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The map label for this gene is gad

Identifier: 52842202

GI number: 52842202

Start: 2224682

End: 2225995

Strand: Reverse

Name: gad

Synonym: lpg1985

Alternate gene names: 52842202

Gene position: 2225995-2224682 (Counterclockwise)

Preceding gene: 52842203

Following gene: 52842195

Centisome position: 65.51

GC content: 41.48

Gene sequence:

>1314_bases
TTGAATAGCATTCCTCATCTGATTTTAGGGGATATTATCACTCCTACACAAGCTGGGCAGAGTCTTCTTATCAAGAAAGG
CTATGTCTTGATCAATGGTGATAGCATTATTGAGGTGGGCGAGCAGGCTCATTTCAATAAAGAAATATCCTATACGGTGT
CAAATTATCCTGATCATTTAATCCTTCCTGGTTTAATTGATACACACAGCCATCTTTCCCAATACGCTATTTGTGGAGCT
GGTGATTTGCCATTGATGGATTGGTTAAACACTTTGGTTTTTCCCGCTGAAACCGCTTTCTCGAGTAATCTGCAAAGATG
CCAACGTCACGCTGAGCTTTATATGCATGCTTGCCTGGGTTCTGGCACAACGACTATCAATACGATGGTAACCAGCAGTC
GCCAAGCGACAGAAATAGTTTGTGATGTGGCAGCCCGCCTTGGTATCAGAGCGTTTATAGGCTTGGTTTTGATGGATAGA
AACGCACCTGATAATTTGCTTGTTGATTGTGCTCAGGCATTTAAAGATCTGACTGTTTTAAAAGATCGTTACCACGGTAA
AAATAATATACATATCACTGTTTCTCCCCGGTTTGCAGTGACTTGTTCTGCGGCTATGTTGAGGCAAGCAGGTGAGTTCG
CCCGTGCAAACAAGCTGATATTGCATACCCATCTTGATAAGGATGAAGGGTTTGATGAATTGATTCAAAGCTTGTTTAGT
ACAGCTCATGATTATTTTGATGTGTTTGAATCCACACAATGTATTGCTGATAAGACTGTGTTTGCCCATGGCACTTTGTT
ATCACTTCACGAAATGAAACGCATGGGAGACTATGCCAAGCAAGTTGGAATTAGCCATTGTCCCTCCAGTAATTTTTCTT
TTGCTATGGGAATGGCACCGGTTTCTTTTTTTAAAGGCTTGGGGATTGAGGTTGGATTGGGCTCAGACAGTGGTGGAGGG
GACAGTCTTTCTCTTTTTGATGAAATGCGTTCAGCGAGTTTTACTAATAAAGCATTATGGAGGCTTGATAAAAAGACAGC
TTTGATTGATGCTAAAACCTGGCTATATCATGCTACTCTTGGAGGAGCGAAATTGCTGGGATTAGAGAAGCAAATTGGCA
GCATTGAAGCAGGTAAAAAGGCGGATTTGATTATCCTGGATGACAGGAATAACTATCCTCTGGCAGAGCTTTCTTCTTTG
TCACAAGAGTTAGCCCTTGATGAACTTCAATATCGTCTGGCAAGAGTGATTGCCAGATCCTGCGAAAACAAGTTAGTTGC
TGTTTATATTGATGGAAAGAAAGTTTATCAGTAA

Upstream 100 bases:

>100_bases
AAGGAGTTCTTTTCACTATCGTATTTTTAATCCGAATTTCAGTTAATCCAGGAGGTTGTCTATACTTTTTGATAGTAAGA
AATAAATCTCAGGATATGAA

Downstream 100 bases:

>100_bases
CCACTAGGCCTAATGAGATTCGAGATAAAATCAAGAGGATTAATTCCCCAAAATTTTTGAATACGTTTTTAACGTGGAAG
CATCGGGTGACCGATAAACA

Product: guanine aminohydrolase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNSIPHLILGDIITPTQAGQSLLIKKGYVLINGDSIIEVGEQAHFNKEISYTVSNYPDHLILPGLIDTHSHLSQYAICGA
GDLPLMDWLNTLVFPAETAFSSNLQRCQRHAELYMHACLGSGTTTINTMVTSSRQATEIVCDVAARLGIRAFIGLVLMDR
NAPDNLLVDCAQAFKDLTVLKDRYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAPVSFFKGLGIEVGLGSDSGGG
DSLSLFDEMRSASFTNKALWRLDKKTALIDAKTWLYHATLGGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSL
SQELALDELQYRLARVIARSCENKLVAVYIDGKKVYQ

Sequences:

>Translated_437_residues
MNSIPHLILGDIITPTQAGQSLLIKKGYVLINGDSIIEVGEQAHFNKEISYTVSNYPDHLILPGLIDTHSHLSQYAICGA
GDLPLMDWLNTLVFPAETAFSSNLQRCQRHAELYMHACLGSGTTTINTMVTSSRQATEIVCDVAARLGIRAFIGLVLMDR
NAPDNLLVDCAQAFKDLTVLKDRYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAPVSFFKGLGIEVGLGSDSGGG
DSLSLFDEMRSASFTNKALWRLDKKTALIDAKTWLYHATLGGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSL
SQELALDELQYRLARVIARSCENKLVAVYIDGKKVYQ
>Mature_437_residues
MNSIPHLILGDIITPTQAGQSLLIKKGYVLINGDSIIEVGEQAHFNKEISYTVSNYPDHLILPGLIDTHSHLSQYAICGA
GDLPLMDWLNTLVFPAETAFSSNLQRCQRHAELYMHACLGSGTTTINTMVTSSRQATEIVCDVAARLGIRAFIGLVLMDR
NAPDNLLVDCAQAFKDLTVLKDRYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAPVSFFKGLGIEVGLGSDSGGG
DSLSLFDEMRSASFTNKALWRLDKKTALIDAKTWLYHATLGGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSL
SQELALDELQYRLARVIARSCENKLVAVYIDGKKVYQ

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=346, Percent_Identity=30.3468208092486, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1789249, Length=430, Percent_Identity=28.6046511627907, Blast_Score=172, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319963, Length=335, Percent_Identity=31.3432835820896, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24643849, Length=414, Percent_Identity=30.9178743961353, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48009; Mature: 48009

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIPHLILGDIITPTQAGQSLLIKKGYVLINGDSIIEVGEQAHFNKEISYTVSNYPDHL
CCCCCCHHHCCCCCCCCCCCEEEEECCEEEECCCCCEECCCHHCCCCCEEEEECCCCCCE
ILPGLIDTHSHLSQYAICGAGDLPLMDWLNTLVFPAETAFSSNLQRCQRHAELYMHACLG
EECCCCCCHHHHHHEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SGTTTINTMVTSSRQATEIVCDVAARLGIRAFIGLVLMDRNAPDNLLVDCAQAFKDLTVL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
KDRYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
HHHHCCCCCEEEEECCCEEEHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHH
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAP
HHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCH
VSFFKGLGIEVGLGSDSGGGDSLSLFDEMRSASFTNKALWRLDKKTALIDAKTWLYHATL
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEEHHHHEEEEEC
GGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSLSQELALDELQYRLARVIARS
CCHHEEEHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CENKLVAVYIDGKKVYQ
CCCCEEEEEECCCCCCC
>Mature Secondary Structure
MNSIPHLILGDIITPTQAGQSLLIKKGYVLINGDSIIEVGEQAHFNKEISYTVSNYPDHL
CCCCCCHHHCCCCCCCCCCCEEEEECCEEEECCCCCEECCCHHCCCCCEEEEECCCCCCE
ILPGLIDTHSHLSQYAICGAGDLPLMDWLNTLVFPAETAFSSNLQRCQRHAELYMHACLG
EECCCCCCHHHHHHEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SGTTTINTMVTSSRQATEIVCDVAARLGIRAFIGLVLMDRNAPDNLLVDCAQAFKDLTVL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
KDRYHGKNNIHITVSPRFAVTCSAAMLRQAGEFARANKLILHTHLDKDEGFDELIQSLFS
HHHHCCCCCEEEEECCCEEEHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHH
TAHDYFDVFESTQCIADKTVFAHGTLLSLHEMKRMGDYAKQVGISHCPSSNFSFAMGMAP
HHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCH
VSFFKGLGIEVGLGSDSGGGDSLSLFDEMRSASFTNKALWRLDKKTALIDAKTWLYHATL
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEEHHHHEEEEEC
GGAKLLGLEKQIGSIEAGKKADLIILDDRNNYPLAELSSLSQELALDELQYRLARVIARS
CCHHEEEHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CENKLVAVYIDGKKVYQ
CCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]