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The map label for this gene is tolC [H]

Identifier: 52840936

GI number: 52840936

Start: 763337

End: 764704

Strand: Reverse

Name: tolC [H]

Synonym: lpg0699

Alternate gene names: 52840936

Gene position: 764704-763337 (Counterclockwise)

Preceding gene: 52840937

Following gene: 52840935

Centisome position: 22.51

GC content: 41.59

Gene sequence:

>1368_bases
ATGAGAAAATCTCTGTTTTGTTGGATTTTAACTTTAGGTGTTTCAACCCATGTGTTTGCAACAGACCTAATGGATATCTA
TCAACAAGCTCTGGAGAACGATACCATTTTTAAAGAGGCATATGATACCTATATGTCCAGCACAGAAGCCATACCTCAAG
CTCGTGCCGCTCTTTACCCTCAAGTAGGCCTTGGTTCACAAGCTGGTCGCAATTATCAGGATGCTGTTGCTGGAGCTTTC
AGTGCCAATCAATACTATGGAAGTTATTTGTGGCAAGTCAATGCTTCTCAGGCACTGTTTAACTATCAGGCATGGGCCAA
GGTAGCCCAGGCTAAAGCCTCTGTTAAAGCAGCACAAGCCACTTTCAATGATGCAGCACAGAATTTAATTCTAAGAACGG
CCAAAGCCTATTTTGATGTCTTGTTTGCTAAAGACACTTTAGACTTTGCCGAAGCAAAAAAACGGGCGAACAAAAGACAA
TATGATCAAGCAACTCAACGTTTTCAAGTTGGCCTGGATGCCATCACTTCTGTCTATGAAGCAAAAGCAGCGTATGATCA
ATCCATAGCGACAGTTATCGCCGCCCGCAATAATCAGATTAATCAGAGTGAAAATTTACGAAAACTTACTAATCACGTAT
ACGAAACACTTGCGCCACTCAAAGACAGCAAAATTCCTCTTGTTAAGCCAGAGCCAAATGACGTGAATCAATGGATAGAT
ACCGGACTTAAGCAAAACTATAAATTATATGCTGCAAAATATAATCTTGAGGTAGCAAAAGACAATGTAAAAGCGATCTC
TGCCGGCAACTGGCCAGTTTTTTCACTACAGAGCAACGCAAGCCAGGTACATAATAATGCATCCGGCAATACCGTTTTTA
TTCCGTCAAAACAAACCCAGGCTAATATTGCAATCGCGATGAATTTTCCTGTTTTTCAAGGCGGCCTGGTCCAGGCTCAA
ACCCGACAAGCTCAATATGGCTTTCAGTCTACGAGTGAAAAACTGGAACAAACGTATCGCGATGTGATTGTAAACAGCCG
CATTGCTTTCAATACCATCACTGATGGGATCAGCAAAGTAAAGGCGGACAGACAAACGGTCATCTCCGTGCAAAATTCTT
TGCAAAGTACTGAAGCTCAATTTGAAGTTGGTACTCGAACCATGGTAGATGTGGTCAATGCTCAACAAAGATTGTTTGAA
GCACAGGAACAATTAGCCCGGGATCAATACGACTTGATTAATTCCATACTTACGCTGAAATACCTTGCAGGGACATTAAA
CGTTAATGATCTCGAACAGATTAACTCATGGTTAGCAACTACACGTGTCAATGGATTTTCACCCGTAGATAACAAAACCT
CCAAATAA

Upstream 100 bases:

>100_bases
ATAATGCAATCTGGACAGAATCCATGCTTTTTGAAACGGATATACCTCCTCTGGTAGATCAATTGAAACCGAAAGAATTT
GTTTTCTAGGGAAAACTCGA

Downstream 100 bases:

>100_bases
CAAATTTAGGTTTTTTTATGTCTTCCAATCCTTCTTCAGTTGAAAAAAAATTACTTCATTATACAGGTAAAGCCATAGCT
GATTTTAATATGATCCAGCG

Product: outer membrane protein TolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRKSLFCWILTLGVSTHVFATDLMDIYQQALENDTIFKEAYDTYMSSTEAIPQARAALYPQVGLGSQAGRNYQDAVAGAF
SANQYYGSYLWQVNASQALFNYQAWAKVAQAKASVKAAQATFNDAAQNLILRTAKAYFDVLFAKDTLDFAEAKKRANKRQ
YDQATQRFQVGLDAITSVYEAKAAYDQSIATVIAARNNQINQSENLRKLTNHVYETLAPLKDSKIPLVKPEPNDVNQWID
TGLKQNYKLYAAKYNLEVAKDNVKAISAGNWPVFSLQSNASQVHNNASGNTVFIPSKQTQANIAIAMNFPVFQGGLVQAQ
TRQAQYGFQSTSEKLEQTYRDVIVNSRIAFNTITDGISKVKADRQTVISVQNSLQSTEAQFEVGTRTMVDVVNAQQRLFE
AQEQLARDQYDLINSILTLKYLAGTLNVNDLEQINSWLATTRVNGFSPVDNKTSK

Sequences:

>Translated_455_residues
MRKSLFCWILTLGVSTHVFATDLMDIYQQALENDTIFKEAYDTYMSSTEAIPQARAALYPQVGLGSQAGRNYQDAVAGAF
SANQYYGSYLWQVNASQALFNYQAWAKVAQAKASVKAAQATFNDAAQNLILRTAKAYFDVLFAKDTLDFAEAKKRANKRQ
YDQATQRFQVGLDAITSVYEAKAAYDQSIATVIAARNNQINQSENLRKLTNHVYETLAPLKDSKIPLVKPEPNDVNQWID
TGLKQNYKLYAAKYNLEVAKDNVKAISAGNWPVFSLQSNASQVHNNASGNTVFIPSKQTQANIAIAMNFPVFQGGLVQAQ
TRQAQYGFQSTSEKLEQTYRDVIVNSRIAFNTITDGISKVKADRQTVISVQNSLQSTEAQFEVGTRTMVDVVNAQQRLFE
AQEQLARDQYDLINSILTLKYLAGTLNVNDLEQINSWLATTRVNGFSPVDNKTSK
>Mature_455_residues
MRKSLFCWILTLGVSTHVFATDLMDIYQQALENDTIFKEAYDTYMSSTEAIPQARAALYPQVGLGSQAGRNYQDAVAGAF
SANQYYGSYLWQVNASQALFNYQAWAKVAQAKASVKAAQATFNDAAQNLILRTAKAYFDVLFAKDTLDFAEAKKRANKRQ
YDQATQRFQVGLDAITSVYEAKAAYDQSIATVIAARNNQINQSENLRKLTNHVYETLAPLKDSKIPLVKPEPNDVNQWID
TGLKQNYKLYAAKYNLEVAKDNVKAISAGNWPVFSLQSNASQVHNNASGNTVFIPSKQTQANIAIAMNFPVFQGGLVQAQ
TRQAQYGFQSTSEKLEQTYRDVIVNSRIAFNTITDGISKVKADRQTVISVQNSLQSTEAQFEVGTRTMVDVVNAQQRLFE
AQEQLARDQYDLINSILTLKYLAGTLNVNDLEQINSWLATTRVNGFSPVDNKTSK

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=428, Percent_Identity=36.4485981308411, Blast_Score=238, Evalue=5e-64,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50692; Mature: 50692

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8801424 [H]