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The map label for this gene is tyrP [H]

Identifier: 52840892

GI number: 52840892

Start: 703073

End: 704299

Strand: Reverse

Name: tyrP [H]

Synonym: lpg0655

Alternate gene names: 52840892

Gene position: 704299-703073 (Counterclockwise)

Preceding gene: 52840893

Following gene: 52840891

Centisome position: 20.73

GC content: 41.24

Gene sequence:

>1227_bases
CTGTATTTGTACTGTTTTGGGTTATACTTCGTGATCAATTCAAAATTAATTGGTGGTATATTACTCATAGTAGGCACTTC
GATTGGTGGTGGGATGTTAGCGCTACCTGTTTCTACAGCCGAGGTGGGATTTGCTAACTCATTATTTTTCCTGTTTTTTT
GCTGGTTGGTGATGACCGCTGGAGCTTTATTAATTCTTGAGGTAAATCTACGACTCCCGGCAGGAAGCAATATGATTTCA
ATGGCGAAATCAACCTTGGGTTTGCCAGGTCAGGTAATTGCCTGGATAACCTACCTTCTTCTTCTTTATACCCTCCTGGC
GGCTTATATTTCAGGTGGAAGTGATGTATTTAGCAGTCTGCTGCATAAGGCCCACATTGATTTACCGAATTGGATAACGT
CTGTAATATTTACTGCCATGTTCAGCCTTATTGTATATAGTGGTATACGCTCTGTAGACTACGTTAATCGTGGACTTATG
TTTGGCAAACTGGGCGTCTATATTTTATTGGTTATTATTATCAGTCCCCATGTATCCACAGCAGGATTAACAGGCGGCTC
AGCGAAAGCCTTTACTGGCACTCTCATGATCTTGGTCACCTCTTTTGGATTTGCATCCATCGTGCCCAGCTTACGTGATT
ATTTTAACGATGATATACGTAGCTTACGTCGAGTTATTTTGTTTGGTTCTCTTATCCCATTATTCTGCTACATAGTCTGG
GATGCAGTGATTATGGGCGTTATCTCACGCGAGGGAGAAAATGGTTTATTGTCCCTAATGAACTCGGATCATGCAACCAG
CGGCCTCACTGAAGCACTTAGTCAATCGGTAAGCAGCCAGTGGATCAGTGGATTTTTTGGTTTTTTCACTTCGATCTGTA
TGGTTACTGCATTTCTGGGAGTTTCATTAGGATTATTTGATTTTCTTGCTGATGGATTAAAGCTTAAAAAATCTGGTAAT
CAAGGCAAGTATACACTGGCTCTCACTTTTATCCCTCCATTGGCAGTGGTGTTGTTTAACCCAGGTATCTACCTGCATGC
ATTAAGTTATGCCGGGGTTTGTTGTGTCATTTTATTGCTGTTATTACCTGCTATCATGGCATGGAAAGGAAGACAAACCT
GTAGCCAATCTCCATCAGAAACTCATTTGATTCCTGGAGGAAATCCAGCTTTAAGCCTTATAGGGTTTATCGCCATTGGT
TTGCTTATCATTGCGATCATGTATTAA

Upstream 100 bases:

>100_bases
AGGATGTATAAATTGAACGCCAGGTCATTTGCGAAAAAAAATGATTGAGGTCTACAATAAGGAAGTTGACTTTTTTTGAG
GAACAAAGTATCATTTTGTT

Downstream 100 bases:

>100_bases
TTAAAGCCTGAATATCAGCGTTAAAAAGTACAAATTTGATATATTTTAAAGTAAAGCGAAACCAGTACAAGGGCTATTTT
GTAAATCAGATAAGGAACCT

Product: tryptophan/tyrosine permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MYLYCFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNLRLPAGSNMIS
MAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLM
FGKLGVYILLVIIISPHVSTAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVW
DAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLADGLKLKKSGN
QGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIG
LLIIAIMY

Sequences:

>Translated_408_residues
MYLYCFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNLRLPAGSNMIS
MAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLM
FGKLGVYILLVIIISPHVSTAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVW
DAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLADGLKLKKSGN
QGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIG
LLIIAIMY
>Mature_408_residues
MYLYCFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNLRLPAGSNMIS
MAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLM
FGKLGVYILLVIIISPHVSTAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVW
DAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLADGLKLKKSGN
QGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIG
LLIIAIMY

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=390, Percent_Identity=35.1282051282051, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1790145, Length=395, Percent_Identity=30.6329113924051, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1789552, Length=382, Percent_Identity=27.7486910994764, Blast_Score=131, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43824; Mature: 43824

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLYCFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTA
CEEEHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCHHHHCHHHHHHHHHHHHHHHHC
GALLILEVNLRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSL
CEEEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILLVIIISPHVST
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
AGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVW
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLG
HHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLGLFDFLADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLL
HHHHHHHHHHCCCEEECCCCCCCEEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
HHHHHHHCCCCHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYLYCFGLYFVINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTA
CEEEHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCHHHHCHHHHHHHHHHHHHHHHC
GALLILEVNLRLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSL
CEEEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILLVIIISPHVST
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
AGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVW
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAVIMGVISREGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLG
HHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLGLFDFLADGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLL
HHHHHHHHHHCCCEEECCCCCCCEEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
HHHHHHHCCCCHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]