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The map label for this gene is alsR [H]

Identifier: 52787528

GI number: 52787528

Start: 3677021

End: 3677899

Strand: Direct

Name: alsR [H]

Synonym: BLi03849

Alternate gene names: 52787528

Gene position: 3677021-3677899 (Clockwise)

Preceding gene: 52787525

Following gene: 52787530

Centisome position: 87.08

GC content: 50.17

Gene sequence:

>879_bases
ATGGAGCTGCGCCATCTTCGTTATTTTATGGTTGTTGCCGAAGAACTGCATTTCGGAAAAGCAGCTCTTCGGCTGAACAT
GACTCAGCCTCCGCTCAGCCAGCAGATTAAACAGCTAGAAAGTGAAATAGGCGTCACCTTGCTGAAGAGGTCAAAAAGAG
CCGTCAGGCTAACGGCGGCAGGCGGGGTCTTTTTAAAACAAATCAAGGAAGGACTTTCCCAGATTGATCAGGCCGTCGAC
ATGGCTCAGCGGACGGCCCGCGGGGAGCTGGGAAGACTCGTGATCGGCTTTGTCGGCTCCGCAACATACGAGATCATGCC
TCCCATCATCAGGGAATACCGAAACCGGTTCCCGTCCGTGCAGATCGATCTTCGGGAGCTTTCAACCCCCAATCAGATCG
ATGCACTGCTAAACGGGCATATTGACATCGGGGTGCTGCATCCCCCGTTGGGAAACGACGAACTGAAGTCATACACGGTA
AAAAAAAGCCATTGTGTCCTTGCACTTCCAAAACACCACCCGTTGACAGAAAAAGCCCGGGTACATTTGAAGGATCTTGA
AGAAGAATCGCTGATCGTCATTGCCAAAGAAGCGTGGCCCTCTTTATACACGGAATTCAATTTCTTGTGTGAAAAAGCCG
GATTTATCCCCAACATCGCCCAGGAAGCTACAGAATACCAAATGGTGATCGGCCTCGTATCGGCCGGAATGGGAATCGCC
GTCGTGCCTACGGCGGCTAAACGATTATTTAACCTTGATGTTGTATACAAAGAAATCGAAGACTTTCCCCTTCGCGCCGA
ATGGATTACCGCACATCGAAAGGACAACCGCAATCCGGCACTTAAGCATTTCATCGAAATCTCAGATCAACACTCATAG

Upstream 100 bases:

>100_bases
TTAAATATACATCTTGTGGAAATTGTTTTCCAATACTTCTTTGTCTTACAATTAATATGTAAAACGACTGAAATCGCATT
CAGAAAGGAATGAGTGATTA

Downstream 100 bases:

>100_bases
CCGTATAGAAAAAACCCCGTGGACAAATCCTCCTTGTTCACGGGGTTTTTTCCTCATATAGACGTTTGCAAGTTTTGAAA
ACGCAGTTAAATGCCGATTG

Product: AlsR

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MELRHLRYFMVVAEELHFGKAALRLNMTQPPLSQQIKQLESEIGVTLLKRSKRAVRLTAAGGVFLKQIKEGLSQIDQAVD
MAQRTARGELGRLVIGFVGSATYEIMPPIIREYRNRFPSVQIDLRELSTPNQIDALLNGHIDIGVLHPPLGNDELKSYTV
KKSHCVLALPKHHPLTEKARVHLKDLEEESLIVIAKEAWPSLYTEFNFLCEKAGFIPNIAQEATEYQMVIGLVSAGMGIA
VVPTAAKRLFNLDVVYKEIEDFPLRAEWITAHRKDNRNPALKHFIEISDQHS

Sequences:

>Translated_292_residues
MELRHLRYFMVVAEELHFGKAALRLNMTQPPLSQQIKQLESEIGVTLLKRSKRAVRLTAAGGVFLKQIKEGLSQIDQAVD
MAQRTARGELGRLVIGFVGSATYEIMPPIIREYRNRFPSVQIDLRELSTPNQIDALLNGHIDIGVLHPPLGNDELKSYTV
KKSHCVLALPKHHPLTEKARVHLKDLEEESLIVIAKEAWPSLYTEFNFLCEKAGFIPNIAQEATEYQMVIGLVSAGMGIA
VVPTAAKRLFNLDVVYKEIEDFPLRAEWITAHRKDNRNPALKHFIEISDQHS
>Mature_292_residues
MELRHLRYFMVVAEELHFGKAALRLNMTQPPLSQQIKQLESEIGVTLLKRSKRAVRLTAAGGVFLKQIKEGLSQIDQAVD
MAQRTARGELGRLVIGFVGSATYEIMPPIIREYRNRFPSVQIDLRELSTPNQIDALLNGHIDIGVLHPPLGNDELKSYTV
KKSHCVLALPKHHPLTEKARVHLKDLEEESLIVIAKEAWPSLYTEFNFLCEKAGFIPNIAQEATEYQMVIGLVSAGMGIA
VVPTAAKRLFNLDVVYKEIEDFPLRAEWITAHRKDNRNPALKHFIEISDQHS

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=291, Percent_Identity=37.4570446735395, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI2367136, Length=267, Percent_Identity=33.7078651685393, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1788887, Length=287, Percent_Identity=33.4494773519164, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=31.404958677686, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=29.2682926829268, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=26.530612244898, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=23.3898305084746, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788297, Length=270, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787530, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790262, Length=294, Percent_Identity=24.4897959183673, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790208, Length=283, Percent_Identity=25.0883392226148, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=23.9837398373984, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788296, Length=232, Percent_Identity=25.4310344827586, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081904, Length=145, Percent_Identity=29.6551724137931, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787601, Length=288, Percent_Identity=22.9166666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789173, Length=193, Percent_Identity=30.0518134715026, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082132, Length=156, Percent_Identity=33.974358974359, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787949, Length=295, Percent_Identity=27.1186440677966, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789204, Length=250, Percent_Identity=24, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787589, Length=127, Percent_Identity=35.4330708661417, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082024, Length=233, Percent_Identity=23.6051502145923, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789506, Length=192, Percent_Identity=25, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32974; Mature: 32974

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFMVVAEELHFGKAALRLNMTQPPLSQQIKQLESEIGVTLLKRSKRAVRLTAA
CCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GGVFLKQIKEGLSQIDQAVDMAQRTARGELGRLVIGFVGSATYEIMPPIIREYRNRFPSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHCCCHHHHCCHHHHHHHHHCCCE
QIDLRELSTPNQIDALLNGHIDIGVLHPPLGNDELKSYTVKKSHCVLALPKHHPLTEKAR
EEEHHHCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHEEEECCCEEEECCCCCCCCHHHH
VHLKDLEEESLIVIAKEAWPSLYTEFNFLCEKAGFIPNIAQEATEYQMVIGLVSAGMGIA
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEE
VVPTAAKRLFNLDVVYKEIEDFPLRAEWITAHRKDNRNPALKHFIEISDQHS
EECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MELRHLRYFMVVAEELHFGKAALRLNMTQPPLSQQIKQLESEIGVTLLKRSKRAVRLTAA
CCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GGVFLKQIKEGLSQIDQAVDMAQRTARGELGRLVIGFVGSATYEIMPPIIREYRNRFPSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHCCCHHHHCCHHHHHHHHHCCCE
QIDLRELSTPNQIDALLNGHIDIGVLHPPLGNDELKSYTVKKSHCVLALPKHHPLTEKAR
EEEHHHCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHEEEECCCEEEECCCCCCCCHHHH
VHLKDLEEESLIVIAKEAWPSLYTEFNFLCEKAGFIPNIAQEATEYQMVIGLVSAGMGIA
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEE
VVPTAAKRLFNLDVVYKEIEDFPLRAEWITAHRKDNRNPALKHFIEISDQHS
EECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]