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The map label for this gene is hpt [H]

Identifier: 52841749

GI number: 52841749

Start: 1682632

End: 1683201

Strand: Reverse

Name: hpt [H]

Synonym: lpg1519

Alternate gene names: 52841749

Gene position: 1683201-1682632 (Counterclockwise)

Preceding gene: 52841750

Following gene: 52841738

Centisome position: 49.54

GC content: 39.3

Gene sequence:

>570_bases
ATGACCATTCCTGATAAAATTAAAGCTGTATATGAAAAATCAACCTGTTTATACACATCTAACGAAGTTGAAGCAGCACT
GGACAGAATGGCAATAAAAATTCATGAAACACTACAGGATAAAAACCCTGTAATTATTTGCGTGATGGTAGGAGGTCTAG
TTCCATTAGGTAATCTATTGCATCGTTTGGATTTTCCTCTAGAGGTGGATTATGTTCATGCTACGCGTTATCGAGGTGAT
TTAACGGGAGGGGACATTCTTTGGAAAGTGAGACCATCAAGCAATCTTGCAGGACGAACAGTCCTGGTCGTAGATGACAT
TCTTGATGGTGGTATAACCTTGGCTGCCATAATTAATGAAATCAAAGCCATGGGGGCTGCGGAAGTTTATAGTGCTGTAT
TAGTTGATAAATATCGTAAACGTGTCCCCAATGGTTTGCAAAAGGCTGATTTTGTCGGTTTACAAGTAGAGGATCATTAT
ATTTTTGGCTATGGTATGGATTATCACGAGTACTTACGTAATGCGCCAGGGATTTTTATCGTTCATCCGGATCATGAGGC
AAGTAAATAA

Upstream 100 bases:

>100_bases
CTTGAGCCATGGCAATAAAGTAAGGCCTTTCCCTGGATCAGGAAAGATAAAAGATTAACTTCGTTTAGCCTGTATAAACA
ACTTCTAAGGAAATAAATAA

Downstream 100 bases:

>100_bases
TTTATTGCAAAAATTGCATGCATTTTTCGGTTGGCTTTGGATGAGAAAAATAATATCCTTGTCCATAATGACAGCCCAGT
TTTTTTAAAAATTCGAGTTG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MTIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLLHRLDFPLEVDYVHATRYRGD
LTGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINEIKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHY
IFGYGMDYHEYLRNAPGIFIVHPDHEASK

Sequences:

>Translated_189_residues
MTIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLLHRLDFPLEVDYVHATRYRGD
LTGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINEIKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHY
IFGYGMDYHEYLRNAPGIFIVHPDHEASK
>Mature_188_residues
TIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLLHRLDFPLEVDYVHATRYRGDL
TGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINEIKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHYI
FGYGMDYHEYLRNAPGIFIVHPDHEASK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=171, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI9910262, Length=172, Percent_Identity=26.1627906976744, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87081689, Length=160, Percent_Identity=26.25, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510817, Length=163, Percent_Identity=30.6748466257669, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21025; Mature: 20893

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLL
CCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHH
HRLDFPLEVDYVHATRYRGDLTGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINE
HHCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHH
IKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHYIFGYGMDYHEYLRNAPGIFI
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECEEEEEECCCHHHHHHCCCCEEE
VHPDHEASK
ECCCCCCCC
>Mature Secondary Structure 
TIPDKIKAVYEKSTCLYTSNEVEAALDRMAIKIHETLQDKNPVIICVMVGGLVPLGNLL
CCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHH
HRLDFPLEVDYVHATRYRGDLTGGDILWKVRPSSNLAGRTVLVVDDILDGGITLAAIINE
HHCCCCEEEEEEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHH
IKAMGAAEVYSAVLVDKYRKRVPNGLQKADFVGLQVEDHYIFGYGMDYHEYLRNAPGIFI
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECEEEEEECCCHHHHHHCCCCEEE
VHPDHEASK
ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]