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The map label for this gene is yoaD [H]

Identifier: 52787739

GI number: 52787739

Start: 3885913

End: 3886533

Strand: Reverse

Name: yoaD [H]

Synonym: BLi04062

Alternate gene names: 52787739

Gene position: 3886533-3885913 (Counterclockwise)

Preceding gene: 52787740

Following gene: 52787737

Centisome position: 92.04

GC content: 51.05

Gene sequence:

>621_bases
TTGGCATTCGGTCTTCTGCTGTCTGGCGCCCGTTCGATCCCGCAGTCAAACGCGGCAGTCAAAGCGGGCTTATGGCAAGC
GGCGATGGGCTATGAGCTCGATGGAAAAACGCTGGGGCTTATCGGTTTTGGGGAAATCGGCAAAAAGGTTGCAAGGCGGG
CTGCCGGGTTTAATATGAACGTTTTGGCGTACGGCACATACAAAGACTACAATGCAGCCAAACGGCTGAATGTGAGGTTC
GCCGAGCTTGACGATCTCCTGGAAAAATCGGACTTTGTATGTATCAGCACATCATTGAGACCTGCCACCTATCATTTAAT
CAATCAAGAAAAACTGGCAAAAATGAAGAAAACCGCGTACCTGATCAACATTGCCCGCGGAGAAGTGGTGGACGAAAGCG
CGCTTATTCAAGCGCTTGAGCAAAAACAGATCAGAGGCGCAGCATTGGACGTCTTTGAAACCGAACCGCCGGCTGCCCGG
ATCGCCGGTCTCAGCAATGTCATTTGCACGGCGCATATCGGCGGCGCTACGTATGAGAGCATCAGGCGCATCGAAGAGAT
GACATATCAAAACATCAAAAGGTTTATCGAAAAACAGCAGCCGGCTTTCCGCGTTCAATAA

Upstream 100 bases:

>100_bases
ATTCGGCGCGGGAATCGACAATATTGATGTGGAATATGCAAACGAAAAAGGGATTCTCGTCACGAATGCACCCGGCTAAA
ATGCCTCGGCGGTCGCCGAT

Downstream 100 bases:

>100_bases
AAACCGGAAACGGCGATAAGCCGCGTCCGGTTATGTTCTTTGAAAAAACTCGACCATTTCTCCTTCGGGCCCAAAAAGAA
AAAAATAGCGGAAGCCGTTC

Product: YoaD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MAFGLLLSGARSIPQSNAAVKAGLWQAAMGYELDGKTLGLIGFGEIGKKVARRAAGFNMNVLAYGTYKDYNAAKRLNVRF
AELDDLLEKSDFVCISTSLRPATYHLINQEKLAKMKKTAYLINIARGEVVDESALIQALEQKQIRGAALDVFETEPPAAR
IAGLSNVICTAHIGGATYESIRRIEEMTYQNIKRFIEKQQPAFRVQ

Sequences:

>Translated_206_residues
MAFGLLLSGARSIPQSNAAVKAGLWQAAMGYELDGKTLGLIGFGEIGKKVARRAAGFNMNVLAYGTYKDYNAAKRLNVRF
AELDDLLEKSDFVCISTSLRPATYHLINQEKLAKMKKTAYLINIARGEVVDESALIQALEQKQIRGAALDVFETEPPAAR
IAGLSNVICTAHIGGATYESIRRIEEMTYQNIKRFIEKQQPAFRVQ
>Mature_205_residues
AFGLLLSGARSIPQSNAAVKAGLWQAAMGYELDGKTLGLIGFGEIGKKVARRAAGFNMNVLAYGTYKDYNAAKRLNVRFA
ELDDLLEKSDFVCISTSLRPATYHLINQEKLAKMKKTAYLINIARGEVVDESALIQALEQKQIRGAALDVFETEPPAARI
AGLSNVICTAHIGGATYESIRRIEEMTYQNIKRFIEKQQPAFRVQ

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=194, Percent_Identity=39.1752577319588, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI4557497, Length=171, Percent_Identity=39.766081871345, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI61743967, Length=171, Percent_Identity=39.766081871345, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI145580575, Length=179, Percent_Identity=39.1061452513966, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI145580578, Length=171, Percent_Identity=40.3508771929825, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI4557499, Length=171, Percent_Identity=40.3508771929825, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI6912396, Length=200, Percent_Identity=35.5, Blast_Score=115, Evalue=3e-26,
Organism=Escherichia coli, GI87082289, Length=186, Percent_Identity=44.0860215053763, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1789279, Length=182, Percent_Identity=36.2637362637363, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787645, Length=208, Percent_Identity=29.3269230769231, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081824, Length=156, Percent_Identity=31.4102564102564, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788660, Length=126, Percent_Identity=34.1269841269841, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=194, Percent_Identity=36.5979381443299, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=172, Percent_Identity=26.7441860465116, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=200, Percent_Identity=32.5, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=198, Percent_Identity=35.8585858585859, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=197, Percent_Identity=36.0406091370558, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324980, Length=175, Percent_Identity=28, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=176, Percent_Identity=26.7045454545455, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=204, Percent_Identity=28.4313725490196, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=186, Percent_Identity=33.8709677419355, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45552429, Length=203, Percent_Identity=32.0197044334975, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551003, Length=203, Percent_Identity=32.0197044334975, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574284, Length=203, Percent_Identity=32.0197044334975, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585514, Length=203, Percent_Identity=32.0197044334975, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574282, Length=203, Percent_Identity=32.0197044334975, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472511, Length=181, Percent_Identity=39.7790055248619, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646446, Length=171, Percent_Identity=40.3508771929825, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646448, Length=171, Percent_Identity=40.3508771929825, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646452, Length=171, Percent_Identity=40.3508771929825, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646450, Length=171, Percent_Identity=40.3508771929825, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574286, Length=186, Percent_Identity=32.7956989247312, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571528, Length=174, Percent_Identity=36.2068965517241, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585516, Length=213, Percent_Identity=25.3521126760563, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 22718; Mature: 22586

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGLLLSGARSIPQSNAAVKAGLWQAAMGYELDGKTLGLIGFGEIGKKVARRAAGFNMN
CCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEECCCCEEEEEECHHHHHHHHHHHCCCCCE
VLAYGTYKDYNAAKRLNVRFAELDDLLEKSDFVCISTSLRPATYHLINQEKLAKMKKTAY
EEEEECCCCCCHHHHHCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHCHHHHHHHHHHHH
LINIARGEVVDESALIQALEQKQIRGAALDVFETEPPAARIAGLSNVICTAHIGGATYES
EEEECCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHEEEEECCCHHHHH
IRRIEEMTYQNIKRFIEKQQPAFRVQ
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AFGLLLSGARSIPQSNAAVKAGLWQAAMGYELDGKTLGLIGFGEIGKKVARRAAGFNMN
CCHHHHHHHHCCCCCCCHHHHHHHHHHCCEECCCCEEEEEECHHHHHHHHHHHCCCCCE
VLAYGTYKDYNAAKRLNVRFAELDDLLEKSDFVCISTSLRPATYHLINQEKLAKMKKTAY
EEEEECCCCCCHHHHHCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHCHHHHHHHHHHHH
LINIARGEVVDESALIQALEQKQIRGAALDVFETEPPAARIAGLSNVICTAHIGGATYES
EEEECCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHEEEEECCCHHHHH
IRRIEEMTYQNIKRFIEKQQPAFRVQ
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA