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The map label for this gene is trpC

Identifier: 52841069

GI number: 52841069

Start: 913515

End: 914291

Strand: Reverse

Name: trpC

Synonym: lpg0833

Alternate gene names: 52841069

Gene position: 914291-913515 (Counterclockwise)

Preceding gene: 52841070

Following gene: 52841068

Centisome position: 26.91

GC content: 35.91

Gene sequence:

>777_bases
ATGAATAGTATCCTGGAACGAATAGCAAAACATAAACTAGAAGAAGTTGCAGTTGCGAAAAAAAATAAGCCTTTACATGT
TCTGTCAAAACAACAGCCGGGGGAAATGCGTGACTTCATAACTGCTTTAAAATCCAATACCTCACCTGCAGTCATAGCTG
AGATAAAAAAGGCTTCTCCAAGCAAAGGTTTAATTCGAAAAGATTTTAATGTTGCAGAAATTGCCAAGATTTATACCCAA
AATGGCGCAAGATGCTTATCCGTTTTAACGGATATTGAGTTTTTTCAAGGTCATCCTGATTATTTGGCTTTAGCAAAATC
AAAAACCACTTTGCCCGTATTGCGTAAAGACTTTATTATTGATTCTTATCAAATCTATGAAAGCCTTGTCTTGGGTGCTG
ATTGCATTTTACTGATTGTCGCATTATTAGATGATGTTCAATTAATGGATTTTTGCCAACTGGCTCAAGAACTTAAAATG
TCTGTTTTGGTTGAAAGCCACACGCAAGATGAATTAGAAAGAGCATTACGCTTACCCACCCCCCTTATAGGCATTAATAA
CCGCAGCCTACACAACTTTAAAACAGACATTCAACTGAGTATCCAATTAAAACAATTTGTTCCTAAAGATAAAATTATTA
TTACTGAAAGCGGAATCAACACCCGTGAAGACATAAAATTAATGCAATCCCATGGCATTAATGCCTTTTTGATTGGAGAG
AGTTTAATGAGGGCAGATAACATCGGGAAAGCATTACAGAAACTAATGACTGACTAA

Upstream 100 bases:

>100_bases
GCCATAGAGGAAGCAAGAATTGCCATTGATAGTGGTAAGGCAAATCTTTGTTTTAACAAACTCCGATTATTGACCCAAAC
TTTAAATAAAGAATCAAATC

Downstream 100 bases:

>100_bases
ATAAACTACTCAAAACCTGGCTCAGGAGTTTGACTCGGCTCAGGCTCAGGCAACTCGGGATAACCAGGCTCCAGAGGCTC
TGGATTATCAGGGTACTCCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEMRDFITALKSNTSPAVIAEIKKASPSKGLIRKDFNVAEIAKIYTQ
NGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFIIDSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKM
SVLVESHTQDELERALRLPTPLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
SLMRADNIGKALQKLMTD

Sequences:

>Translated_258_residues
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEMRDFITALKSNTSPAVIAEIKKASPSKGLIRKDFNVAEIAKIYTQ
NGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFIIDSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKM
SVLVESHTQDELERALRLPTPLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
SLMRADNIGKALQKLMTD
>Mature_258_residues
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEMRDFITALKSNTSPAVIAEIKKASPSKGLIRKDFNVAEIAKIYTQ
NGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFIIDSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKM
SVLVESHTQDELERALRLPTPLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
SLMRADNIGKALQKLMTD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=256, Percent_Identity=38.671875, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=229, Percent_Identity=38.8646288209607, Blast_Score=155, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_LEGPA (Q5X6S0)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123223.1
- HSSP:   P00909
- ProteinModelPortal:   Q5X6S0
- SMR:   Q5X6S0
- STRING:   Q5X6S0
- GeneID:   3118984
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0895
- LegioList:   lpp0895
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   LPNE297246:LPP0895-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28950; Mature: 28950

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEMRDFITALKSNTSPAVIAEIKKASP
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
SKGLIRKDFNVAEIAKIYTQNGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFII
CCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
DSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKMSVLVESHTQDELERALRLPT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
CEEECCCCCCCCCCCCEEEEEEHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHH
SLMRADNIGKALQKLMTD
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSILERIAKHKLEEVAVAKKNKPLHVLSKQQPGEMRDFITALKSNTSPAVIAEIKKASP
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
SKGLIRKDFNVAEIAKIYTQNGARCLSVLTDIEFFQGHPDYLALAKSKTTLPVLRKDFII
CCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
DSYQIYESLVLGADCILLIVALLDDVQLMDFCQLAQELKMSVLVESHTQDELERALRLPT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PLIGINNRSLHNFKTDIQLSIQLKQFVPKDKIIITESGINTREDIKLMQSHGINAFLIGE
CEEECCCCCCCCCCCCEEEEEEHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEHHH
SLMRADNIGKALQKLMTD
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA