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The map label for this gene is gmk

Identifier: 52842227

GI number: 52842227

Start: 2250383

End: 2251012

Strand: Reverse

Name: gmk

Synonym: lpg2010

Alternate gene names: 52842227

Gene position: 2251012-2250383 (Counterclockwise)

Preceding gene: 52842228

Following gene: 52842226

Centisome position: 66.25

GC content: 38.1

Gene sequence:

>630_bases
ATGGTTAGTGATAATTCAGGAAATTTATACATTGTTGCAGCACCCTCCGGAGGAGGGAAAACAAGTTTGGTGAAAAAACT
CATTGAAATGGTGGGTGAGATTGAAGTGTCAGTTTCTCATACGACCAGACCTATGAGACCTGGAGAAAAAGAAGGGGTGG
ATTATTTTTTCATTGATGAGAAACAATTTATTTCTATGGTGAATGAGGGGGCGTTTATTGAGCATGCCAAAGTATTTAAT
CATTGGTATGGTACCTCAGTTGCTCAAATTAACAAACGGTTACAATTTGGAATTGACGTCGTTCTTGATATTGATTGGCA
AGGAGCGGAGCAAATTAGACATGCCTATCCGGATGCAGTGAGTGTATTTATCATTCCTCCTTCTTTAGACGCATTAAAAG
AACGCTTGATGAACAGGCGACAAGATAAAGATCATGTGATTAGTGAGAGAATGACAAAAGCACAGGATGAACTTGGCCAT
TATCCTGAATTTGATTATCTGATTGTTAATGATGATTTTGAAAAGGCGGCAATGGAATTACAGTCGATAGTAATTGCCAA
TAGGCTTCGAATTGAAAAACAGGTAAATAAACAAGCCAAATTGCTTTCTTTCCTCTTGTCATCGCAGTAA

Upstream 100 bases:

>100_bases
GCTCAAAATCGGATTCAGCAGAGTTAACTTTATGTGCTGTTGAAATGAAAGTATTGATTGAGCAGATGCGTGAACAAATT
CAGAATTTTGAGTAAATGAT

Downstream 100 bases:

>100_bases
AATAAAAGATTTGAGTTAGTATTTGTTCTAATAACCTAGAGGTGGATTTTATGGCACGAGTAACAGTTGAAGATTGTTTA
GAACATGTTAAAAACCGGTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MVSDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDEKQFISMVNEGAFIEHAKVFN
HWYGTSVAQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAVSVFIIPPSLDALKERLMNRRQDKDHVISERMTKAQDELGH
YPEFDYLIVNDDFEKAAMELQSIVIANRLRIEKQVNKQAKLLSFLLSSQ

Sequences:

>Translated_209_residues
MVSDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDEKQFISMVNEGAFIEHAKVFN
HWYGTSVAQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAVSVFIIPPSLDALKERLMNRRQDKDHVISERMTKAQDELGH
YPEFDYLIVNDDFEKAAMELQSIVIANRLRIEKQVNKQAKLLSFLLSSQ
>Mature_209_residues
MVSDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDEKQFISMVNEGAFIEHAKVFN
HWYGTSVAQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAVSVFIIPPSLDALKERLMNRRQDKDHVISERMTKAQDELGH
YPEFDYLIVNDDFEKAAMELQSIVIANRLRIEKQVNKQAKLLSFLLSSQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=35.4285714285714, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=35.4285714285714, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=35.4285714285714, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI38570142, Length=189, Percent_Identity=30.1587301587302, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=30.635838150289, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI119943108, Length=151, Percent_Identity=29.8013245033113, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI261862237, Length=151, Percent_Identity=29.8013245033113, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI52630447, Length=200, Percent_Identity=29.5, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI119943106, Length=151, Percent_Identity=29.8013245033113, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=24.8677248677249, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21361598, Length=197, Percent_Identity=26.3959390862944, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI148539628, Length=153, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI148539578, Length=153, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=50.7389162561576, Blast_Score=212, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=34.8571428571429, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=34.8571428571429, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=27.0718232044199, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=38.7978142076503, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21356141, Length=188, Percent_Identity=34.0425531914894, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI161077626, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85724806, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640542, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45554489, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI116007136, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45554481, Length=188, Percent_Identity=30.3191489361702, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330166, Length=126, Percent_Identity=32.5396825396825, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330162, Length=126, Percent_Identity=32.5396825396825, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330164, Length=126, Percent_Identity=32.5396825396825, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554813, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554791, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161077754, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641280, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281360700, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641282, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554818, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554804, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161077752, Length=153, Percent_Identity=32.6797385620915, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23742; Mature: 23742

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDE
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECH
KQFISMVNEGAFIEHAKVFNHWYGTSVAQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAV
HHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCEE
SVFIIPPSLDALKERLMNRRQDKDHVISERMTKAQDELGHYPEFDYLIVNDDFEKAAMEL
EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHH
QSIVIANRLRIEKQVNKQAKLLSFLLSSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSDNSGNLYIVAAPSGGGKTSLVKKLIEMVGEIEVSVSHTTRPMRPGEKEGVDYFFIDE
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCEEEECH
KQFISMVNEGAFIEHAKVFNHWYGTSVAQINKRLQFGIDVVLDIDWQGAEQIRHAYPDAV
HHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCEE
SVFIIPPSLDALKERLMNRRQDKDHVISERMTKAQDELGHYPEFDYLIVNDDFEKAAMEL
EEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHH
QSIVIANRLRIEKQVNKQAKLLSFLLSSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA