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The map label for this gene is irlS [H]

Identifier: 52840951

GI number: 52840951

Start: 779576

End: 780667

Strand: Reverse

Name: irlS [H]

Synonym: lpg0714

Alternate gene names: 52840951

Gene position: 780667-779576 (Counterclockwise)

Preceding gene: 52840952

Following gene: 52840946

Centisome position: 22.98

GC content: 34.71

Gene sequence:

>1092_bases
CTGTCAGAGGAGTCGGCTATGTATTGGAGATTCGCTAAATCAATGTCTATTACTAACCGCTTATTACTGATATTTATTGG
TTCAACCGTACTGATATTGTCTATTATCACAGGGTTAATCTATCCTCCAATGAAAGAATTACTCCATCATACTCATTTGA
ATAATGAGCATTATAATTATTTATTAACACGAATTTGTATTAAAAATTTCTTTGTTGGACTCTGGTTTTCTACTTTGATA
ATCATTCTTGCCAGTTATTTGCTCGCAAAAAAAAGCATGAGGCCAATTAAAATATTCACTAAAGAACTTGCATCGATTAA
TGCTTCATCACTAGAGAAACGATTACCTTACACAGGGAATCCCAAAGAACTGGAAGAATTAGCTTCGACTTGTAATGACA
TGCTCTTTCGAATAGAAAGTGCATTTAGCCATATAAAGCAGTTTTCAGCCAGTATAGCTCATGAATTACGAAATCCCATT
CATTACCTCAGAACTGCCACCGAAATTACCCTGACTAAACCACAAACGATTGAAACCTATCAACATGTATTACAAACGCA
TCTCGAAGAATATCAAAGTTTAACCCAACTTATAGATAATCTGATCTTTTTAACTCGCTGTGAGCACGGCCAACTTCAAT
TAAATTTAAGAACATTATCTGCAAACCACTTAATCAGTTCAATTATTGAGTATTATTATTCAATAGCTCAAGAAAAGGGC
ATAGAAATTCAAGTTTTTGGTGAGGCTCAGATTGAAGTAGATGAGCATTTATTTAAGCGCGTTATTTCAAATTTAATAGA
CAACAGTCTGACCTATACCAACAAAGGCGGAAGAATACTAATCATCATAGAAAAAAGAACAGACGACAGCATTCAAATCC
GTATAAAAGACAATGGAATTGGTATATCAAAAGAACACTTACCTCTTTTATATCACGGATTTTATCGAGTAGATTATAGT
ACTAACAAAGAAAACGCAGGCCTTGGTTTAGGTTTGGCCATTGCTAAATCAATCATGGAACACCATAAAGGCCAGCTTGC
GGTAGATAGCAAGATAGGTTTAGGCACCACTGTTATATTAACCCTACCATGA

Upstream 100 bases:

>100_bases
TGGGACATTAATTTTGACACGAATACCAATATCATTGATGTAGCGATCAAGCGTTTAAGGGAAAAAGTGGATAATGATCA
TCCTACTAAATTGATCCATA

Downstream 100 bases:

>100_bases
AAAAGCTTTTTGAAATTGAATAATATATGTATTTCATCTATCCGAAACCATAAGGGATCGGATATTGCACTAAGCTATTC
CAAAAACATAGATTTTTCCC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSEESAMYWRFAKSMSITNRLLLIFIGSTVLILSIITGLIYPPMKELLHHTHLNNEHYNYLLTRICIKNFFVGLWFSTLI
IILASYLLAKKSMRPIKIFTKELASINASSLEKRLPYTGNPKELEELASTCNDMLFRIESAFSHIKQFSASIAHELRNPI
HYLRTATEITLTKPQTIETYQHVLQTHLEEYQSLTQLIDNLIFLTRCEHGQLQLNLRTLSANHLISSIIEYYYSIAQEKG
IEIQVFGEAQIEVDEHLFKRVISNLIDNSLTYTNKGGRILIIIEKRTDDSIQIRIKDNGIGISKEHLPLLYHGFYRVDYS
TNKENAGLGLGLAIAKSIMEHHKGQLAVDSKIGLGTTVILTLP

Sequences:

>Translated_363_residues
MSEESAMYWRFAKSMSITNRLLLIFIGSTVLILSIITGLIYPPMKELLHHTHLNNEHYNYLLTRICIKNFFVGLWFSTLI
IILASYLLAKKSMRPIKIFTKELASINASSLEKRLPYTGNPKELEELASTCNDMLFRIESAFSHIKQFSASIAHELRNPI
HYLRTATEITLTKPQTIETYQHVLQTHLEEYQSLTQLIDNLIFLTRCEHGQLQLNLRTLSANHLISSIIEYYYSIAQEKG
IEIQVFGEAQIEVDEHLFKRVISNLIDNSLTYTNKGGRILIIIEKRTDDSIQIRIKDNGIGISKEHLPLLYHGFYRVDYS
TNKENAGLGLGLAIAKSIMEHHKGQLAVDSKIGLGTTVILTLP
>Mature_362_residues
SEESAMYWRFAKSMSITNRLLLIFIGSTVLILSIITGLIYPPMKELLHHTHLNNEHYNYLLTRICIKNFFVGLWFSTLII
ILASYLLAKKSMRPIKIFTKELASINASSLEKRLPYTGNPKELEELASTCNDMLFRIESAFSHIKQFSASIAHELRNPIH
YLRTATEITLTKPQTIETYQHVLQTHLEEYQSLTQLIDNLIFLTRCEHGQLQLNLRTLSANHLISSIIEYYYSIAQEKGI
EIQVFGEAQIEVDEHLFKRVISNLIDNSLTYTNKGGRILIIIEKRTDDSIQIRIKDNGIGISKEHLPLLYHGFYRVDYST
NKENAGLGLGLAIAKSIMEHHKGQLAVDSKIGLGTTVILTLP

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=287, Percent_Identity=33.7979094076655, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1788279, Length=260, Percent_Identity=30.3846153846154, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786600, Length=283, Percent_Identity=27.208480565371, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=28.5198555956679, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=26.4227642276423, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=26.3537906137184, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=29.8245614035088, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=25.764192139738, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=28.82096069869, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=23.9130434782609, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=358, Percent_Identity=24.0223463687151, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=264, Percent_Identity=26.1363636363636, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=258, Percent_Identity=28.6821705426357, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=25.9090909090909, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=25.1028806584362, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=219, Percent_Identity=25.1141552511416, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=294, Percent_Identity=22.7891156462585, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=248, Percent_Identity=22.1774193548387, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41461; Mature: 41330

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEESAMYWRFAKSMSITNRLLLIFIGSTVLILSIITGLIYPPMKELLHHTHLNNEHYNY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHH
LLTRICIKNFFVGLWFSTLIIILASYLLAKKSMRPIKIFTKELASINASSLEKRLPYTGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCC
PKELEELASTCNDMLFRIESAFSHIKQFSASIAHELRNPIHYLRTATEITLTKPQTIETY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHH
QHVLQTHLEEYQSLTQLIDNLIFLTRCEHGQLQLNLRTLSANHLISSIIEYYYSIAQEKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCC
IEIQVFGEAQIEVDEHLFKRVISNLIDNSLTYTNKGGRILIIIEKRTDDSIQIRIKDNGI
CEEEEECCCEEHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCCEEEEEEECCCC
GISKEHLPLLYHGFYRVDYSTNKENAGLGLGLAIAKSIMEHHKGQLAVDSKIGLGTTVIL
CCCHHCCCCEEECEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEE
TLP
ECC
>Mature Secondary Structure 
SEESAMYWRFAKSMSITNRLLLIFIGSTVLILSIITGLIYPPMKELLHHTHLNNEHYNY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHH
LLTRICIKNFFVGLWFSTLIIILASYLLAKKSMRPIKIFTKELASINASSLEKRLPYTGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCC
PKELEELASTCNDMLFRIESAFSHIKQFSASIAHELRNPIHYLRTATEITLTKPQTIETY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHH
QHVLQTHLEEYQSLTQLIDNLIFLTRCEHGQLQLNLRTLSANHLISSIIEYYYSIAQEKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCC
IEIQVFGEAQIEVDEHLFKRVISNLIDNSLTYTNKGGRILIIIEKRTDDSIQIRIKDNGI
CEEEEECCCEEHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCCEEEEEEECCCC
GISKEHLPLLYHGFYRVDYSTNKENAGLGLGLAIAKSIMEHHKGQLAVDSKIGLGTTVIL
CCCHHCCCCEEECEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEE
TLP
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]