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The map label for this gene is hisG

Identifier: 52841433

GI number: 52841433

Start: 1328312

End: 1329250

Strand: Reverse

Name: hisG

Synonym: lpg1200

Alternate gene names: 52841433

Gene position: 1329250-1328312 (Counterclockwise)

Preceding gene: 52841436

Following gene: 52841432

Centisome position: 39.12

GC content: 41.43

Gene sequence:

>939_bases
TTGTTTAAGCTTTGGTACAGGCGGTTATCGTTTAATAGCCGAAAGATTGGAGAAGTTGTGAAAAATCGTTTACGTCTGGC
CTTACAAAAAAAAGGCCGATTATCAGATGAATCTTTAAATCTCCTACAACGCTGTGGTTTAAAGTTTCGTATTAAACCAA
ACGCATTATTAACTCATGTTGATAATTTTCCAATCGATTTACTATTTGTTCGCGATGATGACATCCCTACTCTCGTATTC
GACAGTTTATGTGATGGTGGCATCGTGGGAGAAAATGTGCTGCTGGAAGCTTCTTTTAACAGACCAGACAAAGCCTATAG
AAAAATATTGGCATTAGGCAGTTGTACTTGTCGTTTATCGATAGCAGTACCAGAAGCATTCGACTATCAAGGAGCCGGTA
GTTTGGATGGGAAGCGAATTGCAACCAGCTATCCAAATTTACTCAACAATTATCTTGCTGAACGAAAAATTAGTGCGGAA
ATTCTGACATTATCCGGCTCGGTTGAGGTAGCGCCACGAATGGGAATGGCTGATGTCATATGCGACTTGGTATCCACTGG
CCAAACACTCGAAGATAACAAACTCAAAGAAGTCGATACTGTTCTTAACAGTCAGGCCGTCTTTATTCAAACTCAGAGAC
AATTGGATCCTGATATTCAAGAGTTGTTTGCCATGCTTGCCAGAAGAATCCAGGCTGTCCAGCAAGCTCAGGAAAGAAAA
TACATAGTTTTTCATGCGCCCAAATCCGCCCTTGAGCGAATTGCTCAGAAATTACCAGGCGCTGAGTCCCCAACCATTCT
TCCATTACCGGGAAACAATGAAAAAGTTGCAGTGCATGTAGTCTCCAGTGAAGGTGTGTTTTGGAATACGTTAGAGACAA
TTCAATATTTAGGTGCCAGCTCCATCCTGGTATTACCCATTGAAAAAATGCTGGAGTAA

Upstream 100 bases:

>100_bases
ATCGATGGCAAATAGTTCCTTTGCTACGCCAGGGCATCCCATACAGAACGATTCATGAAGAAACAGGGGTCAGTGTAACA
ACCATCACGCGAGTTGCGCG

Downstream 100 bases:

>100_bases
TTCATATGTTAACAATTAAAAACTGGCAATTACTTTCTGAAAACGATAAAAAGCTATGCCTTTCAAGACCGCGACAGAGT
TCTGCAATAAAAGAAAATGT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MFKLWYRRLSFNSRKIGEVVKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLVF
DSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGKRIATSYPNLLNNYLAERKISAE
ILTLSGSVEVAPRMGMADVICDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERK
YIVFHAPKSALERIAQKLPGAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE

Sequences:

>Translated_312_residues
MFKLWYRRLSFNSRKIGEVVKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLVF
DSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGKRIATSYPNLLNNYLAERKISAE
ILTLSGSVEVAPRMGMADVICDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERK
YIVFHAPKSALERIAQKLPGAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE
>Mature_312_residues
MFKLWYRRLSFNSRKIGEVVKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHVDNFPIDLLFVRDDDIPTLVF
DSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLSIAVPEAFDYQGAGSLDGKRIATSYPNLLNNYLAERKISAE
ILTLSGSVEVAPRMGMADVICDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERK
YIVFHAPKSALERIAQKLPGAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGASSILVLPIEKMLE

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=295, Percent_Identity=53.5593220338983, Blast_Score=303, Evalue=9e-84,
Organism=Saccharomyces cerevisiae, GI6320896, Length=292, Percent_Identity=30.8219178082192, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34843; Mature: 34843

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKLWYRRLSFNSRKIGEVVKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHV
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHHEEEC
DNFPIDLLFVRDDDIPTLVFDSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLS
CCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEE
IAVPEAFDYQGAGSLDGKRIATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADVI
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHHHHH
CDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERK
HHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
YIVFHAPKSALERIAQKLPGAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGAS
EEEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEECCCEEEHHHHHHHHCCCC
SILVLPIEKMLE
CEEEEEHHHHCC
>Mature Secondary Structure
MFKLWYRRLSFNSRKIGEVVKNRLRLALQKKGRLSDESLNLLQRCGLKFRIKPNALLTHV
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHHEEEC
DNFPIDLLFVRDDDIPTLVFDSLCDGGIVGENVLLEASFNRPDKAYRKILALGSCTCRLS
CCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEE
IAVPEAFDYQGAGSLDGKRIATSYPNLLNNYLAERKISAEILTLSGSVEVAPRMGMADVI
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHHHHH
CDLVSTGQTLEDNKLKEVDTVLNSQAVFIQTQRQLDPDIQELFAMLARRIQAVQQAQERK
HHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
YIVFHAPKSALERIAQKLPGAESPTILPLPGNNEKVAVHVVSSEGVFWNTLETIQYLGAS
EEEEECCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEECCCEEEHHHHHHHHCCCC
SILVLPIEKMLE
CEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA