Click here to switch to the map view.

The map label for this gene is dctA

Identifier: 52842458

GI number: 52842458

Start: 2545546

End: 2546838

Strand: Reverse

Name: dctA

Synonym: lpg2245

Alternate gene names: 52842458

Gene position: 2546838-2545546 (Counterclockwise)

Preceding gene: 52842459

Following gene: 52842451

Centisome position: 74.96

GC content: 38.9

Gene sequence:

>1293_bases
ATGAATTTTCTTAAAAAATTATATGTACAAGTTCTTCTGGGTGTTTTCATTGGTATTTTGCTTGGATATTTTTTGCCTGA
TGTAGGGGTTCAATTAAAAGCTATAGCCGATGTTTTTATCAAAATCATTAAGATGCTAATTTCTCCTATTATATTTCTCA
CCCTGGTCTCCGGAATCGCAGCAATGAATGATATGAGGCAAGTTGGGCGCTTGGCAGGTGGGGCATTGCTTTTTTTTACG
TTCATCACAACTCTGGCATTGCTAATAGGTCTTCTGGCGACAGATTATTTTAAGCCTGGTGTTGGTTTAAATGTGAATCC
CAATTCTCTGGATGCCAAGGAAGCGAGTTCATACCTTGAGGGGGCACATAAGGTAACCAATGTGACTGATCTGCTAATTA
ATATTATCCCGAGAACTTTTATTAGCGCTTTTGTCGATGGTGAGCTGCTGCAAGTTATTTTTATTTCGATATTGTTTGCT
ATAGGTCTGATTCTTACAGGCAATATGGGCAAATCTTTGGTTAATGGGATGCAAATCCTGTCTAATGTCTTTTTTAAAAT
CATTCATCTTGTAATGTATATGGCGCCTATAGCTGCCTTTGCTGCTATGGCGTTCAGCGTTGGGAAATTTGGAGTTGGCC
CTTTGTTTAATTTAATTGGATTATTGGCTTGTTATTATCTGACCTCCATTTTCTTTATCTTGATTATCTTGGGAAGTCTT
TTGCAATGGTACTGCAAAATTAATATCTGGCATCTGTTACGATATTTAAAGGATGAGCTTTTAATCGTATGGAGTACTGC
TTCCTCCGAAACCGTACTGCCAAGTTTGATGCAGAAACTGGAGCGATTGGGGTGTGAGCAATCTGTAGTCGGTTTGATCT
TGCCATTAGGATATTCTTTTAATTTGGCAGGAACTGCAATCTATTTAACAATGGCAGCTATGTTTATTGCACAGGCTACC
AATACTGATTTAACTGTTTGGCAGGAACTGTCGCTTCTGGGAGTTATGATCATTAGTTCCAAGGGTGCCGCTGGGGTGTC
CGGAAGCGGATTTATTGTGTTGGCAAGCTCATTAGCTACGATAGGACATATTCCTGCTGCAGGTGTCGTTCTTGTTTTGG
GTATCGATAAATTCATGAATGAAGCCAGGTCAATTATTAATATGATGGCTAATGCAATCGCCACGATTATTATTTCCAGG
TGGCAACAATCTTTGGATTACCAGAAAACTCAATTTGAATTGCAAGAAAAAGGACAAGCAGAAACCAAAAGTGTTTATGC
TAGTGAGATGTAA

Upstream 100 bases:

>100_bases
AACTATTCATGTAATAATGATTTGTCTAGGGAAAGAATTTTTAGTGCTTCATGCTTTGCTTTTGAATAGTTGTTTATAGT
AAACGACCTGGAGAATAAAA

Downstream 100 bases:

>100_bases
AATTTCTACAGGACTCACGAAAAACCCCAATCTCATCGTGAAAAATGTTTTTAATTCGGTCATTTAGTTTATCTAAGCTC
CCTCATTAAAAACATTTTTT

Product: C4-dicarboxylate transport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAIADVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLIGLLATDYFKPGVGLNVNPNSLDAKEASSYLEGAHKVTNVTDLLINIIPRTFISAFVDGELLQVIFISILFA
IGLILTGNMGKSLVNGMQILSNVFFKIIHLVMYMAPIAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTQFELQEKGQAETKSVYASEM

Sequences:

>Translated_430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAIADVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLIGLLATDYFKPGVGLNVNPNSLDAKEASSYLEGAHKVTNVTDLLINIIPRTFISAFVDGELLQVIFISILFA
IGLILTGNMGKSLVNGMQILSNVFFKIIHLVMYMAPIAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTQFELQEKGQAETKSVYASEM
>Mature_430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAIADVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLIGLLATDYFKPGVGLNVNPNSLDAKEASSYLEGAHKVTNVTDLLINIIPRTFISAFVDGELLQVIFISILFA
IGLILTGNMGKSLVNGMQILSNVFFKIIHLVMYMAPIAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTQFELQEKGQAETKSVYASEM

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=419, Percent_Identity=24.582338902148, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI169790839, Length=452, Percent_Identity=23.8938053097345, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI4827012, Length=449, Percent_Identity=22.4944320712695, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI66773030, Length=397, Percent_Identity=22.1662468513854, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI40254478, Length=491, Percent_Identity=21.5885947046843, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI5032093, Length=398, Percent_Identity=24.3718592964824, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194239697, Length=292, Percent_Identity=27.0547945205479, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=24.1635687732342, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI223468566, Length=269, Percent_Identity=24.1635687732342, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI301601644, Length=158, Percent_Identity=32.2784810126582, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI262359914, Length=377, Percent_Identity=24.6684350132626, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=47.5961538461538, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1790514, Length=422, Percent_Identity=35.5450236966825, Blast_Score=283, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17537407, Length=430, Percent_Identity=23.2558139534884, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983106, Length=468, Percent_Identity=25.6410256410256, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983099, Length=468, Percent_Identity=25.6410256410256, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=466, Percent_Identity=24.8927038626609, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=22.5321888412017, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=22.8571428571429, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=408, Percent_Identity=21.8137254901961, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24583025, Length=444, Percent_Identity=22.2972972972973, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137668, Length=444, Percent_Identity=22.2972972972973, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583023, Length=444, Percent_Identity=22.2972972972973, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46785; Mature: 46785

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCC
>Mature Secondary Structure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HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA