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The map label for this gene is yfnA [H]

Identifier: 52840536

GI number: 52840536

Start: 334725

End: 335909

Strand: Reverse

Name: yfnA [H]

Synonym: lpg0281

Alternate gene names: 52840536

Gene position: 335909-334725 (Counterclockwise)

Preceding gene: 52840537

Following gene: 52840535

Centisome position: 9.89

GC content: 38.82

Gene sequence:

>1185_bases
ATGCACTTAAAACGGACTTTATCATTAACACTGCTGGCCTTTTATGGGCTTGGAACTATATTGGGCGCGGGAATTTATGC
CCTTGTTGGTGAGGTCGCAAAAGAAGCGGCACAATTTACCCCTCTATCCTTCTTAATCGCCTCCATCATCGCTCTTTTTA
CTGCCATTTCTTATGCAGAATTAAGCTCCAGGTTACCGCTTAGTGCAGGCTCTGCTCTTTACGTGCGGAGGGCATTCCAT
CAAAAATGGCTATCTGGCTTAATAGGTTGGATTGTGGTTTTAACAGGTGTGATCTCGGCAGCCACCCTATCCCATGGTTT
TGTCAAATATTTTCAATTGTTTTTACCCTTACCACCTTCTCTCATCATCACTATATTAACTGTCATTTTAGCGGGAGTTG
CTGTTTGGGGTATTCGTGAATCAGCGACTCTTATCCTGTACATGACGCTCATGGAAGTGGGTGGATTATTGATGATTATT
TATTACGGTCGTTATTCATTCGCTTCTATCGACATCCAATCCTTCTCTCTTCCTCATTCTTTTGATGGGGTGCTTATTGG
AGCTTTTATTGCTTTTTATGCTTTTATTGGTTTTGAAGATATGGTTAATACAGCAGAAGAAACAATAAATCCTGAAAAAA
CTCTTCCAAAAGCTATTTTTCTTGCTTTAATATCCGCAACCATTTTATATGTTGCAGTCGCCTGGGTTATCGTTTCGACC
ATACCATCCAATGCTTTAGTCAAAACGGACATGCCCCTTATTGAAATTATTAAGCTTCAGGGACAATCCCCCTTGTTGTT
TTCAATCATTGCACTAATTTCTATTACCAATGGAATTCTGGTGCAAATTATTATGGCTTCGCGACTTATTTATGGTATGG
CTAATCAACAAAATGCCCCTCAAATATTCTCCTTTGTTTATTCCAAAACGCAAACACCAGTCAACTCGACCTTACTGGTG
TCTCTTATTATTTTACTCTTTGCCTATGCCCTCCCTATTACAACCCTGGCTAAATTAACCAGCAGTATCATATTGTGTAT
TTTTATCATCATTCATGCCTCGCTAATTAAAATCAAACTGACAAAAAAGAAACCAACAAACGCCATTTCATTCCCTATTG
TTTTCCCGATGATTTCCATTTTATTAACCCTGGCCTTTTTGATCATACAGTTTTTTTTAAAGTAG

Upstream 100 bases:

>100_bases
TTCACTATCTATTTAGTAACCGGCGAAAAATAAAAAAGTAAGCAAACAAAAAAGAAGACTTGTTCTACGACTATAGATCT
CCAGATAAAATGGGGGGGCG

Downstream 100 bases:

>100_bases
ATTATTTCTCCTAAATTTTTAACCCGGTGTCACATAAATTTTGGCAATCAACAGAATGATTGTCTGTTTTCAATTCACTG
CTCCTCTCTGCCTGTATCCC

Product: amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MHLKRTLSLTLLAFYGLGTILGAGIYALVGEVAKEAAQFTPLSFLIASIIALFTAISYAELSSRLPLSAGSALYVRRAFH
QKWLSGLIGWIVVLTGVISAATLSHGFVKYFQLFLPLPPSLIITILTVILAGVAVWGIRESATLILYMTLMEVGGLLMII
YYGRYSFASIDIQSFSLPHSFDGVLIGAFIAFYAFIGFEDMVNTAEETINPEKTLPKAIFLALISATILYVAVAWVIVST
IPSNALVKTDMPLIEIIKLQGQSPLLFSIIALISITNGILVQIIMASRLIYGMANQQNAPQIFSFVYSKTQTPVNSTLLV
SLIILLFAYALPITTLAKLTSSIILCIFIIIHASLIKIKLTKKKPTNAISFPIVFPMISILLTLAFLIIQFFLK

Sequences:

>Translated_394_residues
MHLKRTLSLTLLAFYGLGTILGAGIYALVGEVAKEAAQFTPLSFLIASIIALFTAISYAELSSRLPLSAGSALYVRRAFH
QKWLSGLIGWIVVLTGVISAATLSHGFVKYFQLFLPLPPSLIITILTVILAGVAVWGIRESATLILYMTLMEVGGLLMII
YYGRYSFASIDIQSFSLPHSFDGVLIGAFIAFYAFIGFEDMVNTAEETINPEKTLPKAIFLALISATILYVAVAWVIVST
IPSNALVKTDMPLIEIIKLQGQSPLLFSIIALISITNGILVQIIMASRLIYGMANQQNAPQIFSFVYSKTQTPVNSTLLV
SLIILLFAYALPITTLAKLTSSIILCIFIIIHASLIKIKLTKKKPTNAISFPIVFPMISILLTLAFLIIQFFLK
>Mature_394_residues
MHLKRTLSLTLLAFYGLGTILGAGIYALVGEVAKEAAQFTPLSFLIASIIALFTAISYAELSSRLPLSAGSALYVRRAFH
QKWLSGLIGWIVVLTGVISAATLSHGFVKYFQLFLPLPPSLIITILTVILAGVAVWGIRESATLILYMTLMEVGGLLMII
YYGRYSFASIDIQSFSLPHSFDGVLIGAFIAFYAFIGFEDMVNTAEETINPEKTLPKAIFLALISATILYVAVAWVIVST
IPSNALVKTDMPLIEIIKLQGQSPLLFSIIALISITNGILVQIIMASRLIYGMANQQNAPQIFSFVYSKTQTPVNSTLLV
SLIILLFAYALPITTLAKLTSSIILCIFIIIHASLIKIKLTKKKPTNAISFPIVFPMISILLTLAFLIIQFFLK

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=407, Percent_Identity=25.3071253071253, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI258614003, Length=407, Percent_Identity=25.3071253071253, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4507047, Length=414, Percent_Identity=24.6376811594203, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI258645169, Length=409, Percent_Identity=25.1833740831296, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI181337167, Length=337, Percent_Identity=28.486646884273, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI110347453, Length=345, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI114326544, Length=205, Percent_Identity=25.3658536585366, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI114326550, Length=205, Percent_Identity=25.3658536585366, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI33286428, Length=416, Percent_Identity=25.2403846153846, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786302, Length=415, Percent_Identity=24.578313253012, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786694, Length=364, Percent_Identity=25.8241758241758, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082250, Length=350, Percent_Identity=24.5714285714286, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082023, Length=348, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790653, Length=342, Percent_Identity=24.8538011695906, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789017, Length=385, Percent_Identity=21.2987012987013, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081869, Length=337, Percent_Identity=22.2551928783383, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=23.9234449760766, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=362, Percent_Identity=27.9005524861878, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17533459, Length=393, Percent_Identity=26.2086513994911, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17532491, Length=391, Percent_Identity=25.0639386189258, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540018, Length=419, Percent_Identity=23.6276849642005, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32566699, Length=314, Percent_Identity=25.4777070063694, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667468, Length=409, Percent_Identity=25.4278728606357, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24666159, Length=374, Percent_Identity=24.5989304812834, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221512776, Length=374, Percent_Identity=24.5989304812834, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24668806, Length=415, Percent_Identity=26.2650602409639, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21356285, Length=415, Percent_Identity=26.2650602409639, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24668802, Length=415, Percent_Identity=26.2650602409639, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI161077963, Length=363, Percent_Identity=26.4462809917355, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281366235, Length=378, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007820, Length=378, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007818, Length=275, Percent_Identity=28.7272727272727, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI85725152, Length=275, Percent_Identity=28.7272727272727, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550968, Length=354, Percent_Identity=26.5536723163842, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921172, Length=354, Percent_Identity=26.5536723163842, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 43021; Mature: 43021

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLKRTLSLTLLAFYGLGTILGAGIYALVGEVAKEAAQFTPLSFLIASIIALFTAISYAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LSSRLPLSAGSALYVRRAFHQKWLSGLIGWIVVLTGVISAATLSHGFVKYFQLFLPLPPS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LIITILTVILAGVAVWGIRESATLILYMTLMEVGGLLMIIYYGRYSFASIDIQSFSLPHS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCEEEEEEHHHCCCCCC
FDGVLIGAFIAFYAFIGFEDMVNTAEETINPEKTLPKAIFLALISATILYVAVAWVIVST
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPSNALVKTDMPLIEIIKLQGQSPLLFSIIALISITNGILVQIIMASRLIYGMANQQNAP
CCCCCEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
QIFSFVYSKTQTPVNSTLLVSLIILLFAYALPITTLAKLTSSIILCIFIIIHASLIKIKL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
TKKKPTNAISFPIVFPMISILLTLAFLIIQFFLK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHLKRTLSLTLLAFYGLGTILGAGIYALVGEVAKEAAQFTPLSFLIASIIALFTAISYAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LSSRLPLSAGSALYVRRAFHQKWLSGLIGWIVVLTGVISAATLSHGFVKYFQLFLPLPPS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LIITILTVILAGVAVWGIRESATLILYMTLMEVGGLLMIIYYGRYSFASIDIQSFSLPHS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCEEEEEEHHHCCCCCC
FDGVLIGAFIAFYAFIGFEDMVNTAEETINPEKTLPKAIFLALISATILYVAVAWVIVST
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPSNALVKTDMPLIEIIKLQGQSPLLFSIIALISITNGILVQIIMASRLIYGMANQQNAP
CCCCCEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
QIFSFVYSKTQTPVNSTLLVSLIILLFAYALPITTLAKLTSSIILCIFIIIHASLIKIKL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
TKKKPTNAISFPIVFPMISILLTLAFLIIQFFLK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]