Click here to switch to the map view.

The map label for this gene is pilE

Identifier: 52842133

GI number: 52842133

Start: 2138278

End: 2138700

Strand: Reverse

Name: pilE

Synonym: lpg1915

Alternate gene names: 52842133

Gene position: 2138700-2138278 (Counterclockwise)

Preceding gene: 52842136

Following gene: 52842132

Centisome position: 62.94

GC content: 46.1

Gene sequence:

>423_bases
ATGGAGATGGTCATGAGACAAAAGGGTTTTACTTTAATTGAATTGATGATAGTCGTAGCGATTATCGGTATTTTGGCAGC
AATCGCTATACCAGCCTATCAAGATTACACAATACGAGCTCGTGTTACGGAAGGTCTGACCTTGGCAGATTCTGCAAAAC
TTGCCGTATCTGAAACGGCTATTACCAACAACGCGTTACCACCTACTCAGGCTGCAACGGGCTACGTGTCTCCCGCAGCT
ACGCCCAATGTACAATCAATTGCTATTGGTGCCAACGGTGTGATTACCATAACATATACCGCTTCAGCAGGTGGTGGTAC
CATAGTTATGACCCCAACCTTACAAGCTAACGGTGATGTAACCTGGACTTGTACGGGTGGTACATTATTGGCCAAATACC
GACCTGCCAGTTGCAGACCATAA

Upstream 100 bases:

>100_bases
TTTTACATGAAATGATTATTTAACATGTAAAATAATACAGGTTTAGAATATTGGCTGGTAGTTGGCATTATGCTTGCATT
ATACTAATGGATAGTTAACT

Downstream 100 bases:

>100_bases
TAGGATAAAGCCACTATAAAAACCGCCTTTCAATGGCGGTTTTTTATTTGCCCATGTTTTACCAATGACTTATTTACCTA
ACAGAAATGTTTTGAAAGAA

Product: Tfp pilus assembly protein, major type IV pilin class A

Products: NA

Alternate protein names: MS11 antigen; Pilin [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MEMVMRQKGFTLIELMIVVAIIGILAAIAIPAYQDYTIRARVTEGLTLADSAKLAVSETAITNNALPPTQAATGYVSPAA
TPNVQSIAIGANGVITITYTASAGGGTIVMTPTLQANGDVTWTCTGGTLLAKYRPASCRP

Sequences:

>Translated_140_residues
MEMVMRQKGFTLIELMIVVAIIGILAAIAIPAYQDYTIRARVTEGLTLADSAKLAVSETAITNNALPPTQAATGYVSPAA
TPNVQSIAIGANGVITITYTASAGGGTIVMTPTLQANGDVTWTCTGGTLLAKYRPASCRP
>Mature_140_residues
MEMVMRQKGFTLIELMIVVAIIGILAAIAIPAYQDYTIRARVTEGLTLADSAKLAVSETAITNNALPPTQAATGYVSPAA
TPNVQSIAIGANGVITITYTASAGGGTIVMTPTLQANGDVTWTCTGGTLLAKYRPASCRP

Specific function: This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells [H]

COG id: COG4969

COG function: function code NU; Tfp pilus assembly protein, major pilin PilA

Gene ontology:

Cell location: Fimbrium [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-Me-Phe pilin family [H]

Homologues:

Organism=Escherichia coli, GI1786297, Length=120, Percent_Identity=40.8333333333333, Blast_Score=77, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001082
- InterPro:   IPR012902
- InterPro:   IPR001120 [H]

Pfam domain/function: PF07963 N_methyl; PF00114 Pilin [H]

EC number: NA

Molecular weight: Translated: 14444; Mature: 14444

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00409 PROKAR_NTER_METHYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMVMRQKGFTLIELMIVVAIIGILAAIAIPAYQDYTIRARVTEGLTLADSAKLAVSETA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCCEEEEEEEE
ITNNALPPTQAATGYVSPAATPNVQSIAIGANGVITITYTASAGGGTIVMTPTLQANGDV
ECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCEEEEECCEECCCCE
TWTCTGGTLLAKYRPASCRP
EEEEECCEEEEEECCCCCCC
>Mature Secondary Structure
MEMVMRQKGFTLIELMIVVAIIGILAAIAIPAYQDYTIRARVTEGLTLADSAKLAVSETA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCCEEEEEEEE
ITNNALPPTQAATGYVSPAATPNVQSIAIGANGVITITYTASAGGGTIVMTPTLQANGDV
ECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCEEEEECCEECCCCE
TWTCTGGTLLAKYRPASCRP
EEEEECCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6148752; 2872674; 1671354; 1348857; 6143785; 7477282; 10048019 [H]