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The map label for this gene is hpd

Identifier: 52842491

GI number: 52842491

Start: 2580649

End: 2581734

Strand: Direct

Name: hpd

Synonym: lpg2278

Alternate gene names: 52842491

Gene position: 2580649-2581734 (Clockwise)

Preceding gene: 52842490

Following gene: 52842492

Centisome position: 75.95

GC content: 40.7

Gene sequence:

>1086_bases
CTGCATTGCTATGTAAATAAGTACAAGGAGAATCTGATAATGCAAAATAACAACCCCTGCGGATTAGATGGCTTTGCCTT
TTTAGAGTTTTCAGGCCCTGATAGGAATAAATTACATCAGCAATTTTCTGAGATGGGGTTTCAGGCTGTTGCCCACCATA
AAAATCAAGACATTACTCTTTTCAAACAAGGGGAAATACAATTTATAGTGAATGCGGCCTCCCATTGTCAGGCAGAAGCG
CATGCTTCAACTCATGGTCCAGGCGCTTGTGCAATGGGCTTTAAAGTAAAAGATGCCAAAGCCGCTTTTCAACACGCTAT
CGCGCATGGCGGTATAGCATTTCAGGATGCACCTCATGCCAATCACGGCTTGCCAGCCATCCAGGCTATTGGTGGTAGTG
TTATTTATTTTGTCGATGAAGAACACCAACCCTTCTCTCATGAATGGAATATTACCTCACCAGAACCCGTAGTTGGAAAT
GGTCTGACAGCAATCGACCATCTCACCCATAACGTTTATCGCGGTAATATGGATAAATGGGCCAGTTTCTATGCTTCCAT
TTTTAACTTCCAGGAAATTCGTTTTTTCAATATCAAAGGAAAAATGACAGGTTTGGTTAGTCGAGCATTAGGTAGCCCTT
GTGGCAAAATCAAAATTCCTTTAAACGAATCCAAAGATGATTTATCACAAATTGAAGAGTTTCTTCATGAATATCATGGC
GAGGGCATTCAACACATCGCTCTCAATACCAATGATATTTATAAAACAGTCAACGGCTTAAGAAAACAAGGGGTCAAATT
CCTGGATGTGCCAGATACTTACTATGAGATGATTAATGACCGCCTCCCATGGCACAAGGAGCCACTGAATCAACTCCATG
CTGAGAAAATTTTAATTGATGGAGAAGCAGATCCCAAAGACGGCTTGTTACTGCAAATATTTACTGAAAACATATTTGGA
CCAGTCTTTTTTGAAATTATTCAACGCAAAGGCAATCAGGGGTTTGGTGAAGGGAATTTCCAGGCTCTATTCGAAGCTAT
TGAAAGAGATCAAGTTCGACGTGGTACTTTAAAAGAATTAAGCTAG

Upstream 100 bases:

>100_bases
TAAAAACGATTCAAGGGTCTTTGTCAGTTTGTTAGCTATAGCTGATGGGATGTTTCTGGTGCAACCCATTTAATCTTTAA
AATCCCCGGCAAGCAATACA

Downstream 100 bases:

>100_bases
ACAAACAGTTGAAATGTAATGATGCTGTTTTTCAGGCATAAGCCAGGAGATCTATATGAAACTCGCCAGTTTGAAATCAA
CTCGTTCCCGGGATGGAGAG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase; Legiolysin [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MHCYVNKYKENLIMQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEA
HASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGN
GLTAIDHLTHNVYRGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHG
EGIQHIALNTNDIYKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFG
PVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELS

Sequences:

>Translated_361_residues
MHCYVNKYKENLIMQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEA
HASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGN
GLTAIDHLTHNVYRGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHG
EGIQHIALNTNDIYKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFG
PVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELS
>Mature_361_residues
MHCYVNKYKENLIMQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEA
HASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGN
GLTAIDHLTHNVYRGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHG
EGIQHIALNTNDIYKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFG
PVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELS

Specific function: Catalyzes the transformation of p-hydroxyphenylpyruvate into HGA. Has hemolytic and brown pigment production activity [H]

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=352, Percent_Identity=29.2613636363636, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI285002264, Length=350, Percent_Identity=29.1428571428571, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI14249394, Length=346, Percent_Identity=26.3005780346821, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=346, Percent_Identity=30.635838150289, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=207, Percent_Identity=34.2995169082126, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667510, Length=325, Percent_Identity=33.2307692307692, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=34.1137123745819, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40560; Mature: 40560

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCYVNKYKENLIMQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITL
CCCCHHHHHCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
FKQGEIQFIVNAASHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHA
EECCCEEEEEECHHHHHHHHCCCCCCCCEEEECEEECHHHHHHHHHHHHCCEEECCCCCC
NHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVYRGNMDKW
CCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHH
ASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHG
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCC
EGIQHIALNTNDIYKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILID
CCEEEEEECCHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHEEEEC
GEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKEL
CCCCCCCCEEEEEEHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHC
S
C
>Mature Secondary Structure
MHCYVNKYKENLIMQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITL
CCCCHHHHHCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEE
FKQGEIQFIVNAASHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHA
EECCCEEEEEECHHHHHHHHCCCCCCCCEEEECEEECHHHHHHHHHHHHCCEEECCCCCC
NHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVYRGNMDKW
CCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHH
ASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHG
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCC
EGIQHIALNTNDIYKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILID
CCEEEEEECCHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHEEEEC
GEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKEL
CCCCCCCCEEEEEEHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA