Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 52842490

GI number: 52842490

Start: 2579965

End: 2580621

Strand: Direct

Name: mdmC [H]

Synonym: lpg2277

Alternate gene names: 52842490

Gene position: 2579965-2580621 (Clockwise)

Preceding gene: 52842489

Following gene: 52842491

Centisome position: 75.93

GC content: 38.2

Gene sequence:

>657_bases
ATGAAACATTTATCCCTTACTCCTGAGTTGTACAAATACCTGCTTGATATTTCCTTGCGTGAACATCCTGCTCTTGCGGC
ATTACGCAAAGAAACATCCACTATGGAACTCGCCAATATGCAGGTAGCTCCAGAGCAAGCCCAATTTATGCAGATGCTGA
TACGTTTGACTCGTGCAAAGAAGGTATTGGAACTTGGGACATTCACAGGTTATAGTGCCTTGGCCATGTCCCTTGCTTTG
CCTGATGATGGGCAAGTTATCACCTGTGATATTAATGAGGGATGGACAAAACATGCTCATCCTTATTGGCGTGAAGCCAA
ACAGGAACATAAAATTAAATTACGCCTTGGACCTGCTCTTGACACTTTACACTCATTACTTAATGAAGGTGGAGAGCATC
AATTTGATTTCATTTTTATTGATGCTGACAAAACTAATTATCTGAATTACTATGAACTGGCTTTAAAATTAGTTACACCT
AAAGGATTAATTGCCATAGATAATATTTTTTGGGATGGAAAAGTAATTGATCCGAATGATACGAGTGGACAAACCAGAGA
AATTAAAAAATTAAATCAAGTGATTAAAAACGATTCAAGGGTCTTTGTCAGTTTGTTAGCTATAGCTGATGGGATGTTTC
TGGTGCAACCCATTTAA

Upstream 100 bases:

>100_bases
TGACTGAAATTTTTACTCGCTCTGCTAAAGATAATTTACCTACTAGCGAGATTGCTGATACTTTGGCTAAGGAAAAATTG
GCTTAATTTGGATACCGTTT

Downstream 100 bases:

>100_bases
TCTTTAAAATCCCCGGCAAGCAATACACTGCATTGCTATGTAAATAAGTACAAGGAGAATCTGATAATGCAAAATAACAA
CCCCTGCGGATTAGATGGCT

Product: O-methyltransferase, SAM-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKHLSLTPELYKYLLDISLREHPALAALRKETSTMELANMQVAPEQAQFMQMLIRLTRAKKVLELGTFTGYSALAMSLAL
PDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPALDTLHSLLNEGGEHQFDFIFIDADKTNYLNYYELALKLVTP
KGLIAIDNIFWDGKVIDPNDTSGQTREIKKLNQVIKNDSRVFVSLLAIADGMFLVQPI

Sequences:

>Translated_218_residues
MKHLSLTPELYKYLLDISLREHPALAALRKETSTMELANMQVAPEQAQFMQMLIRLTRAKKVLELGTFTGYSALAMSLAL
PDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPALDTLHSLLNEGGEHQFDFIFIDADKTNYLNYYELALKLVTP
KGLIAIDNIFWDGKVIDPNDTSGQTREIKKLNQVIKNDSRVFVSLLAIADGMFLVQPI
>Mature_218_residues
MKHLSLTPELYKYLLDISLREHPALAALRKETSTMELANMQVAPEQAQFMQMLIRLTRAKKVLELGTFTGYSALAMSLAL
PDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPALDTLHSLLNEGGEHQFDFIFIDADKTNYLNYYELALKLVTP
KGLIAIDNIFWDGKVIDPNDTSGQTREIKKLNQVIKNDSRVFVSLLAIADGMFLVQPI

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=213, Percent_Identity=46.4788732394366, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17565612, Length=207, Percent_Identity=40.5797101449275, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI72001127, Length=195, Percent_Identity=40.5128205128205, Blast_Score=133, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI72001028, Length=208, Percent_Identity=38.9423076923077, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25148771, Length=208, Percent_Identity=37.5, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71991493, Length=181, Percent_Identity=30.3867403314917, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24753; Mature: 24753

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLSLTPELYKYLLDISLREHPALAALRKETSTMELANMQVAPEQAQFMQMLIRLTRAK
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCEECCHHHHHHHHHHHHHHHH
KVLELGTFTGYSALAMSLALPDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPAL
HHHHHHCCCCHHHHHEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECHHH
DTLHSLLNEGGEHQFDFIFIDADKTNYLNYYELALKLVTPKGLIAIDNIFWDGKVIDPND
HHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHEEEEEECCCCEEEEEEEEECCEEECCCC
TSGQTREIKKLNQVIKNDSRVFVSLLAIADGMFLVQPI
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MKHLSLTPELYKYLLDISLREHPALAALRKETSTMELANMQVAPEQAQFMQMLIRLTRAK
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCEECCHHHHHHHHHHHHHHHH
KVLELGTFTGYSALAMSLALPDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPAL
HHHHHHCCCCHHHHHEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECHHH
DTLHSLLNEGGEHQFDFIFIDADKTNYLNYYELALKLVTPKGLIAIDNIFWDGKVIDPND
HHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHEEEEEECCCCEEEEEEEEECCEEECCCC
TSGQTREIKKLNQVIKNDSRVFVSLLAIADGMFLVQPI
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]