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The map label for this gene is upp

Identifier: 52787612

GI number: 52787612

Start: 3759339

End: 3759968

Strand: Reverse

Name: upp

Synonym: BLi03934

Alternate gene names: 52787612

Gene position: 3759968-3759339 (Counterclockwise)

Preceding gene: 52787613

Following gene: 52787611

Centisome position: 89.04

GC content: 48.1

Gene sequence:

>630_bases
ATGGGAAAGGTATATGTGTTTGATCACCCTCTTATACAGCATAAGCTTACATACATCCGGGACGTAAAGACCGGAACGAA
AGAATTCAGAGAGCTTGTTGATGAGGTTGCAACGCTGATGGCATTTGAGATTACGCGAGACCTGCCGCTGGAGGAAGTGA
ATGTAGAGACTCCTGTGCAAATGGCAAAGTCAAACGTCATCGCCGGAAAAAAACTCGGGGTTGTTCCGATTCTGAGAGCA
GGGCTTGGAATGGTAGACGGAATTTTGAAGCTGATTCCTGCTGCAAAAGTCGGACATGTCGGGCTTTACCGTGATCCTGA
AACATTGAAGCCTGTTGAGTATTATGTCAAGCTTCCATCCGATGTTGAAGAACGCGAATTCATCGTCGTCGATCCGATGC
TGGCAACCGGAGGTTCGGCGGTAGAGGCGCTGAACAGCTTGAAAAAACGCGGCGCAAAAAATATCCGCTTTATGTGTCTG
ATCGCTGCCCCGGAAGGTGTAGACGAAGTGCAGAAGCATCATCCTGACGTTGACATTTACATTGCCGCTCTGGATGAAAA
ACTAAATGAAAAAGGATATATCGTTCCCGGATTGGGCGACGCCGGAGACCGCATGTTCGGAACGAAATAA

Upstream 100 bases:

>100_bases
CGGCTTTTTTCATAAAATTGTCTCCTGATTTTTGTTGAAACAAGCTGTTTTTTTATGTAGAATCAATAGAAGTGTGTGAA
AAAAGGAGCTGAAGACGGAT

Downstream 100 bases:

>100_bases
TGTAAGAAAATCCTGAAAAAGGGTTTTCTTTTTTTGTGTTTTATACCATAATTAAACATGTGTGCGTCTTAAATGAGGCG
AATTTGTGAACATTTTGTGA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGKVYVFDHPLIQHKLTYIRDVKTGTKEFRELVDEVATLMAFEITRDLPLEEVNVETPVQMAKSNVIAGKKLGVVPILRA
GLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEALNSLKKRGAKNIRFMCL
IAAPEGVDEVQKHHPDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK

Sequences:

>Translated_209_residues
MGKVYVFDHPLIQHKLTYIRDVKTGTKEFRELVDEVATLMAFEITRDLPLEEVNVETPVQMAKSNVIAGKKLGVVPILRA
GLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEALNSLKKRGAKNIRFMCL
IAAPEGVDEVQKHHPDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK
>Mature_208_residues
GKVYVFDHPLIQHKLTYIRDVKTGTKEFRELVDEVATLMAFEITRDLPLEEVNVETPVQMAKSNVIAGKKLGVVPILRAG
LGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEALNSLKKRGAKNIRFMCLI
AAPEGVDEVQKHHPDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.1980198019802, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.1980198019802, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=51.207729468599, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=24.8780487804878, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=24.8780487804878, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.0625, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=30.5418719211823, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=30.5418719211823, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_BACLD (Q65DW6)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_081011.1
- RefSeq:   YP_093441.1
- HSSP:   P70881
- ProteinModelPortal:   Q65DW6
- SMR:   Q65DW6
- STRING:   Q65DW6
- EnsemblBacteria:   EBBACT00000054357
- EnsemblBacteria:   EBBACT00000058573
- GeneID:   3028298
- GeneID:   3101272
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03934
- KEGG:   bli:BL03992
- NMPDR:   fig|279010.5.peg.4072
- eggNOG:   COG0035
- GeneTree:   EBGT00050000001265
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   BLIC279010-1:BLI03934-MONOMER
- BioCyc:   BLIC279010:BL03992-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23039; Mature: 22908

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYVFDHPLIQHKLTYIRDVKTGTKEFRELVDEVATLMAFEITRDLPLEEVNVETPVQ
CCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHH
MAKSNVIAGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPS
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEECCC
DVEEREFIVVDPMLATGGSAVEALNSLKKRGAKNIRFMCLIAAPEGVDEVQKHHPDVDIY
CCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCEEEE
IAALDEKLNEKGYIVPGLGDAGDRMFGTK
EEEECHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKVYVFDHPLIQHKLTYIRDVKTGTKEFRELVDEVATLMAFEITRDLPLEEVNVETPVQ
CEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHH
MAKSNVIAGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPS
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEECCC
DVEEREFIVVDPMLATGGSAVEALNSLKKRGAKNIRFMCLIAAPEGVDEVQKHHPDVDIY
CCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHCCCEEEE
IAALDEKLNEKGYIVPGLGDAGDRMFGTK
EEEECHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA