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The map label for this gene is holB

Identifier: 52841630

GI number: 52841630

Start: 1544952

End: 1545857

Strand: Direct

Name: holB

Synonym: lpg1400

Alternate gene names: 52841630

Gene position: 1544952-1545857 (Clockwise)

Preceding gene: 52841629

Following gene: 52841631

Centisome position: 45.47

GC content: 35.1

Gene sequence:

>906_bases
ATGATTACTTATCAAGAACAATGGCAGAAAATGCAAATGGCCTTGGCGATAAGACGAATTCCTCAAGCCATGCTATTTTC
GGGTTCTTTGCATTGTGGTCTTATAGAATTTACAAATCAAGTGATCAAATTACTCTTGTGTAAAATAAAACAGAATGAGC
CTTGTTTGACTTGCATGGATTGCCAAATGATAGAGCGTTTTGAGCATCCGGATGTGGAATGGATTAAGCCTGAAAGAAGC
GGTGGTATTATTAAAATTGATCAAATTAGGGGATTGCAGAGTACGGCGTTTCTAACACCACAGAGGACTAATCATAAACT
TATAATTATCGAATCAGCTGAATCAATGAATATTGCTGCATCAAATGCCTTATTGAAAATTCTGGAAGAGCCAGCGCAAC
ATACTATCTTTATTTTGTTAGCGCAACAAATTGGCAATATACCCCCCACCGTATTGAGCCGATGCCAAATAACGCAATTT
GCTGTTTTTGATGAGTTGCCTTGCAACAATTTATTGGCTTTAGGAGAGTACTATACTCAGGAATTGAATAGCACAATGGT
CTTCAAGCATTCAGAATCTATTTTAGAAGGCTTGATTGCAATTATTGAGCGAAGAGAGCATCCATGCACTTTGGCTGCAC
AATGGATTCAACATGAATTAAGTGCTTTTTTGTGGTTTTTATATTTGATCTATTCTCAACTACAGTATATGCATTTGTTT
CGAGTGGCTTATTCTGGTACGTTAACAAAACAATTGAATAAGCTATCCTCATTACTCAATCCGGTTATGATTTTTGCCCA
AGTAGATAAAATCAATACTTTGTTAAGAAAATTAAGCCATAATATGAATATAAATCATACATTGGTCTTGGAAGATTTAT
TATTTTCTTTGGTTGTTGATTATTAA

Upstream 100 bases:

>100_bases
AACAAAACCCGGAAATTATAATGATTGATGCTAACAGGTCTTTGGAAGAGGTTCAATCTTCCATTCAATCAGTAATCGAG
GAGTTTATAGAGCATAACCT

Downstream 100 bases:

>100_bases
TTGAGTTTAAAGGAATTAAACCATTGAGTGTAAACCGAGTTTTTTATTAAGCAACTGAAGTGAGCAATATGATTAGTTAA
AACAGGACTATTCAAGGAGG

Product: DNA polymerase III, delta prime subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MITYQEQWQKMQMALAIRRIPQAMLFSGSLHCGLIEFTNQVIKLLLCKIKQNEPCLTCMDCQMIERFEHPDVEWIKPERS
GGIIKIDQIRGLQSTAFLTPQRTNHKLIIIESAESMNIAASNALLKILEEPAQHTIFILLAQQIGNIPPTVLSRCQITQF
AVFDELPCNNLLALGEYYTQELNSTMVFKHSESILEGLIAIIERREHPCTLAAQWIQHELSAFLWFLYLIYSQLQYMHLF
RVAYSGTLTKQLNKLSSLLNPVMIFAQVDKINTLLRKLSHNMNINHTLVLEDLLFSLVVDY

Sequences:

>Translated_301_residues
MITYQEQWQKMQMALAIRRIPQAMLFSGSLHCGLIEFTNQVIKLLLCKIKQNEPCLTCMDCQMIERFEHPDVEWIKPERS
GGIIKIDQIRGLQSTAFLTPQRTNHKLIIIESAESMNIAASNALLKILEEPAQHTIFILLAQQIGNIPPTVLSRCQITQF
AVFDELPCNNLLALGEYYTQELNSTMVFKHSESILEGLIAIIERREHPCTLAAQWIQHELSAFLWFLYLIYSQLQYMHLF
RVAYSGTLTKQLNKLSSLLNPVMIFAQVDKINTLLRKLSHNMNINHTLVLEDLLFSLVVDY
>Mature_301_residues
MITYQEQWQKMQMALAIRRIPQAMLFSGSLHCGLIEFTNQVIKLLLCKIKQNEPCLTCMDCQMIERFEHPDVEWIKPERS
GGIIKIDQIRGLQSTAFLTPQRTNHKLIIIESAESMNIAASNALLKILEEPAQHTIFILLAQQIGNIPPTVLSRCQITQF
AVFDELPCNNLLALGEYYTQELNSTMVFKHSESILEGLIAIIERREHPCTLAAQWIQHELSAFLWFLYLIYSQLQYMHLF
RVAYSGTLTKQLNKLSSLLNPVMIFAQVDKINTLLRKLSHNMNINHTLVLEDLLFSLVVDY

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=143, Percent_Identity=31.4685314685315, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 34676; Mature: 34676

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITYQEQWQKMQMALAIRRIPQAMLFSGSLHCGLIEFTNQVIKLLLCKIKQNEPCLTCMD
CCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
CQMIERFEHPDVEWIKPERSGGIIKIDQIRGLQSTAFLTPQRTNHKLIIIESAESMNIAA
HHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHEEECCCCCCCEEEEEECCCCCCHHH
SNALLKILEEPAQHTIFILLAQQIGNIPPTVLSRCQITQFAVFDELPCNNLLALGEYYTQ
HHHHHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ELNSTMVFKHSESILEGLIAIIERREHPCTLAAQWIQHELSAFLWFLYLIYSQLQYMHLF
HHCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAYSGTLTKQLNKLSSLLNPVMIFAQVDKINTLLRKLSHNMNINHTLVLEDLLFSLVVD
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
Y
C
>Mature Secondary Structure
MITYQEQWQKMQMALAIRRIPQAMLFSGSLHCGLIEFTNQVIKLLLCKIKQNEPCLTCMD
CCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
CQMIERFEHPDVEWIKPERSGGIIKIDQIRGLQSTAFLTPQRTNHKLIIIESAESMNIAA
HHHHHHCCCCCCEEECCCCCCCEEEECCCCCCCHHEEECCCCCCCEEEEEECCCCCCHHH
SNALLKILEEPAQHTIFILLAQQIGNIPPTVLSRCQITQFAVFDELPCNNLLALGEYYTQ
HHHHHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ELNSTMVFKHSESILEGLIAIIERREHPCTLAAQWIQHELSAFLWFLYLIYSQLQYMHLF
HHCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAYSGTLTKQLNKLSSLLNPVMIFAQVDKINTLLRKLSHNMNINHTLVLEDLLFSLVVD
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]