| Definition | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome. |
|---|---|
| Accession | NC_002942 |
| Length | 3,397,754 |
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The map label for this gene is polI
Identifier: 52840354
GI number: 52840354
Start: 112238
End: 114928
Strand: Reverse
Name: polI
Synonym: lpg0099
Alternate gene names: 52840354
Gene position: 114928-112238 (Counterclockwise)
Preceding gene: 52840355
Following gene: 52840344
Centisome position: 3.38
GC content: 41.43
Gene sequence:
>2691_bases ATGAAACCGCCTCTGATTCTAATAGACGGATCTTCCTATTTCTTTAGAGCGTTTCATGCCCTTCCACCATTGACAAACTC CAAAGGCCAGCCTACAGGCGCCATTTATGGAGTTGCCAATATGATTAAAAAAATAATCAAAGATTATCAACCAGAAGAAA TAGCCGTTGTCTTTGATGCCAAAGGGAAAACATTCCGAGATGAATGGTATCCAGAATACAAGGCACACAGACCACCAATG CCTCAAGAATTAAGCTCTCAGTTTCAACCGCTAATCCAGTTACTGCAAGCAATGGGATTGCCCTTGCTTATCATCGATGG AGTCGAAGCAGATGATGTGATTGGCACTTTGGCAAAACAAGCCACAGAGCAAGGCATACCAGTTGTTATATCAACCGGTG ATAAAGACATGGCACAATTGGTCAATGAACATGTCTCCCTCATTAATACAATGAGTAATTACAGTATGGATATTGATGGT GTCAAAGCAAAATTTGGTGTAACACCTGAGCAAATCATTGATTACCTCACTCTCATTGGAGATAGTGTAGATAATATTCC GGGAGTAGAGAAATGCGGTCCCAAAACAGCTGTAAAATGGCTGACAGAGTATCAAACGCTTGATAATTTGCTTGCACACG CCAACGAAATTGGCGGCAAAATTGGTGAATATTTGCGTGCCAGCATCCCTCATTTGCCACTCTCAAAAAAATTGGTCACT ATCAAAACTGATTTGGATTTGCCCTTAAATTTAAACCAATTGATGCCCAAACCGGCTGATAGCGAGCAATTAATTAAATT AACTCGTGAATTAGAATTTAAGTCATGGCTTAAAGAGTTACTACAGGAAGAAGAGAATCAAAAATCACCCAAAGAAATGG ATGCCAGCAATAATAAATCCTATGAAATAATAACGACTCATAAACAGTTAAATCATTGGCTTAATAAGCTAGAGCAAAGT CAACAATTTTGCATCGACACGGAAACAACCAACCTTGATGTCATGCAAGCTGAATTGGTAGGCATCTCTTTAGCAGTTGA GGAAGAAAATGCATCTTATATTCCCCTTGCTCATACTGATGGCAGTACACAGTTAGTAAAAGAAGAAGTTTTAACTGCTT TAAAGCCTATTTTGGAAAATCCAGCTATAGGAAAAATAGGGCAAAACATTAAATATGATTACAGTGTCCTTAAAAATTAT GGCATTACCTTAAAAGGCATTGGGTACGACACCATGCTGGAATCCTATGTGCTCAATAGTGGTGCAGGCAGACATGATAT GGATTCTCTAGCTTTAAAATATCTGGGTTATAAAACAATAAGTTATGAGGATGTTGCGGGAAAGGGAGCCAAACAGCTCC GTTTTGACCAAATTCCAGTAGTGAAGGCCGGGATCTATGCAGCCGAAGACGCTGACATTACTTTGCGATTACACCATAAG CTGTACCCCATGCTGGATGAGTCATTGCGTAACGTGTTGCATGATATCGAGATACCTTTACTCACTGTTCTCGCAGACAT GGAAATGCACGGCGTTCTCATCGACCCAGTCATTCTGGAAAAGCACGGAAGTCGTTTGAAAGAACAAATGAAATCTCTGG AACAGGAAGCAGTTCAACTCGCTGGAAAAGCATTCAATCTCAATTCCCCAAAACAATTACAAGAAATACTATTTGATGAA CAAAAACTGCCTGTTGTAGCGAAAACCCCCACGGGACAGCCTTCGACCGCAGAATCTGTTTTACAGGAATTGGCTTTTGA TTATCGCCTTCCTGCTGTAATTCTGGAATACCGAAGCTTATCAAAATTGGTCAGTACCTATATTGATGCCTTACCCAAAA GAATCAACCCCAAAACACATAGAGTGCACACATCCTATAATCAAGCGGTAGCAGCAACAGGCCGATTATCTTCCAGTGAT CCTAACTTACAAAATATCCCTATACGGAGTGAAGAAGGAAGGTTGATTCGAACTGCCTTCATAGCACCAGAAGGAAGTCT TATCATGGCGGCTGATTACTCGCAAATCGAGTTAAGGATAATGGCGCATTTATCTCAAGATGATAACCTTTTACGAGCTT TTGCTAATGGCTGGGACATCCATGCCGCAACGGCGAGTGAAATCTTTCAAACGAATTTGGATGCTGTGTCCAAAGAACAA CGAAGGCGTGCCAAGGCAGTGAACTTTGGTTTGATATATGGTATGTCTGCCTTTGGACTGGCAAAACAAATTGGTGTGGA GCGTCAGGATGCTCAACATTATATTGATACTTACTTCCGCCGTTATCCTAAGGTACTTGAATACATGGAGCGTACTCGCA AACAAGCGCATCAACTTGGTTATGTTGAAACCTTGTTTGGCCGTCGTCTCTACTTGCCTGAAATTAATTCACGCAACCTA ATGAGACAAAAAGCAGCTGAGCGCACTGCCATCAACGGGCCAATGCAAGGAACCGCAGCTGACATTATAAAAAAAACCAT GCTGGCTATTTCCAGTTGGGAGCATTCGCAAAAGAACCCCTCTGCAAAGATGATCATGCAGGTACATGATGAATTGGTTT TTGAAGTCCGAAAGGAAGCGGTTGAAGAATGTCGCGCCATTATCCACAAGCTCATGGAACAAACTGTAAAATTATCTGTA CCTCTTGTTGTGTCTATTGGCACAGGTTCTAACTGGGATGATGCGCATTGA
Upstream 100 bases:
>100_bases ATCGTATCCCATTAATACGAAAAAACATTAAATCACTTACCGAGCAAGTGGCTGTAATTAACAAAAAACTTGATATTAAA GCAAAAGAGGTAGAGTAACT
Downstream 100 bases:
>100_bases AGCGCATAAAAGCGTTTAATTTATTGGATTTAATAATAATTAATAGAAGTTTGACTCGCAAAGGAAGGATTTTGACCACC TATAAACTCACCAAAATAAT
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 896; Mature: 896
Protein sequence:
>896_residues MKPPLILIDGSSYFFRAFHALPPLTNSKGQPTGAIYGVANMIKKIIKDYQPEEIAVVFDAKGKTFRDEWYPEYKAHRPPM PQELSSQFQPLIQLLQAMGLPLLIIDGVEADDVIGTLAKQATEQGIPVVISTGDKDMAQLVNEHVSLINTMSNYSMDIDG VKAKFGVTPEQIIDYLTLIGDSVDNIPGVEKCGPKTAVKWLTEYQTLDNLLAHANEIGGKIGEYLRASIPHLPLSKKLVT IKTDLDLPLNLNQLMPKPADSEQLIKLTRELEFKSWLKELLQEEENQKSPKEMDASNNKSYEIITTHKQLNHWLNKLEQS QQFCIDTETTNLDVMQAELVGISLAVEEENASYIPLAHTDGSTQLVKEEVLTALKPILENPAIGKIGQNIKYDYSVLKNY GITLKGIGYDTMLESYVLNSGAGRHDMDSLALKYLGYKTISYEDVAGKGAKQLRFDQIPVVKAGIYAAEDADITLRLHHK LYPMLDESLRNVLHDIEIPLLTVLADMEMHGVLIDPVILEKHGSRLKEQMKSLEQEAVQLAGKAFNLNSPKQLQEILFDE QKLPVVAKTPTGQPSTAESVLQELAFDYRLPAVILEYRSLSKLVSTYIDALPKRINPKTHRVHTSYNQAVAATGRLSSSD PNLQNIPIRSEEGRLIRTAFIAPEGSLIMAADYSQIELRIMAHLSQDDNLLRAFANGWDIHAATASEIFQTNLDAVSKEQ RRRAKAVNFGLIYGMSAFGLAKQIGVERQDAQHYIDTYFRRYPKVLEYMERTRKQAHQLGYVETLFGRRLYLPEINSRNL MRQKAAERTAINGPMQGTAADIIKKTMLAISSWEHSQKNPSAKMIMQVHDELVFEVRKEAVEECRAIIHKLMEQTVKLSV PLVVSIGTGSNWDDAH
Sequences:
>Translated_896_residues MKPPLILIDGSSYFFRAFHALPPLTNSKGQPTGAIYGVANMIKKIIKDYQPEEIAVVFDAKGKTFRDEWYPEYKAHRPPM PQELSSQFQPLIQLLQAMGLPLLIIDGVEADDVIGTLAKQATEQGIPVVISTGDKDMAQLVNEHVSLINTMSNYSMDIDG VKAKFGVTPEQIIDYLTLIGDSVDNIPGVEKCGPKTAVKWLTEYQTLDNLLAHANEIGGKIGEYLRASIPHLPLSKKLVT IKTDLDLPLNLNQLMPKPADSEQLIKLTRELEFKSWLKELLQEEENQKSPKEMDASNNKSYEIITTHKQLNHWLNKLEQS QQFCIDTETTNLDVMQAELVGISLAVEEENASYIPLAHTDGSTQLVKEEVLTALKPILENPAIGKIGQNIKYDYSVLKNY GITLKGIGYDTMLESYVLNSGAGRHDMDSLALKYLGYKTISYEDVAGKGAKQLRFDQIPVVKAGIYAAEDADITLRLHHK LYPMLDESLRNVLHDIEIPLLTVLADMEMHGVLIDPVILEKHGSRLKEQMKSLEQEAVQLAGKAFNLNSPKQLQEILFDE QKLPVVAKTPTGQPSTAESVLQELAFDYRLPAVILEYRSLSKLVSTYIDALPKRINPKTHRVHTSYNQAVAATGRLSSSD PNLQNIPIRSEEGRLIRTAFIAPEGSLIMAADYSQIELRIMAHLSQDDNLLRAFANGWDIHAATASEIFQTNLDAVSKEQ RRRAKAVNFGLIYGMSAFGLAKQIGVERQDAQHYIDTYFRRYPKVLEYMERTRKQAHQLGYVETLFGRRLYLPEINSRNL MRQKAAERTAINGPMQGTAADIIKKTMLAISSWEHSQKNPSAKMIMQVHDELVFEVRKEAVEECRAIIHKLMEQTVKLSV PLVVSIGTGSNWDDAH >Mature_896_residues MKPPLILIDGSSYFFRAFHALPPLTNSKGQPTGAIYGVANMIKKIIKDYQPEEIAVVFDAKGKTFRDEWYPEYKAHRPPM PQELSSQFQPLIQLLQAMGLPLLIIDGVEADDVIGTLAKQATEQGIPVVISTGDKDMAQLVNEHVSLINTMSNYSMDIDG VKAKFGVTPEQIIDYLTLIGDSVDNIPGVEKCGPKTAVKWLTEYQTLDNLLAHANEIGGKIGEYLRASIPHLPLSKKLVT IKTDLDLPLNLNQLMPKPADSEQLIKLTRELEFKSWLKELLQEEENQKSPKEMDASNNKSYEIITTHKQLNHWLNKLEQS QQFCIDTETTNLDVMQAELVGISLAVEEENASYIPLAHTDGSTQLVKEEVLTALKPILENPAIGKIGQNIKYDYSVLKNY GITLKGIGYDTMLESYVLNSGAGRHDMDSLALKYLGYKTISYEDVAGKGAKQLRFDQIPVVKAGIYAAEDADITLRLHHK LYPMLDESLRNVLHDIEIPLLTVLADMEMHGVLIDPVILEKHGSRLKEQMKSLEQEAVQLAGKAFNLNSPKQLQEILFDE QKLPVVAKTPTGQPSTAESVLQELAFDYRLPAVILEYRSLSKLVSTYIDALPKRINPKTHRVHTSYNQAVAATGRLSSSD PNLQNIPIRSEEGRLIRTAFIAPEGSLIMAADYSQIELRIMAHLSQDDNLLRAFANGWDIHAATASEIFQTNLDAVSKEQ RRRAKAVNFGLIYGMSAFGLAKQIGVERQDAQHYIDTYFRRYPKVLEYMERTRKQAHQLGYVETLFGRRLYLPEINSRNL MRQKAAERTAINGPMQGTAADIIKKTMLAISSWEHSQKNPSAKMIMQVHDELVFEVRKEAVEECRAIIHKLMEQTVKLSV PLVVSIGTGSNWDDAH
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=518, Percent_Identity=31.0810810810811, Blast_Score=246, Evalue=6e-65, Organism=Homo sapiens, GI139394648, Length=519, Percent_Identity=29.2870905587669, Blast_Score=206, Evalue=6e-53, Organism=Escherichia coli, GI1790294, Length=922, Percent_Identity=55.3145336225597, Blast_Score=982, Evalue=0.0, Organism=Escherichia coli, GI226510970, Length=252, Percent_Identity=29.7619047619048, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI86563272, Length=395, Percent_Identity=29.3670886075949, Blast_Score=164, Evalue=3e-40, Organism=Drosophila melanogaster, GI17933644, Length=469, Percent_Identity=30.2771855010661, Blast_Score=195, Evalue=1e-49,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01612 3_5_exonuc; PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 100504; Mature: 100504
Theoretical pI: Translated: 6.25; Mature: 6.25
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKPPLILIDGSSYFFRAFHALPPLTNSKGQPTGAIYGVANMIKKIIKDYQPEEIAVVFDA CCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEC KGKTFRDEWYPEYKAHRPPMPQELSSQFQPLIQLLQAMGLPLLIIDGVEADDVIGTLAKQ CCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHH ATEQGIPVVISTGDKDMAQLVNEHVSLINTMSNYSMDIDGVKAKFGVTPEQIIDYLTLIG HHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHC DSVDNIPGVEKCGPKTAVKWLTEYQTLDNLLAHANEIGGKIGEYLRASIPHLPLSKKLVT CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE IKTDLDLPLNLNQLMPKPADSEQLIKLTRELEFKSWLKELLQEEENQKSPKEMDASNNKS EEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC YEIITTHKQLNHWLNKLEQSQQFCIDTETTNLDVMQAELVGISLAVEEENASYIPLAHTD EEEEECHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHEEEEEEEECCCCCEEEEEECC GSTQLVKEEVLTALKPILENPAIGKIGQNIKYDYSVLKNYGITLKGIGYDTMLESYVLNS CCHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHCC GAGRHDMDSLALKYLGYKTISYEDVAGKGAKQLRFDQIPVVKAGIYAAEDADITLRLHHK CCCCCHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCCEEECCEEEECCCCEEEEEHHH LYPMLDESLRNVLHDIEIPLLTVLADMEMHGVLIDPVILEKHGSRLKEQMKSLEQEAVQL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHH AGKAFNLNSPKQLQEILFDEQKLPVVAKTPTGQPSTAESVLQELAFDYRLPAVILEYRSL HCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH SKLVSTYIDALPKRINPKTHRVHTSYNQAVAATGRLSSSDPNLQNIPIRSEEGRLIRTAF HHHHHHHHHHHHHHCCCCHHEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEE IAPEGSLIMAADYSQIELRIMAHLSQDDNLLRAFANGWDIHAATASEIFQTNLDAVSKEQ ECCCCCEEEEECCCHHEEHHHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH RRRAKAVNFGLIYGMSAFGLAKQIGVERQDAQHYIDTYFRRYPKVLEYMERTRKQAHQLG HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC YVETLFGRRLYLPEINSRNLMRQKAAERTAINGPMQGTAADIIKKTMLAISSWEHSQKNP HHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC SAKMIMQVHDELVFEVRKEAVEECRAIIHKLMEQTVKLSVPLVVSIGTGSNWDDAH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC >Mature Secondary Structure MKPPLILIDGSSYFFRAFHALPPLTNSKGQPTGAIYGVANMIKKIIKDYQPEEIAVVFDA CCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEC KGKTFRDEWYPEYKAHRPPMPQELSSQFQPLIQLLQAMGLPLLIIDGVEADDVIGTLAKQ CCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHH ATEQGIPVVISTGDKDMAQLVNEHVSLINTMSNYSMDIDGVKAKFGVTPEQIIDYLTLIG HHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHC DSVDNIPGVEKCGPKTAVKWLTEYQTLDNLLAHANEIGGKIGEYLRASIPHLPLSKKLVT CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE IKTDLDLPLNLNQLMPKPADSEQLIKLTRELEFKSWLKELLQEEENQKSPKEMDASNNKS EEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC YEIITTHKQLNHWLNKLEQSQQFCIDTETTNLDVMQAELVGISLAVEEENASYIPLAHTD EEEEECHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHEEEEEEEECCCCCEEEEEECC GSTQLVKEEVLTALKPILENPAIGKIGQNIKYDYSVLKNYGITLKGIGYDTMLESYVLNS CCHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHCC GAGRHDMDSLALKYLGYKTISYEDVAGKGAKQLRFDQIPVVKAGIYAAEDADITLRLHHK CCCCCHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCCEEECCEEEECCCCEEEEEHHH LYPMLDESLRNVLHDIEIPLLTVLADMEMHGVLIDPVILEKHGSRLKEQMKSLEQEAVQL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHH AGKAFNLNSPKQLQEILFDEQKLPVVAKTPTGQPSTAESVLQELAFDYRLPAVILEYRSL HCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH SKLVSTYIDALPKRINPKTHRVHTSYNQAVAATGRLSSSDPNLQNIPIRSEEGRLIRTAF HHHHHHHHHHHHHHCCCCHHEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEE IAPEGSLIMAADYSQIELRIMAHLSQDDNLLRAFANGWDIHAATASEIFQTNLDAVSKEQ ECCCCCEEEEECCCHHEEHHHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH RRRAKAVNFGLIYGMSAFGLAKQIGVERQDAQHYIDTYFRRYPKVLEYMERTRKQAHQLG HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC YVETLFGRRLYLPEINSRNLMRQKAAERTAINGPMQGTAADIIKKTMLAISSWEHSQKNP HHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC SAKMIMQVHDELVFEVRKEAVEECRAIIHKLMEQTVKLSVPLVVSIGTGSNWDDAH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10984043 [H]