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The map label for this gene is merA1

Identifier: 52842315

GI number: 52842315

Start: 2348647

End: 2350782

Strand: Reverse

Name: merA1

Synonym: lpg2101

Alternate gene names: 52842315

Gene position: 2350782-2348647 (Counterclockwise)

Preceding gene: 52842316

Following gene: 52842314

Centisome position: 69.19

GC content: 38.95

Gene sequence:

>2136_bases
ATGAAAATTAGTGCAATAAAAACTTGGCTGCCCTTATTAATTATAATAGTTTTATTAGGTCTTTTTTTGGGTTTAGGCTT
AAATAAATACGTAAGTTTTGCCAGTTTACGAGACAATCATGAATGGCTTATAGCCATAACAAAATCACATTTTTATCTGG
TCTCTTTCGTTTTTATAATAATTTATACAGTGGCTGTAGCACTCTCTATCCCAGGTGCTATCTTTTTGACTTTAATAGGC
GGCTTCTTATTTGGAATACTTTGGGGAACTTTTTTGGTGGTTCTAAGTGCCACTTTAGGTGCAACGATTCTTTTTTTTGC
AGTCCAATCGTCCTTAGGCGAAGTGTTTTCCAAGCGTGCTTCAGGTTGGGTTAAGCGGATGCGTTCTGGGTTTAAAGACA
ATGCATTTTCTTATTTGCTCACCTTGCGACTTATCCCATTATTTCCTTTCTGGGTGATTAATATCGTTTCTGCCGTATTG
GGTGTGAGCGCTTCTACTTTTATCATAGCCACTTTTATAGGAATTATTCCTGGCTCTATTGTCTATGTGTCTGTTGGTAA
TGGATTGGGCGAACTATTTGCAGCAAGCCTTCAGCCTAATCTGGGGATTATTTTTGAACCCAAATTTATTCTACCTTTAT
TAGGATTAGCCGCTCTTTCTTTGATTCCTGTTTTTTACAAAAAAAAGGGTAAACAGGGTACTGAAAAAATGAAAGATAAA
GATTTATTTTGTGATTTGGCCATTATTGGCGGGGGTTCTGCAGGCTTAAGTATCGCTGCAGGTTGCTCTCAATTGGGATT
ACAAGTGGTATTGGTTGAACCAAACAAAATGGGAGGTGATTGTTTAAATTACGGTTGTATCCCTTCTAAAACGCTATTGA
ACACTGCCAAAATCTTTTATCAAACCAAACATTCGACTGTTTTAGGTATTCAGGCAAAATCGGTGAAAATTGATTTTTTG
CAAGTGATGCAGCAGGTGCATAATGTGATAGCGTGTATTGCAAAAAATGATTCGGTGGAACGTTTTACCTCTCTAGGTGT
TCAGGTTATTCAAGAAGCAGGGCATTTTATAGGGCCAAAACAGTTTAAATTAAAAAGGAAAATTATTCGGGCCAAACATT
TTGTGATTGCTACAGGCTCATCTCCAGCCATCCCTCCTATCCAGAACTTAAACAAGGTCTCTTATTTAACTAATGAAACC
ATCTTTAACCTAAAAGTACAACCTGAGCATTTGATTGTTATCGGCGGAGGTCCTATAGGCTGTGAATTAGCTCAGGCTTT
CGCAATGCTTGGGTCTAAAGTCACTATTTTAGAAGCCTTTACTATTCTTCCTAAGGATGATGCCGATTGCGTGGCTATTA
TTCGAAGTCAACTTGAGTCGATGCAGATAGCACTTTATGAGCAAATTAAAATTAACAAAATAGAAGAGAGTGCTGATAAG
ACCATTAGTGTTCATTTGGAAAACCAGGACAACCCAATTACTATCACAGGCTCGCATTTGTTGGTATCAACAGGTCGTGT
GGCTAATGTGGACGGGCTCGGTTTGGAAAAAGCAGGCGTTCAATACACCACCAGAGGGATAAACACGAATGCCAGACTTC
AAACCACTAATAAAAAAATCTATGCCATAGGCGATGTGACAGGGCCTTATCAATTTACGCACATGGCTAGTTATCAAGCG
GGTATTGCATTGAGAAATATTGCTTTTAAATGGCCTGCAAAAGTAGATTACAAAGCGGTGCCTTGGGTGACTTATACTGA
GCCCGAATTAGCCCACGTGGGCCTATTGGCGAGTGAGGCCTTAAAAGATCCTACATTAAAAATCACAGAATTTGCCTTCG
CCGAGGTGGACAGAGCCCAAGCGGAAAATAAGGTAAATGGCAAAATAAAAATCATAACCGGTAAAAAAGCTAAAATTTTG
GGTGTGAGCATAGTGGGCGCTCATGCGGGTGAATTAATTTTACCTTGGGTTATAGCCGTTAAAGAACGGAAAAGTTTGCG
AACTTTTACCGATGCGATTGCAGCGTACCCCACTTTTAGTGAAATTAGTAAGCGAGTTGCGGGAGAGTATTATAAGCCGT
TTATATTTTCTTCTAAAATTCGAACTTTCGTTCGTTGGCTAAATAAATTAGGATAA

Upstream 100 bases:

>100_bases
CTATTGGCAAATAAAAAAGGATTTTCATTTTAGTCGAAAGTCAAAAACTTCTGATAAGAAAGTAAGAACGTTATGTGAAT
AATGAAAAGGGCATCATCTT

Downstream 100 bases:

>100_bases
ATCTATGATAGAACAACACCTTAGGCCACTGTATCAACGCCTTTGTGTCAATCCAATTACTCCTGTGTTGATAGAGCGAG
TGACCCCAAATCAAGTCACC

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MKISAIKTWLPLLIIIVLLGLFLGLGLNKYVSFASLRDNHEWLIAITKSHFYLVSFVFIIIYTVAVALSIPGAIFLTLIG
GFLFGILWGTFLVVLSATLGATILFFAVQSSLGEVFSKRASGWVKRMRSGFKDNAFSYLLTLRLIPLFPFWVINIVSAVL
GVSASTFIIATFIGIIPGSIVYVSVGNGLGELFAASLQPNLGIIFEPKFILPLLGLAALSLIPVFYKKKGKQGTEKMKDK
DLFCDLAIIGGGSAGLSIAAGCSQLGLQVVLVEPNKMGGDCLNYGCIPSKTLLNTAKIFYQTKHSTVLGIQAKSVKIDFL
QVMQQVHNVIACIAKNDSVERFTSLGVQVIQEAGHFIGPKQFKLKRKIIRAKHFVIATGSSPAIPPIQNLNKVSYLTNET
IFNLKVQPEHLIVIGGGPIGCELAQAFAMLGSKVTILEAFTILPKDDADCVAIIRSQLESMQIALYEQIKINKIEESADK
TISVHLENQDNPITITGSHLLVSTGRVANVDGLGLEKAGVQYTTRGINTNARLQTTNKKIYAIGDVTGPYQFTHMASYQA
GIALRNIAFKWPAKVDYKAVPWVTYTEPELAHVGLLASEALKDPTLKITEFAFAEVDRAQAENKVNGKIKIITGKKAKIL
GVSIVGAHAGELILPWVIAVKERKSLRTFTDAIAAYPTFSEISKRVAGEYYKPFIFSSKIRTFVRWLNKLG

Sequences:

>Translated_711_residues
MKISAIKTWLPLLIIIVLLGLFLGLGLNKYVSFASLRDNHEWLIAITKSHFYLVSFVFIIIYTVAVALSIPGAIFLTLIG
GFLFGILWGTFLVVLSATLGATILFFAVQSSLGEVFSKRASGWVKRMRSGFKDNAFSYLLTLRLIPLFPFWVINIVSAVL
GVSASTFIIATFIGIIPGSIVYVSVGNGLGELFAASLQPNLGIIFEPKFILPLLGLAALSLIPVFYKKKGKQGTEKMKDK
DLFCDLAIIGGGSAGLSIAAGCSQLGLQVVLVEPNKMGGDCLNYGCIPSKTLLNTAKIFYQTKHSTVLGIQAKSVKIDFL
QVMQQVHNVIACIAKNDSVERFTSLGVQVIQEAGHFIGPKQFKLKRKIIRAKHFVIATGSSPAIPPIQNLNKVSYLTNET
IFNLKVQPEHLIVIGGGPIGCELAQAFAMLGSKVTILEAFTILPKDDADCVAIIRSQLESMQIALYEQIKINKIEESADK
TISVHLENQDNPITITGSHLLVSTGRVANVDGLGLEKAGVQYTTRGINTNARLQTTNKKIYAIGDVTGPYQFTHMASYQA
GIALRNIAFKWPAKVDYKAVPWVTYTEPELAHVGLLASEALKDPTLKITEFAFAEVDRAQAENKVNGKIKIITGKKAKIL
GVSIVGAHAGELILPWVIAVKERKSLRTFTDAIAAYPTFSEISKRVAGEYYKPFIFSSKIRTFVRWLNKLG
>Mature_711_residues
MKISAIKTWLPLLIIIVLLGLFLGLGLNKYVSFASLRDNHEWLIAITKSHFYLVSFVFIIIYTVAVALSIPGAIFLTLIG
GFLFGILWGTFLVVLSATLGATILFFAVQSSLGEVFSKRASGWVKRMRSGFKDNAFSYLLTLRLIPLFPFWVINIVSAVL
GVSASTFIIATFIGIIPGSIVYVSVGNGLGELFAASLQPNLGIIFEPKFILPLLGLAALSLIPVFYKKKGKQGTEKMKDK
DLFCDLAIIGGGSAGLSIAAGCSQLGLQVVLVEPNKMGGDCLNYGCIPSKTLLNTAKIFYQTKHSTVLGIQAKSVKIDFL
QVMQQVHNVIACIAKNDSVERFTSLGVQVIQEAGHFIGPKQFKLKRKIIRAKHFVIATGSSPAIPPIQNLNKVSYLTNET
IFNLKVQPEHLIVIGGGPIGCELAQAFAMLGSKVTILEAFTILPKDDADCVAIIRSQLESMQIALYEQIKINKIEESADK
TISVHLENQDNPITITGSHLLVSTGRVANVDGLGLEKAGVQYTTRGINTNARLQTTNKKIYAIGDVTGPYQFTHMASYQA
GIALRNIAFKWPAKVDYKAVPWVTYTEPELAHVGLLASEALKDPTLKITEFAFAEVDRAQAENKVNGKIKIITGKKAKIL
GVSIVGAHAGELILPWVIAVKERKSLRTFTDAIAAYPTFSEISKRVAGEYYKPFIFSSKIRTFVRWLNKLG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=489, Percent_Identity=30.2658486707566, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=28.2937365010799, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI33519430, Length=428, Percent_Identity=25.7009345794392, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI33519428, Length=428, Percent_Identity=25.7009345794392, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI33519426, Length=428, Percent_Identity=25.7009345794392, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI148277065, Length=428, Percent_Identity=26.1682242990654, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI148277071, Length=428, Percent_Identity=26.1682242990654, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI22035672, Length=469, Percent_Identity=24.9466950959488, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI291045266, Length=447, Percent_Identity=24.6085011185682, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI66392190, Length=193, Percent_Identity=31.0880829015544, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI291045268, Length=440, Percent_Identity=22.0454545454545, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=32.1507760532151, Blast_Score=182, Evalue=8e-47,
Organism=Escherichia coli, GI87081717, Length=447, Percent_Identity=29.3064876957494, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=25.9023354564756, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789915, Length=442, Percent_Identity=27.6018099547511, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=31.0195227765727, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=26.25, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17532687, Length=178, Percent_Identity=33.1460674157303, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=25.2609603340292, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=23.2662192393736, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=23.2662192393736, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321091, Length=487, Percent_Identity=29.9794661190965, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=25.8620689655172, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325240, Length=489, Percent_Identity=26.7893660531697, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358499, Length=482, Percent_Identity=32.5726141078838, Blast_Score=188, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=26.7223382045929, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640551, Length=518, Percent_Identity=26.6409266409266, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640549, Length=480, Percent_Identity=26.6666666666667, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=23.8993710691824, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859941, Length=193, Percent_Identity=29.0155440414508, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 77560; Mature: 77560

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISAIKTWLPLLIIIVLLGLFLGLGLNKYVSFASLRDNHEWLIAITKSHFYLVSFVFII
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHH
IYTVAVALSIPGAIFLTLIGGFLFGILWGTFLVVLSATLGATILFFAVQSSLGEVFSKRA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGWVKRMRSGFKDNAFSYLLTLRLIPLFPFWVINIVSAVLGVSASTFIIATFIGIIPGSI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCE
VYVSVGNGLGELFAASLQPNLGIIFEPKFILPLLGLAALSLIPVFYKKKGKQGTEKMKDK
EEEEECCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
DLFCDLAIIGGGSAGLSIAAGCSQLGLQVVLVEPNKMGGDCLNYGCIPSKTLLNTAKIFY
CCEEEEEEEECCCCCCHHHCCHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHE
QTKHSTVLGIQAKSVKIDFLQVMQQVHNVIACIAKNDSVERFTSLGVQVIQEAGHFIGPK
EECCCEEEEEEECCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCH
QFKLKRKIIRAKHFVIATGSSPAIPPIQNLNKVSYLTNETIFNLKVQPEHLIVIGGGPIG
HHHHHHHHHHHCEEEEECCCCCCCCCHHCCCHHHEECCCEEEEEEECCCEEEEECCCCCH
CELAQAFAMLGSKVTILEAFTILPKDDADCVAIIRSQLESMQIALYEQIKINKIEESADK
HHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TISVHLENQDNPITITGSHLLVSTGRVANVDGLGLEKAGVQYTTRGINTNARLQTTNKKI
EEEEEEECCCCCEEEECCEEEEECCCEECCCCCCCCCCCCEEEECCCCCCCEEEECCCEE
YAIGDVTGPYQFTHMASYQAGIALRNIAFKWPAKVDYKAVPWVTYTEPELAHVGLLASEA
EEEECCCCCEEHHHHHHHHCCEEEEEEEEECCCCCCCEECCEEEECCCCHHHHHHHHHHH
LKDPTLKITEFAFAEVDRAQAENKVNGKIKIITGKKAKILGVSIVGAHAGELILPWVIAV
HCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCHHHHHHHH
KERKSLRTFTDAIAAYPTFSEISKRVAGEYYKPFIFSSKIRTFVRWLNKLG
HHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKISAIKTWLPLLIIIVLLGLFLGLGLNKYVSFASLRDNHEWLIAITKSHFYLVSFVFII
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHH
IYTVAVALSIPGAIFLTLIGGFLFGILWGTFLVVLSATLGATILFFAVQSSLGEVFSKRA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGWVKRMRSGFKDNAFSYLLTLRLIPLFPFWVINIVSAVLGVSASTFIIATFIGIIPGSI
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCE
VYVSVGNGLGELFAASLQPNLGIIFEPKFILPLLGLAALSLIPVFYKKKGKQGTEKMKDK
EEEEECCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
DLFCDLAIIGGGSAGLSIAAGCSQLGLQVVLVEPNKMGGDCLNYGCIPSKTLLNTAKIFY
CCEEEEEEEECCCCCCHHHCCHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHE
QTKHSTVLGIQAKSVKIDFLQVMQQVHNVIACIAKNDSVERFTSLGVQVIQEAGHFIGPK
EECCCEEEEEEECCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCH
QFKLKRKIIRAKHFVIATGSSPAIPPIQNLNKVSYLTNETIFNLKVQPEHLIVIGGGPIG
HHHHHHHHHHHCEEEEECCCCCCCCCHHCCCHHHEECCCEEEEEEECCCEEEEECCCCCH
CELAQAFAMLGSKVTILEAFTILPKDDADCVAIIRSQLESMQIALYEQIKINKIEESADK
HHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TISVHLENQDNPITITGSHLLVSTGRVANVDGLGLEKAGVQYTTRGINTNARLQTTNKKI
EEEEEEECCCCCEEEECCEEEEECCCEECCCCCCCCCCCCEEEECCCCCCCEEEECCCEE
YAIGDVTGPYQFTHMASYQAGIALRNIAFKWPAKVDYKAVPWVTYTEPELAHVGLLASEA
EEEECCCCCEEHHHHHHHHCCEEEEEEEEECCCCCCCEECCEEEECCCCHHHHHHHHHHH
LKDPTLKITEFAFAEVDRAQAENKVNGKIKIITGKKAKILGVSIVGAHAGELILPWVIAV
HCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCHHHHHHHH
KERKSLRTFTDAIAAYPTFSEISKRVAGEYYKPFIFSSKIRTFVRWLNKLG
HHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]