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The map label for this gene is hemF

Identifier: 52841447

GI number: 52841447

Start: 1341674

End: 1342624

Strand: Reverse

Name: hemF

Synonym: lpg1215

Alternate gene names: 52841447

Gene position: 1342624-1341674 (Counterclockwise)

Preceding gene: 52841465

Following gene: 52841443

Centisome position: 39.52

GC content: 41.64

Gene sequence:

>951_bases
ATGCAGAGTCTCATCATGCCAATCTCAAAGACACTTCCTTATAATGCAATAGAGCAAATTAAATCTTATCTGCTCCAACT
CCAAAACACAATTTGTGTCTCACTGGAGTCAATTGATGGCAAAACCAGATTCCATGAGGATTCCTGGCAGCGAGCTGCTG
GAGGTGGAGGAAAAACAAGAATAATGGCGAATGGGAATGTCTTTGAAAAAGCCGGCGTCAATTTTTCACATGTTTCAGGG
GAACAATTACCAGCATCAGCCAGTGCACATAGAGAAGAATTGGCAGGAAGACATTTCAGCGCATTAGGGGTATCTCTGGT
CATTCATCCTCAAAACCCCTATGTGCCAACAACACATGCCAATGTTCGATTTTTTGTCGCTGAAAAGGAGGATTCAGAAC
CAGTCTGGTGGTTTGGTGGAGGATTTGATTTAACCCCTTATTATGGATTTGTTGAAGACTGTGAGCATTGGCATCAAACG
GCATTAAATGCCTGTTTACCTTTTGGAGAAACGATTTACCCAAAATTCAAGCGTTGGTGCGATGATTATTTTTTTATTAA
GCACAGAAATGAAGCACGTGGGATTGGCGGCTTATTTTTTGATGATTACAATGAAATCAGCTTTGATCACAGCTTTGAAC
TCATGCGTAGCATAGGCGATCATTTTATTCTGGCTTATGAACCCATAGTGGCTCGCCGTAAAGACATCCCTTTTGGCAAC
AGGGAAAAAGCATTTCAGAATTACCGCAGAGGCCGTTATGCGGAGTTCAATTTAGTCTATGATCGAGGCACTTTATTTGG
TCTGCAATCTGGCGGAAGGACTGAGTCCATATTGATGTCCCTGCCTCCCATTGTTCATTGGGAATACAATTGGCATCCTG
AAAAAGGCAGTGATGAAGAAAAATTATACACGGATTTTTTACCTGCAAAAGATTGGTTGAAAAAGGAGTAA

Upstream 100 bases:

>100_bases
ACTGAAACATAAAAATGATAAAAAAACCTATTTAAACAAAGCAAACATTGTGCCAATATCCAAAAAATGAGAAAATGAAG
CATCCAAGCGCTAATTCCCT

Downstream 100 bases:

>100_bases
AACACCAAACTCAAAAATAAATGATATCCTTCTCCCCTTACCTGAAAATTTCGAGGAGCCAGTATACATGCAGTAAATAA
GCACCGCGAAACGTTTACAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MQSLIMPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSG
EQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQT
ALNACLPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGN
REKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE

Sequences:

>Translated_316_residues
MQSLIMPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSG
EQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQT
ALNACLPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGN
REKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE
>Mature_316_residues
MQSLIMPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSG
EQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQT
ALNACLPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGN
REKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=310, Percent_Identity=43.8709677419355, Blast_Score=269, Evalue=2e-72,
Organism=Escherichia coli, GI1788777, Length=295, Percent_Identity=65.0847457627119, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320249, Length=316, Percent_Identity=44.9367088607595, Blast_Score=270, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17864388, Length=307, Percent_Identity=47.2312703583062, Blast_Score=278, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36393; Mature: 36393

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLIMPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTR
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCEE
IMANGNVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHA
EEECCCEEHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCC
NVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACLPFGETIYPKFKRWC
CEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGN
CCEEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHCCCCCCCC
REKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEE
HHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCCHH
KLYTDFLPAKDWLKKE
HHHHHCCCCHHHHCCC
>Mature Secondary Structure
MQSLIMPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTR
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHCCCCCCEE
IMANGNVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHA
EEECCCEEHHCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCC
NVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACLPFGETIYPKFKRWC
CEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGN
CCEEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEECHHHHHCCCCCCCC
REKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEE
HHHHHHHHHCCCEEEEEEEEECCEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCCCHH
KLYTDFLPAKDWLKKE
HHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA