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The map label for this gene is hisS

Identifier: 52841774

GI number: 52841774

Start: 1708503

End: 1709783

Strand: Reverse

Name: hisS

Synonym: lpg1544

Alternate gene names: 52841774

Gene position: 1709783-1708503 (Counterclockwise)

Preceding gene: 52841775

Following gene: 52841773

Centisome position: 50.32

GC content: 38.17

Gene sequence:

>1281_bases
ATGGTGGTTGATAAAATTCAAGCTATCCGAGGAATGAATGATGTACTGCCTGATAGTACCTCGATATGGCGCTTTATAGA
ACAGACTTTTATAAATTGCCTCGTACGATATGGATACAAGGAAATACGTTTTCCAATTGTTGAGAATACACAGCTATTTA
AACGTACAATTGGTGAAATAACAGATATTGTTGAAAAAGAAATGTACACTTTTAACGATTTGAATGGTGATAGCATAACC
CTAAGGCCAGAAGGCACAGCCGGCTGTGTTCGTGCCTGTATAGAACATGGTTTATTACATAATCAACAACAAAAATTATG
GTACTTAGGCCCTATGTTTCGTCATGAACGTCCTCAGAAGGGTAGATACCGTCAATTTAACCAATTTGGGGTTGAGGCGC
TAGGAATTACTGGCACTGGCATTGAGCTTGAGCTGATCTCAATTTGCCGCAGATTATGGATCGACCTGGGTTTTTCTCAG
TCAGTTCAATTACAAGTTAATTCATTAGGTGAAATAAATGAACGTCAGAAATATCGCTCTATCCTGGTAGAGTATCTACG
CGATCATTTTCAGATACTTGATGAAGACAGTAAGAGGCGATTGGATAAAAACCCTTTGAGAGTTCTTGATAGTAAAAACC
CTGATCTTCAACAGCTCATTCAAAATGCCCCTAAGTTAATTGATGTTCTTGGTGATGATAGCAGAGAACACTTTCAATCG
TTCTGCAACGGATTGGAAACACTTGGTATTCCTTATTCCATCAACCCTGTATTGGTAAGAGGATTAGATTATTATGGCCA
AACGGTGTTTGAATGGGTAACAGACCAATTAGGAAGTCAAGCTACAATATGTGCAGGAGGTAGATATGATATGTTGGTGG
AGTTCCTTGGCGGAGCACCCACACCTGCAGTTGGGTTTGCTTTAGGATTGGAAAGAATATTTCTTTTAATGGAAACTTTA
AACTTGTTGAATGAAAGTAACAATAAACAATCAATATTTATCATTGCTACTAATGAAGAGGCCATATTGAAAGCGCTTGT
CATGGCAGAGTCAATTCGAAATGCTCATCCATCTCTTGATGTCATTACCAATACGGCAGGCGGTGGTTTTAAAAGCCAAT
TTAAAAAGGCCGATAAAAGCGGGGCTCGCTTGGCTTTGATTCTTGGGGAAGACGAAATAGCCAAGGAATATGTAAGCATT
AAAGATTTGAGAACTGAAATAGAACAAATATCAATACCGATGACCAAAATAAATGAATTTTTGCAAGATTATCTAGCTTA
A

Upstream 100 bases:

>100_bases
TCAATCAGTGAAACCAGTTCGGAAATTAAATTGACTGATTTATCAAAAATGGAATCGTTATTAACGCCCAACAATACACA
AATGACACCTTTGGAGAAAA

Downstream 100 bases:

>100_bases
GGGCAGGAGAATATTATATGTCTGTTTACATGACGGAAGAAGAACAATTAGAGATTATAAAAAAATGGTGGAAACGATAT
GGCAATATGATAACTATTTT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MVVDKIQAIRGMNDVLPDSTSIWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEITDIVEKEMYTFNDLNGDSIT
LRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKGRYRQFNQFGVEALGITGTGIELELISICRRLWIDLGFSQ
SVQLQVNSLGEINERQKYRSILVEYLRDHFQILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSREHFQS
FCNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPTPAVGFALGLERIFLLMETL
NLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDVITNTAGGGFKSQFKKADKSGARLALILGEDEIAKEYVSI
KDLRTEIEQISIPMTKINEFLQDYLA

Sequences:

>Translated_426_residues
MVVDKIQAIRGMNDVLPDSTSIWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEITDIVEKEMYTFNDLNGDSIT
LRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKGRYRQFNQFGVEALGITGTGIELELISICRRLWIDLGFSQ
SVQLQVNSLGEINERQKYRSILVEYLRDHFQILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSREHFQS
FCNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPTPAVGFALGLERIFLLMETL
NLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDVITNTAGGGFKSQFKKADKSGARLALILGEDEIAKEYVSI
KDLRTEIEQISIPMTKINEFLQDYLA
>Mature_426_residues
MVVDKIQAIRGMNDVLPDSTSIWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEITDIVEKEMYTFNDLNGDSIT
LRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQKGRYRQFNQFGVEALGITGTGIELELISICRRLWIDLGFSQ
SVQLQVNSLGEINERQKYRSILVEYLRDHFQILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSREHFQS
FCNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAPTPAVGFALGLERIFLLMETL
NLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLDVITNTAGGGFKSQFKKADKSGARLALILGEDEIAKEYVSI
KDLRTEIEQISIPMTKINEFLQDYLA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=425, Percent_Identity=56.2352941176471, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71993686, Length=465, Percent_Identity=22.3655913978495, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993693, Length=465, Percent_Identity=22.3655913978495, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48407; Mature: 48407

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVDKIQAIRGMNDVLPDSTSIWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEI
CCCHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHH
TDIVEKEMYTFNDLNGDSITLRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQK
HHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHEEECCHHHCCCCCC
GRYRQFNQFGVEALGITGTGIELELISICRRLWIDLGFSQSVQLQVNSLGEINERQKYRS
CHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHH
ILVEYLRDHFQILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSREHFQS
HHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHH
FCNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAP
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCC
TPAVGFALGLERIFLLMETLNLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCE
VITNTAGGGFKSQFKKADKSGARLALILGEDEIAKEYVSIKDLRTEIEQISIPMTKINEF
EEECCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQDYLA
HHHHCC
>Mature Secondary Structure
MVVDKIQAIRGMNDVLPDSTSIWRFIEQTFINCLVRYGYKEIRFPIVENTQLFKRTIGEI
CCCHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHH
TDIVEKEMYTFNDLNGDSITLRPEGTAGCVRACIEHGLLHNQQQKLWYLGPMFRHERPQK
HHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHEEECCHHHCCCCCC
GRYRQFNQFGVEALGITGTGIELELISICRRLWIDLGFSQSVQLQVNSLGEINERQKYRS
CHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHH
ILVEYLRDHFQILDEDSKRRLDKNPLRVLDSKNPDLQQLIQNAPKLIDVLGDDSREHFQS
HHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHH
FCNGLETLGIPYSINPVLVRGLDYYGQTVFEWVTDQLGSQATICAGGRYDMLVEFLGGAP
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCC
TPAVGFALGLERIFLLMETLNLLNESNNKQSIFIIATNEEAILKALVMAESIRNAHPSLD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCE
VITNTAGGGFKSQFKKADKSGARLALILGEDEIAKEYVSIKDLRTEIEQISIPMTKINEF
EEECCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQDYLA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA