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The map label for this gene is tyrP [H]

Identifier: 52840893

GI number: 52840893

Start: 704468

End: 705658

Strand: Reverse

Name: tyrP [H]

Synonym: lpg0656

Alternate gene names: 52840893

Gene position: 705658-704468 (Counterclockwise)

Preceding gene: 52840894

Following gene: 52840892

Centisome position: 20.77

GC content: 39.63

Gene sequence:

>1191_bases
ATGCGTTCAAGATTTATAGGCGGCATCTTATTGATAGTTGGTACCTCCATTGGTGGAGGGATGTTGGCTTTACCAGTAGC
TAATGCAGCAACCGGTTTTTGGCAATCTTCTCTGTTTCTTCTTATCTGCTGGGCCTTTATGACCTTTGGTGCCTTTTTCA
TCCTGGAAGCAAATCTCTATTTGTCCAGAGGAAAACACATGGTTTCCATGGCCAAGGCAACTCTTGGCGATTATGGGTTA
CTTACTGCCTGGATTAGTTACCTTTTCTTATTGTATACCTTGCTTTCCGCTTACATTTCCGGCGGCGCTGATGTATTGAA
CAGTCTATTGTCCAAAGCCAATTGGCATCTCAGTGATTGGCAGGCAAGTTCGTTATTTACTTTAATTTTTGGCCTGGTGG
TATATGGTGGCATCCATTCCGTTGATGTTGCTAACCGCGCTCTCATGTTCGGTAAATTAGCCGTTTACTGCATACTTGTT
ATCATGATTGCCCCACACATCGAATTTCACTATTTTCAACATGGTGATTATCAACAAATTGGTGGCGCAATTATGATTTT
AATTACTTCCTTTGGTTTTGCTATTATCGTGCCAAATCTGAGAGATTATTTTGATGATGACATTAAGACATTAAAAAAAG
TCATTTTTATTGGTTCATTAATACCTTTGATATGTTACATAGCCTGGGATGCCGTAATTATTGGTTCACTCCCTTCAGCA
GGCACTAGCGGACTTGAAAGTCTAATGCAAAATCCGCGTACAACCAGCGCGTTAGCCAGTTTGTTAACTGATAAAGTTGA
AAATACCACAATCAGCGCCCTCTTTAATTTTTTTACCTCCATTTGCATGTTAACTGCCTTCTTAGGTGTATCACTTTGTT
TATTTAGTTTTCTTGCTGATGGCTTAAAATTGCGAGAGCGAGGCCGCCATGGAATTGGCTTATTTGTTTTGACTTTTTTG
CCGCCTTTACTAATCGTCATTTATTATCCGGGGGCCTATATTTATGCTCTGCGCTACGCCGGTATATTTTGCATCATATT
ACTACTGTTATTGCCAGCTCTAATGTGTTATTTTGGCAGAAAGCGTTACAAATCACCCTTTTGGGTTCCAGGGGGTAAAA
TATCACAGTTCGCAGTGATTATTATTTCTGTAGTCTTATTGACACATGAATTTATTGCGCTTTTTAAATAA

Upstream 100 bases:

>100_bases
CATGGAAGCGCCCAGAACAGAAGAATCGAGATCCAGTGGTTTACAAGCCCTGCTCAACCCCCACAACCACAAATGGCTTA
TGTAAAATAAAGGTTTATTA

Downstream 100 bases:

>100_bases
GAATGATTAATGTTATTACTGGCGTTATTTTTACTTTGATAGCAGTAAAACATTAAAACCTGATAAACAGGATGTATAAA
TTGAACGCCAGGTCATTTGC

Product: tryptophan/tyrosine permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MRSRFIGGILLIVGTSIGGGMLALPVANAATGFWQSSLFLLICWAFMTFGAFFILEANLYLSRGKHMVSMAKATLGDYGL
LTAWISYLFLLYTLLSAYISGGADVLNSLLSKANWHLSDWQASSLFTLIFGLVVYGGIHSVDVANRALMFGKLAVYCILV
IMIAPHIEFHYFQHGDYQQIGGAIMILITSFGFAIIVPNLRDYFDDDIKTLKKVIFIGSLIPLICYIAWDAVIIGSLPSA
GTSGLESLMQNPRTTSALASLLTDKVENTTISALFNFFTSICMLTAFLGVSLCLFSFLADGLKLRERGRHGIGLFVLTFL
PPLLIVIYYPGAYIYALRYAGIFCIILLLLLPALMCYFGRKRYKSPFWVPGGKISQFAVIIISVVLLTHEFIALFK

Sequences:

>Translated_396_residues
MRSRFIGGILLIVGTSIGGGMLALPVANAATGFWQSSLFLLICWAFMTFGAFFILEANLYLSRGKHMVSMAKATLGDYGL
LTAWISYLFLLYTLLSAYISGGADVLNSLLSKANWHLSDWQASSLFTLIFGLVVYGGIHSVDVANRALMFGKLAVYCILV
IMIAPHIEFHYFQHGDYQQIGGAIMILITSFGFAIIVPNLRDYFDDDIKTLKKVIFIGSLIPLICYIAWDAVIIGSLPSA
GTSGLESLMQNPRTTSALASLLTDKVENTTISALFNFFTSICMLTAFLGVSLCLFSFLADGLKLRERGRHGIGLFVLTFL
PPLLIVIYYPGAYIYALRYAGIFCIILLLLLPALMCYFGRKRYKSPFWVPGGKISQFAVIIISVVLLTHEFIALFK
>Mature_396_residues
MRSRFIGGILLIVGTSIGGGMLALPVANAATGFWQSSLFLLICWAFMTFGAFFILEANLYLSRGKHMVSMAKATLGDYGL
LTAWISYLFLLYTLLSAYISGGADVLNSLLSKANWHLSDWQASSLFTLIFGLVVYGGIHSVDVANRALMFGKLAVYCILV
IMIAPHIEFHYFQHGDYQQIGGAIMILITSFGFAIIVPNLRDYFDDDIKTLKKVIFIGSLIPLICYIAWDAVIIGSLPSA
GTSGLESLMQNPRTTSALASLLTDKVENTTISALFNFFTSICMLTAFLGVSLCLFSFLADGLKLRERGRHGIGLFVLTFL
PPLLIVIYYPGAYIYALRYAGIFCIILLLLLPALMCYFGRKRYKSPFWVPGGKISQFAVIIISVVLLTHEFIALFK

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=405, Percent_Identity=33.0864197530864, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789552, Length=360, Percent_Identity=27.7777777777778, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790145, Length=413, Percent_Identity=27.3607748184019, Blast_Score=117, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43667; Mature: 43667

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSRFIGGILLIVGTSIGGGMLALPVANAATGFWQSSLFLLICWAFMTFGAFFILEANLY
CCCHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRGKHMVSMAKATLGDYGLLTAWISYLFLLYTLLSAYISGGADVLNSLLSKANWHLSDW
HHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
QASSLFTLIFGLVVYGGIHSVDVANRALMFGKLAVYCILVIMIAPHIEFHYFQHGDYQQI
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHH
GGAIMILITSFGFAIIVPNLRDYFDDDIKTLKKVIFIGSLIPLICYIAWDAVIIGSLPSA
HHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GTSGLESLMQNPRTTSALASLLTDKVENTTISALFNFFTSICMLTAFLGVSLCLFSFLAD
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLKLRERGRHGIGLFVLTFLPPLLIVIYYPGAYIYALRYAGIFCIILLLLLPALMCYFGR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRYKSPFWVPGGKISQFAVIIISVVLLTHEFIALFK
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSRFIGGILLIVGTSIGGGMLALPVANAATGFWQSSLFLLICWAFMTFGAFFILEANLY
CCCHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRGKHMVSMAKATLGDYGLLTAWISYLFLLYTLLSAYISGGADVLNSLLSKANWHLSDW
HHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
QASSLFTLIFGLVVYGGIHSVDVANRALMFGKLAVYCILVIMIAPHIEFHYFQHGDYQQI
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCHHHH
GGAIMILITSFGFAIIVPNLRDYFDDDIKTLKKVIFIGSLIPLICYIAWDAVIIGSLPSA
HHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GTSGLESLMQNPRTTSALASLLTDKVENTTISALFNFFTSICMLTAFLGVSLCLFSFLAD
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLKLRERGRHGIGLFVLTFLPPLLIVIYYPGAYIYALRYAGIFCIILLLLLPALMCYFGR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRYKSPFWVPGGKISQFAVIIISVVLLTHEFIALFK
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]