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The map label for this gene is czcR [H]

Identifier: 52840952

GI number: 52840952

Start: 780630

End: 781301

Strand: Reverse

Name: czcR [H]

Synonym: lpg0715

Alternate gene names: 52840952

Gene position: 781301-780630 (Counterclockwise)

Preceding gene: 52840954

Following gene: 52840951

Centisome position: 22.99

GC content: 37.2

Gene sequence:

>672_bases
ATGCGATTATTAATTGTTGAAGACCATAAAAGAACGGCTGATTTTATCTGTAAAGGATTTAATGAATATCAATTTCACGC
AGATGCTGTATACGATGGTGCGGAAGCAATCTATCGAATCTCAGAAATTAACTACGATGCTGTTGTTTTAGACGTTATGT
TACCCATAATGGATGGATGGGCTGTACTTGAAAAGATTCGTGAACTAAAACCTGATTTACCCGTTTTAATGCTCTCTGCC
TGCGACGATGTCGATAGTCGTGTGAAAGGGCTTGAAATGGGGGCCTATGATTACCTTGTTAAACCTTTTTCCTTCAACGA
GCTCCTTGCCCGAATAAAATCTTTACTACGAAGAAAACCCAAAGAGAATCCTATCTTATTAAAGATTGATGATTTAACTC
TAAACTTACAAAAGCATACAGCAATACGAGGCGAGAAAAAGTTGCCTTTAACAGCAAAAGAATTCATGTTATTGACGTTT
ATGTTGAAACGAAATGGTGAAGTACTTTCAAGGACAGTCATTGCTGAACAAGTTTGGGACATTAATTTTGACACGAATAC
CAATATCATTGATGTAGCGATCAAGCGTTTAAGGGAAAAAGTGGATAATGATCATCCTACTAAATTGATCCATACTGTCA
GAGGAGTCGGCTATGTATTGGAGATTCGCTAA

Upstream 100 bases:

>100_bases
TCAGAAGAGTGACATCAAGATTACAAAATTGTAATCTAATTCATTATGATGATTAGCATTTTTATGCTACAATTGAGCAT
AATTTGAACACAACGGCATT

Downstream 100 bases:

>100_bases
ATCAATGTCTATTACTAACCGCTTATTACTGATATTTATTGGTTCAACCGTACTGATATTGTCTATTATCACAGGGTTAA
TCTATCCTCCAATGAAAGAA

Product: two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLIVEDHKRTADFICKGFNEYQFHADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGWAVLEKIRELKPDLPVLMLSA
CDDVDSRVKGLEMGAYDYLVKPFSFNELLARIKSLLRRKPKENPILLKIDDLTLNLQKHTAIRGEKKLPLTAKEFMLLTF
MLKRNGEVLSRTVIAEQVWDINFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR

Sequences:

>Translated_223_residues
MRLLIVEDHKRTADFICKGFNEYQFHADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGWAVLEKIRELKPDLPVLMLSA
CDDVDSRVKGLEMGAYDYLVKPFSFNELLARIKSLLRRKPKENPILLKIDDLTLNLQKHTAIRGEKKLPLTAKEFMLLTF
MLKRNGEVLSRTVIAEQVWDINFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR
>Mature_223_residues
MRLLIVEDHKRTADFICKGFNEYQFHADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGWAVLEKIRELKPDLPVLMLSA
CDDVDSRVKGLEMGAYDYLVKPFSFNELLARIKSLLRRKPKENPILLKIDDLTLNLQKHTAIRGEKKLPLTAKEFMLLTF
MLKRNGEVLSRTVIAEQVWDINFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=48, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=47.2477064220183, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=36.3636363636364, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=36.3636363636364, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=31.5789473684211, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.5964125560538, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=35, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=32.6086956521739, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=34.070796460177, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=30.8695652173913, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=29.1304347826087, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.1929824561404, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790299, Length=106, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=25.974025974026, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25742; Mature: 25742

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLIVEDHKRTADFICKGFNEYQFHADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGW
CEEEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
AVLEKIRELKPDLPVLMLSACDDVDSRVKGLEMGAYDYLVKPFSFNELLARIKSLLRRKP
HHHHHHHHHCCCCCEEEEHHCCCHHHHHHHCCCCCHHHEECCCCHHHHHHHHHHHHHCCC
KENPILLKIDDLTLNLQKHTAIRGEKKLPLTAKEFMLLTFMLKRNGEVLSRTVIAEQVWD
CCCCEEEEEECEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
INFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MRLLIVEDHKRTADFICKGFNEYQFHADAVYDGAEAIYRISEINYDAVVLDVMLPIMDGW
CEEEEEECCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
AVLEKIRELKPDLPVLMLSACDDVDSRVKGLEMGAYDYLVKPFSFNELLARIKSLLRRKP
HHHHHHHHHCCCCCEEEEHHCCCHHHHHHHCCCCCHHHEECCCCHHHHHHHHHHHHHCCC
KENPILLKIDDLTLNLQKHTAIRGEKKLPLTAKEFMLLTFMLKRNGEVLSRTVIAEQVWD
CCCCEEEEEECEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
INFDTNTNIIDVAIKRLREKVDNDHPTKLIHTVRGVGYVLEIR
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]