGGTTATGAGAGTTTTCTCTTTGAAAAATATAATCC
CAGGGATTTAGCTGGAATCGATTTGTTTATTGCTGAAAGCGAGGGACGAGGTAGAGGATTAGGGGTGGAACTCATTAATC
GCTTTATTGATAAGTTTCTTACCCGTTTCAAAGCTGTTGTTGTTGACCCCGATGTTAACAATCAACAAGCCATTCGTTGC
TACGAAAAAGCGGGCTTTCAGCAAACAGGTTTCAGCCAGGATCCCAATCATCTCATCATGATAAAATCCTTGTCATTGAT
TACAGGGAATTAA

Upstream 100 bases:

>100_bases
AGAATACCCACTCAGTTTTTGCCTACAGTATAGTGAATCATGATTATCCGCAAACCTGACATATGGAAATCAATTTGGCA
TGCCTCAGATGTGAGTCGTC

Downstream 100 bases:

>100_bases
TGATGAGCCTATTGAAAATAGAACGTTGTTTTGGCAATTTACCAAGGGTTTTAAATGATAAAATCATTTCGTGTCACAGT
TTTTTTATTTCTTGTAAGTG

Product: aminoglycoside 6'-N-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRIAGMEHVPSFIVYKDDLPFGF
VQFYILTDSLPDGIDGYESFLFEKYNPRDLAGIDLFIAESEGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRC
YEKAGFQQTGFSQDPNHLIMIKSLSLITGN

Sequences:

>Translated_190_residues
MALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRIAGMEHVPSFIVYKDDLPFGF
VQFYILTDSLPDGIDGYESFLFEKYNPRDLAGIDLFIAESEGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRC
YEKAGFQQTGFSQDPNHLIMIKSLSLITGN
>Mature_189_residues
ALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRIAGMEHVPSFIVYKDDLPFGFV
QFYILTDSLPDGIDGYESFLFEKYNPRDLAGIDLFIAESEGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRCY
EKAGFQQTGFSQDPNHLIMIKSLSLITGN

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: COG1670

COG function: function code J; Acetyltransferases, including N-acetylases of ribosomal proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 21987; Mature: 21856

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRI
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
AGMEHVPSFIVYKDDLPFGFVQFYILTDSLPDGIDGYESFLFEKYNPRDLAGIDLFIAES
CCHHHCCCEEEEECCCCHHHEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECC
EGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRCYEKAGFQQTGFSQDPNHLIM
CCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEE
IKSLSLITGN
EEEEEEEECC
>Mature Secondary Structure 
ALIRDSKSQVMSVFKFQPLGIKDLNQLYQWFQEPIINHWYARDKSWSLDEITEKYEPRI
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
AGMEHVPSFIVYKDDLPFGFVQFYILTDSLPDGIDGYESFLFEKYNPRDLAGIDLFIAES
CCHHHCCCEEEEECCCCHHHEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCEEEEEECC
EGRGRGLGVELINRFIDKFLTRFKAVVVDPDVNNQQAIRCYEKAGFQQTGFSQDPNHLIM
CCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEE
IKSLSLITGN
EEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]