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The map label for this gene is glyA [H]

Identifier: 52787613

GI number: 52787613

Start: 3760095

End: 3761342

Strand: Reverse

Name: glyA [H]

Synonym: BLi03935

Alternate gene names: 52787613

Gene position: 3761342-3760095 (Counterclockwise)

Preceding gene: 52787614

Following gene: 52787612

Centisome position: 89.08

GC content: 49.52

Gene sequence:

>1248_bases
ATGAAACATTTACCTGCGCAAGATGAACAAGTTTTTAGCGCCATTCAAGATGAGCGGAAACGTCAACAGTCGAAGATTGA
GCTGATCGCTTCTGAAAACTTTGTAAGCGAAGCGGTTATGGAAGCTCAAGGCTCGGTTTTAACTAATAAATATGCGGAAG
GATATCCTGGTAAACGCTACTACGGCGGTTGTGAGCATGTAGACGTGGCAGAGGATATCGCGCGCGACCGCGCCAAGCAG
ATTTTCGGCGCCGAGCACGTCAACGTTCAGCCGCATTCCGGCGCACAAGCGAACATGGCGGTATACTTCACGATTTTGGA
GCACGGTGACACTGTGTTGGGAATGAACCTTGCTCACGGCGGACATTTAACGCACGGCAGCCCTGTCAACTTCAGCGGTG
TTCAGTACAACTTCGTTGAATACGGCGTTGATAAAGAGACGCAGTATATTGATTACGAAGATGTCCGTGAAAAGGCGCTC
AAACATAAGCCTAAGCTGATCGTGGCCGGAGCAAGCGCATATCCGCGCACCATCGATTTTAAAAAGTTCCGCGAAATCGC
TGATGAAGTCGGAGCCTATGTGATGGTGGACATGGCGCATATCGCCGGACTTGTAGCAGCAGGTCTTCACCCGAATCCTG
TTCCTTACGCTGACTTTGTGACGACGACAACTCATAAAACGCTTCGCGGACCGCGCGGCGGCATGATTCTTTGCCGTGAA
GAGTTTGCGAAACAAATTGACAAGTCGATCTTCCCTGGAATTCAAGGCGGACCGTTAATGCACGTGATCGCTGCAAAGGC
TGTTTCCTTTGGCGAAGCTTTAAAGGACGAATTCAAAACATATGCCCAAAATGTCATCAACAATGCGAAGCGCTTGGCTG
AAACATTGAAAAAAGAGGGTATCGAGCTCGTATCCGGCGGAACGGATAACCATCTTGTGCTGGTCGACCTGCGCTCTCTC
GGCATTACCGGAAAAGTGGCTGAAAATGTACTTGATGAAGTCGGCATCACCGTCAACAAAAACGCGATTCCTTATGATCC
TGAAAAACCTTTCGTTACGAGCGGAATCCGCGTCGGTACAGCAGCTGTGACGAGCCGCGGCTTTGATCTGGAAGCGATCG
AAGAAGTGGGAGCGATCATTGCGCTTGCCCTTAAAAACCATGAAGACGAAGCGAAACTTGAAGAAGCAAAACAGCGTGTA
GAAGCGCTGACAAACAGATTCCCGTTGTATACCGGGCTTGATTACTAA

Upstream 100 bases:

>100_bases
AACGAATTTTAAAAATAATCTCTTACATTTGCATGAAAAACCGTGTACAATGAGATGGTATAATTAACGAAATGGAAACA
GATAGGAGAGGATCTCGCTG

Downstream 100 bases:

>100_bases
GATATTTGCGCCGCTCCGAAAAGGGGCGGCTTTTTTCATAAAATTGTCTCCTGATTTTTGTTGAAACAAGCTGTTTTTTT
ATGTAGAATCAATAGAAGTG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKHLPAQDEQVFSAIQDERKRQQSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVAEDIARDRAKQ
IFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLAHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYEDVREKAL
KHKPKLIVAGASAYPRTIDFKKFREIADEVGAYVMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
EFAKQIDKSIFPGIQGGPLMHVIAAKAVSFGEALKDEFKTYAQNVINNAKRLAETLKKEGIELVSGGTDNHLVLVDLRSL
GITGKVAENVLDEVGITVNKNAIPYDPEKPFVTSGIRVGTAAVTSRGFDLEAIEEVGAIIALALKNHEDEAKLEEAKQRV
EALTNRFPLYTGLDY

Sequences:

>Translated_415_residues
MKHLPAQDEQVFSAIQDERKRQQSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVAEDIARDRAKQ
IFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLAHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYEDVREKAL
KHKPKLIVAGASAYPRTIDFKKFREIADEVGAYVMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
EFAKQIDKSIFPGIQGGPLMHVIAAKAVSFGEALKDEFKTYAQNVINNAKRLAETLKKEGIELVSGGTDNHLVLVDLRSL
GITGKVAENVLDEVGITVNKNAIPYDPEKPFVTSGIRVGTAAVTSRGFDLEAIEEVGAIIALALKNHEDEAKLEEAKQRV
EALTNRFPLYTGLDY
>Mature_415_residues
MKHLPAQDEQVFSAIQDERKRQQSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVAEDIARDRAKQ
IFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLAHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYEDVREKAL
KHKPKLIVAGASAYPRTIDFKKFREIADEVGAYVMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
EFAKQIDKSIFPGIQGGPLMHVIAAKAVSFGEALKDEFKTYAQNVINNAKRLAETLKKEGIELVSGGTDNHLVLVDLRSL
GITGKVAENVLDEVGITVNKNAIPYDPEKPFVTSGIRVGTAAVTSRGFDLEAIEEVGAIIALALKNHEDEAKLEEAKQRV
EALTNRFPLYTGLDY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=451, Percent_Identity=42.1286031042129, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862352, Length=451, Percent_Identity=42.1286031042129, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862350, Length=451, Percent_Identity=42.1286031042129, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862348, Length=451, Percent_Identity=42.1286031042129, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862346, Length=447, Percent_Identity=41.6107382550336, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI22547186, Length=453, Percent_Identity=42.6048565121413, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI22547189, Length=438, Percent_Identity=41.7808219178082, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1788902, Length=407, Percent_Identity=59.4594594594595, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI25144732, Length=401, Percent_Identity=47.3815461346633, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=47.3815461346633, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=45.985401459854, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=431, Percent_Identity=43.8515081206497, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI24640005, Length=448, Percent_Identity=43.0803571428571, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=448, Percent_Identity=43.0803571428571, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45510; Mature: 45510

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLPAQDEQVFSAIQDERKRQQSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVAEDIARDRAKQIFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLAHG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYEDVREKALKHKPKLIVAGASAYPRTIDF
CCCCCCCCCCCCCEEEEHHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGAYVMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
HHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHCCCCCCEEEEHH
EFAKQIDKSIFPGIQGGPLMHVIAAKAVSFGEALKDEFKTYAQNVINNAKRLAETLKKEG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IELVSGGTDNHLVLVDLRSLGITGKVAENVLDEVGITVNKNAIPYDPEKPFVTSGIRVGT
CEEECCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEECH
AAVTSRGFDLEAIEEVGAIIALALKNHEDEAKLEEAKQRVEALTNRFPLYTGLDY
HHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKHLPAQDEQVFSAIQDERKRQQSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVAEDIARDRAKQIFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLAHG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYEDVREKALKHKPKLIVAGASAYPRTIDF
CCCCCCCCCCCCCEEEEHHEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCH
KKFREIADEVGAYVMVDMAHIAGLVAAGLHPNPVPYADFVTTTTHKTLRGPRGGMILCRE
HHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHCCCCCCEEEEHH
EFAKQIDKSIFPGIQGGPLMHVIAAKAVSFGEALKDEFKTYAQNVINNAKRLAETLKKEG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IELVSGGTDNHLVLVDLRSLGITGKVAENVLDEVGITVNKNAIPYDPEKPFVTSGIRVGT
CEEECCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEECH
AAVTSRGFDLEAIEEVGAIIALALKNHEDEAKLEEAKQRVEALTNRFPLYTGLDY
HHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA