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The map label for this gene is clpP2

Identifier: 52787568

GI number: 52787568

Start: 3711337

End: 3711909

Strand: Reverse

Name: clpP2

Synonym: BLi03890

Alternate gene names: 52787568

Gene position: 3711909-3711337 (Counterclockwise)

Preceding gene: 52787569

Following gene: 52787564

Centisome position: 87.9

GC content: 47.99

Gene sequence:

>573_bases
ATGAACACCATTCCTTACGTCATTGAGAAAACGGCTGCCGGTGAAAGATCGTACGATATTTTTTCCAGACTTTTAAAAGA
CCGGATCATTATGATCGGTTCTGAATTCAACGATGACCTCGCCAATCGGGTCACCGCCCAATTGCTGTTTTTGTCAGCTG
AAGACAATGAAAAAGACATTTCGATCTATATCAACAGCCCGGGCGGATCAACTTCCGCGGGATATGCAATTTTGGATACG
ATGGATTATGTGAAGCCTGATGTCCGCACGATATGCGTCGGAATGGCCGCTTCCATGGGAGCGATTCTCCTCGCCGGCGG
AGCAAAAGGCAAACGGTATGCACTCAAAAACAGCGAAATCATGATCCATCAGCCGCTCGGCGGCGTCAAAGGACAGGCGA
CAGACATGGAGATTTCAGCGAAGCGGATCATCAAACTGAGGGAAAAAATCGAGCGCTTCTTTCACGAACGAACGGGCCAG
CCCATTGAAAAACTAAAAGCCGACATGGAACGCGATTACTTTATGGATGCGGACGAAGCGAAGGCATACGGTGTTATTGA
TGCTGTTTTGTAA

Upstream 100 bases:

>100_bases
GATGATCTGCTCGAATTTGCCAAACAGACATGGCGTTTCGACGCTTCACAGCCGTCTTGCATCAGCATGATGAGGTGCGC
TGCCTAGGAGGAAAAATGCT

Downstream 100 bases:

>100_bases
CATTAGAAAAGCTCCCGGCTTAACTCCAGCCGGGAGCTTCGATCTTTTTTATAAAGCGTCAGGACCTTCCTCGCCTGTGC
GGATGTTGATGGTGTTTTTA

Product: hypothetical protein

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MNTIPYVIEKTAAGERSYDIFSRLLKDRIIMIGSEFNDDLANRVTAQLLFLSAEDNEKDISIYINSPGGSTSAGYAILDT
MDYVKPDVRTICVGMAASMGAILLAGGAKGKRYALKNSEIMIHQPLGGVKGQATDMEISAKRIIKLREKIERFFHERTGQ
PIEKLKADMERDYFMDADEAKAYGVIDAVL

Sequences:

>Translated_190_residues
MNTIPYVIEKTAAGERSYDIFSRLLKDRIIMIGSEFNDDLANRVTAQLLFLSAEDNEKDISIYINSPGGSTSAGYAILDT
MDYVKPDVRTICVGMAASMGAILLAGGAKGKRYALKNSEIMIHQPLGGVKGQATDMEISAKRIIKLREKIERFFHERTGQ
PIEKLKADMERDYFMDADEAKAYGVIDAVL
>Mature_190_residues
MNTIPYVIEKTAAGERSYDIFSRLLKDRIIMIGSEFNDDLANRVTAQLLFLSAEDNEKDISIYINSPGGSTSAGYAILDT
MDYVKPDVRTICVGMAASMGAILLAGGAKGKRYALKNSEIMIHQPLGGVKGQATDMEISAKRIIKLREKIERFFHERTGQ
PIEKLKADMERDYFMDADEAKAYGVIDAVL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=49.4736842105263, Blast_Score=204, Evalue=3e-53,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=55.2631578947368, Blast_Score=231, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=44.6236559139785, Blast_Score=180, Evalue=4e-46,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=53.6842105263158, Blast_Score=217, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_BACLD (Q65E10)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080968.1
- RefSeq:   YP_093397.1
- ProteinModelPortal:   Q65E10
- SMR:   Q65E10
- STRING:   Q65E10
- MEROPS:   S14.001
- EnsemblBacteria:   EBBACT00000057777
- EnsemblBacteria:   EBBACT00000058715
- GeneID:   3028091
- GeneID:   3101125
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03890
- KEGG:   bli:BL05355
- NMPDR:   fig|279010.5.peg.4133
- eggNOG:   COG0740
- GeneTree:   EBGT00050000002046
- HOGENOM:   HBG558421
- OMA:   NARIMTH
- ProtClustDB:   CLSK737604
- BioCyc:   BLIC279010-1:BLI03890-MONOMER
- BioCyc:   BLIC279010:BL05355-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21050; Mature: 21050

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIPYVIEKTAAGERSYDIFSRLLKDRIIMIGSEFNDDLANRVTAQLLFLSAEDNEKDI
CCCCCCEEECCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHEEEECCCCCCEE
SIYINSPGGSTSAGYAILDTMDYVKPDVRTICVGMAASMGAILLAGGAKGKRYALKNSEI
EEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCCEEEECCCEE
MIHQPLGGVKGQATDMEISAKRIIKLREKIERFFHERTGQPIEKLKADMERDYFMDADEA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
KAYGVIDAVL
HHHHHHHHCC
>Mature Secondary Structure
MNTIPYVIEKTAAGERSYDIFSRLLKDRIIMIGSEFNDDLANRVTAQLLFLSAEDNEKDI
CCCCCCEEECCCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHEEEECCCCCCEE
SIYINSPGGSTSAGYAILDTMDYVKPDVRTICVGMAASMGAILLAGGAKGKRYALKNSEI
EEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCCEEEECCCEE
MIHQPLGGVKGQATDMEISAKRIIKLREKIERFFHERTGQPIEKLKADMERDYFMDADEA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
KAYGVIDAVL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA