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The map label for this gene is tmk

Identifier: 52841629

GI number: 52841629

Start: 1544317

End: 1544955

Strand: Direct

Name: tmk

Synonym: lpg1399

Alternate gene names: 52841629

Gene position: 1544317-1544955 (Clockwise)

Preceding gene: 52841628

Following gene: 52841630

Centisome position: 45.45

GC content: 36.78

Gene sequence:

>639_bases
ATGTCATCGTTAACCGGGAAATTGATAGTTATTGAAGGTTTGGAGGGAGCAGGAAAATCTACAGCTGTCAATTTAGTTGT
TGAACTGTTATCCCAAAAAAAAATCAGTACTATAACCACGAGAGAACCCGGAGGAACAAAAATAGGTGAAATTTTAAGAA
GTATTATTAAAAATCCAGAGTACAATAATGTTCTGGATGACAGAAGCGAATTACTTCTCCTGTATGCCGCAAGAATACAA
CTGATTGAGCAAGTGATCAAACCCGCTTTAAATGTGGGGCAGTGGGTCATAGCTGATCGATTTGAGCTTTCCACTTTAGC
TTATCAGGGAGGGGGCCGCAAAATGGATATGCGGGTTATTAATGAGCTATCGAATTTCTGTTTAAAAGGATTCAAACCTG
ATCTTACTTTATATTTAGACATTAATCCCGAGCTTGGCATGATAAGAGCCAAATCAAGGGGAAAATTTGACAGAATTGAG
CAGGAATCTATTGAGTTTTTTCATAGAATACATGATACATATCATATTCTTGTTAAACAAAACCCGGAAATTATAATGAT
TGATGCTAACAGGTCTTTGGAAGAGGTTCAATCTTCCATTCAATCAGTAATCGAGGAGTTTATAGAGCATAACCTATGA

Upstream 100 bases:

>100_bases
ATTTATACTTTGTTGCCAAAGGAGATGGTACTCATCAATTCTCCGAAACTTATGAGCAACAAAGACAAGCAATTAACCAA
TACAGACGCAAGGATTATTA

Downstream 100 bases:

>100_bases
TTACTTATCAAGAACAATGGCAGAAAATGCAAATGGCCTTGGCGATAAGACGAATTCCTCAAGCCATGCTATTTTCGGGT
TCTTTGCATTGTGGTCTTAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHILVKQNPEIIMIDANRSLEEVQSSIQSVIEEFIEHNL

Sequences:

>Translated_212_residues
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQ
LIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIE
QESIEFFHRIHDTYHILVKQNPEIIMIDANRSLEEVQSSIQSVIEEFIEHNL
>Mature_211_residues
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPEYNNVLDDRSELLLLYAARIQL
IEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVINELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQ
ESIEFFHRIHDTYHILVKQNPEIIMIDANRSLEEVQSSIQSVIEEFIEHNL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI42544174, Length=214, Percent_Identity=30.3738317757009, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=50.9708737864078, Blast_Score=210, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6322517, Length=218, Percent_Identity=27.5229357798165, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573735, Length=207, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24010; Mature: 23879

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPE
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCHHHHHHEECCCCCCHHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHILVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
NPEIIMIDANRSLEEVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLTGKLIVIEGLEGAGKSTAVNLVVELLSQKKISTITTREPGGTKIGEILRSIIKNPE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCC
YNNVLDDRSELLLLYAARIQLIEQVIKPALNVGQWVIADRFELSTLAYQGGGRKMDMRVI
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCHHHHHHEECCCCCCHHHHHH
NELSNFCLKGFKPDLTLYLDINPELGMIRAKSRGKFDRIEQESIEFFHRIHDTYHILVKQ
HHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
NPEIIMIDANRSLEEVQSSIQSVIEEFIEHNL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA