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The map label for this gene is kefC [H]

Identifier: 52841737

GI number: 52841737

Start: 1667605

End: 1668777

Strand: Reverse

Name: kefC [H]

Synonym: lpg1507

Alternate gene names: 52841737

Gene position: 1668777-1667605 (Counterclockwise)

Preceding gene: 52841738

Following gene: 52841736

Centisome position: 49.11

GC content: 38.45

Gene sequence:

>1173_bases
ATGCATGATGGCTCTGTATTTTACACTATATTTTTGATATTTGCTGGAGCTGCTTTTTTTTCTACTTTGGTATTGTACAC
CAAACAGTCATTATTGGTTGCTTATATAACACTTGGTGCTATCTTAGGTCCTTGGGGATTCAAACTTGTATCCGATGTGA
CGGTTGTCAAGCAGATAGGTGACATCGGAATAGTATTCTTGCTTTTCTTATTAGGTTTGCATTTACAGCCCCAGAATTTG
ATTCATATGCTAAGAAAAGTAACCTGGATTGCAATCGTAAGCTCAATTCTGTTTGCTGCACTTGCCTACGGAATTGGCAG
ATGGTTTGGCCTCACAGTGACTGAGTCATTGATATTGGGCGGAGCCATGATGTTTTCAAGTACTATTATTGGCTTGAAAT
TATTACCAACAACCATTTTACATCACCAGCATACTGGTGAAGTCATGATTAGCGTACTCCTAATGCAGGACGTTATAGCT
ATAGTGCTTTTGATATTACTTAATAGTGCCCATCAGGATGGGAACCTGTCAATCAGTGATTTCATCCTGGTTATTATCGC
GCTACCGGCCCTGTGCTTGTTCTCTTTTTTATTTGAAAGATACATCCTGATAAAACTGCTGGCACGTTTTGATAGAACTC
AGGAATACGTTTTTCTACTCTCCATAGGATGGTGTTTGGGGATATCCGTTTTAGCACAAACAATAGGCTTATCAGAAGAT
ATTGGCGCTTTTATAGCAGGAGTAGCTTTGGCATCAAGCCCAATTTCATTGTTCATTGCTGAAAGTTTAAAGCCATTAAG
AGATTTTTTCCTTGTAATGTTCTTTTTTTCGATAGGTGCTACTTTTAATTTTGGATTTGGAGCTCAGGTAGTTATCCCAG
CGGTGATATTAGCGACATTGATACTGATTATTAAGCCGTTGCTATTTTATATATTGCTTGCCCGTTCTGGTGAGAAAAAA
CAAGTGGCAAAAGAAGTAGGAATTCGCTTGGGGCAGGGGAGTGAGTTTTCTTTATTGGTTGCGAGCATCGCCTTGAGTAC
AAACCTGATTTCAGAAGTCGCCTCCAATTTAATCCAGGCAACTACTATTTTAACTTTTATCGTTTCATCGTATCTTGTTG
TATTGAAATATCCAACACCTATAGCTTTATCTGAAAAAATGCGTAAGGATTAA

Upstream 100 bases:

>100_bases
TTATTAATAAACAATAATTAATAGCTAATTAATAGATTAATGGATAAAATTGGCTTTATAATTCAATTTTAACTACCTTT
TCTTAAGAGGTATTCAATCA

Downstream 100 bases:

>100_bases
TCAAATGAAATTACTGGTAATAGTATTATGCTTGCTCAGTGAACGGTTTTTAATCCATTCAGTGTCCTATCAGCGATTTT
CCTGGTTTAATAACTACTGT

Product: sodium/hydrogen antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIGDIGIVFLLFLLGLHLQPQNL
IHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILGGAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIA
IVLLILLNSAHQDGNLSISDFILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATLILIIKPLLFYILLARSGEKK
QVAKEVGIRLGQGSEFSLLVASIALSTNLISEVASNLIQATTILTFIVSSYLVVLKYPTPIALSEKMRKD

Sequences:

>Translated_390_residues
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIGDIGIVFLLFLLGLHLQPQNL
IHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILGGAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIA
IVLLILLNSAHQDGNLSISDFILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATLILIIKPLLFYILLARSGEKK
QVAKEVGIRLGQGSEFSLLVASIALSTNLISEVASNLIQATTILTFIVSSYLVVLKYPTPIALSEKMRKD
>Mature_390_residues
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIGDIGIVFLLFLLGLHLQPQNL
IHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILGGAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIA
IVLLILLNSAHQDGNLSISDFILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATLILIIKPLLFYILLARSGEKK
QVAKEVGIRLGQGSEFSLLVASIALSTNLISEVASNLIQATTILTFIVSSYLVVLKYPTPIALSEKMRKD

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=349, Percent_Identity=25.214899713467, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786232, Length=363, Percent_Identity=26.7217630853994, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789749, Length=371, Percent_Identity=27.2237196765499, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786685, Length=366, Percent_Identity=27.8688524590164, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 42612; Mature: 42612

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA