BacMap

Definition	Bacillus licheniformis ATCC 14580, complete genome.
Accession	NC_006322
Length	4,222,645

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The map label for this gene is yvgN [H]

Identifier: 52787219

GI number: 52787219

Start: 3370608

End: 3371447

Strand: Reverse

Name: yvgN [H]

Synonym: BLi03528

Alternate gene names: 52787219

Gene position: 3371447-3370608 (Counterclockwise)

Preceding gene: 52787220

Following gene: 52787215

Centisome position: 79.84

GC content: 44.4

Gene sequence:

>840_bases
ATGGTAAGCAGTTTAAAGGACACTGTGACATTACATAACGGTGTGAAAATGCCATGGTTTGGACTTGGAGTTTTCAAAGT
GGAAGAAGGCAGCCAAGTCGTTGAATCTGTAAAAGCAGCCATTAAAAACGGATACCGGAGCATTGACACAGCCGCTATCT
ATCAAAATGAAGAAGGCGTCGGCAAAGGGATTAAGGAATCAGGCGTTCCCCGCGAAGAGCTTTTCATCACGTCAAAGGTT
TGGAACAGTGACCAGGGATATGAAAAAACATTGGCGGCTTTTGATGAAAGCCTTCGAAAACTCGGCCTTGACTACCTTGA
TTTATATTTGATTCATTGGCCAGGAAAAGACAAATATAAAGATACGTGGCGCGCACTTGAAAAGCTGTACAAAGACGGCA
GAGTGAAAGCGATCGGAGTCAGCAATTTCAATGTCCACCATTTGGAAAGCTTATTGGAAGATGCGGAAATTAAACCGATG
GTCAATCAGGTTGAATTCCATCCGCGCCTCACTCAGACTGAGCTTAGGGACTACTGCAAGAAGCAAGGCATTCAGGTGGA
AGCATGGTCTCCGCTCATGCAGGGAAAACTCCTCGATGATCAGGTGCTGACTGACATCGCTAAAAAATACAACAAATCCG
TTGCTCAAGTCATCCTGCGCTGGGATTTGCAAAATGAAGTCGTCACCATTCCGAAGTCCATCAAAGAACACCGCATTATT
GAAAATGCCGACATTTTTGATTTTGAATTATCGGCGGAAGATGTCGAAAAAATCAACGCTCTTAATAAAGATGAGCGCGT
CGGTCCGGATCCGGACACAATGGTTAACGGATTCGAATAA

Upstream 100 bases:

>100_bases
CCATCGGTTGAGCAAGTTGTTTTGTAAAATCCACCCAGTGTGAGATAATAAAAGCGGTGCGTTTAAAAGCATCTGAAAAA
AAGAAAGGTGGTCGTTCAAA

Downstream 100 bases:

>100_bases
TCATAAAAAAATCCCGGGTTTTTATAAACCCGGGATTTTTCATTTCTCATGAATGGCCAAGCGGCCTTTCGCTTGTTTTC
TTTTGCTGCCGTCGAGCCGT

Product: YvgN

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MVSSLKDTVTLHNGVKMPWFGLGVFKVEEGSQVVESVKAAIKNGYRSIDTAAIYQNEEGVGKGIKESGVPREELFITSKV
WNSDQGYEKTLAAFDESLRKLGLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGRVKAIGVSNFNVHHLESLLEDAEIKPM
VNQVEFHPRLTQTELRDYCKKQGIQVEAWSPLMQGKLLDDQVLTDIAKKYNKSVAQVILRWDLQNEVVTIPKSIKEHRII
ENADIFDFELSAEDVEKINALNKDERVGPDPDTMVNGFE

Sequences:

>Translated_279_residues
MVSSLKDTVTLHNGVKMPWFGLGVFKVEEGSQVVESVKAAIKNGYRSIDTAAIYQNEEGVGKGIKESGVPREELFITSKV
WNSDQGYEKTLAAFDESLRKLGLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGRVKAIGVSNFNVHHLESLLEDAEIKPM
VNQVEFHPRLTQTELRDYCKKQGIQVEAWSPLMQGKLLDDQVLTDIAKKYNKSVAQVILRWDLQNEVVTIPKSIKEHRII
ENADIFDFELSAEDVEKINALNKDERVGPDPDTMVNGFE
>Mature_279_residues
MVSSLKDTVTLHNGVKMPWFGLGVFKVEEGSQVVESVKAAIKNGYRSIDTAAIYQNEEGVGKGIKESGVPREELFITSKV
WNSDQGYEKTLAAFDESLRKLGLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGRVKAIGVSNFNVHHLESLLEDAEIKPM
VNQVEFHPRLTQTELRDYCKKQGIQVEAWSPLMQGKLLDDQVLTDIAKKYNKSVAQVILRWDLQNEVVTIPKSIKEHRII
ENADIFDFELSAEDVEKINALNKDERVGPDPDTMVNGFE

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=295, Percent_Identity=43.0508474576271, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI5174391, Length=295, Percent_Identity=43.0508474576271, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI223468663, Length=296, Percent_Identity=42.2297297297297, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI4502049, Length=299, Percent_Identity=43.4782608695652, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI291291012, Length=274, Percent_Identity=41.2408759124088, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI93277124, Length=306, Percent_Identity=38.562091503268, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI5174695, Length=305, Percent_Identity=38.0327868852459, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=39.2086330935252, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=37.9194630872483, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI310109920, Length=298, Percent_Identity=37.9194630872483, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI45446745, Length=298, Percent_Identity=37.9194630872483, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI4503285, Length=298, Percent_Identity=37.9194630872483, Blast_Score=187, Evalue=9e-48,
Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=38.047138047138, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI24497583, Length=296, Percent_Identity=37.5, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI300116273, Length=284, Percent_Identity=36.6197183098592, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI300116271, Length=283, Percent_Identity=36.0424028268551, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=38.961038961039, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=42.4778761061947, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=42.4778761061947, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI87082198, Length=269, Percent_Identity=44.9814126394052, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1786400, Length=261, Percent_Identity=38.3141762452107, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788081, Length=261, Percent_Identity=34.0996168582375, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788070, Length=217, Percent_Identity=27.1889400921659, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081735, Length=278, Percent_Identity=25.5395683453237, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI48994888, Length=254, Percent_Identity=27.9527559055118, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=44.0298507462687, Blast_Score=226, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=38.3333333333333, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17537077, Length=302, Percent_Identity=40.0662251655629, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17537075, Length=307, Percent_Identity=40.0651465798046, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=39, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=35.5311355311355, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537079, Length=305, Percent_Identity=34.7540983606557, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=38.9705882352941, Blast_Score=180, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=31.0469314079422, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17562292, Length=274, Percent_Identity=33.9416058394161, Blast_Score=164, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17566692, Length=303, Percent_Identity=35.3135313531353, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17561300, Length=277, Percent_Identity=35.0180505415162, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17550246, Length=84, Percent_Identity=48.8095238095238, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324694, Length=300, Percent_Identity=41.3333333333333, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320576, Length=298, Percent_Identity=40.2684563758389, Blast_Score=208, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6322556, Length=257, Percent_Identity=39.6887159533074, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321896, Length=323, Percent_Identity=34.3653250773994, Blast_Score=172, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319625, Length=289, Percent_Identity=36.3321799307958, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320079, Length=279, Percent_Identity=37.9928315412186, Blast_Score=159, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24663317, Length=300, Percent_Identity=40.6666666666667, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24657054, Length=291, Percent_Identity=41.2371134020619, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=38.9078498293515, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129731, Length=296, Percent_Identity=38.1756756756757, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=36.9491525423729, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI21356425, Length=301, Percent_Identity=37.2093023255814, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=42.0338983050847, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24662781, Length=295, Percent_Identity=42.0338983050847, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24644950, Length=301, Percent_Identity=35.8803986710963, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI221378297, Length=321, Percent_Identity=33.6448598130841, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=37.109375, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24646155, Length=183, Percent_Identity=32.7868852459016, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 31801; Mature: 31801

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSLKDTVTLHNGVKMPWFGLGVFKVEEGSQVVESVKAAIKNGYRSIDTAAIYQNEEGV
CCCCHHHHHHHCCCCCCCEECCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHEEECCCCC
GKGIKESGVPREELFITSKVWNSDQGYEKTLAAFDESLRKLGLDYLDLYLIHWPGKDKYK
CCCCHHHCCCHHHEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHH
DTWRALEKLYKDGRVKAIGVSNFNVHHLESLLEDAEIKPMVNQVEFHPRLTQTELRDYCK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
KQGIQVEAWSPLMQGKLLDDQVLTDIAKKYNKSVAQVILRWDLQNEVVTIPKSIKEHRII
HCCCEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHH
ENADIFDFELSAEDVEKINALNKDERVGPDPDTMVNGFE
CCCCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MVSSLKDTVTLHNGVKMPWFGLGVFKVEEGSQVVESVKAAIKNGYRSIDTAAIYQNEEGV
CCCCHHHHHHHCCCCCCCEECCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHEEECCCCC
GKGIKESGVPREELFITSKVWNSDQGYEKTLAAFDESLRKLGLDYLDLYLIHWPGKDKYK
CCCCHHHCCCHHHEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHH
DTWRALEKLYKDGRVKAIGVSNFNVHHLESLLEDAEIKPMVNQVEFHPRLTQTELRDYCK
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHH
KQGIQVEAWSPLMQGKLLDDQVLTDIAKKYNKSVAQVILRWDLQNEVVTIPKSIKEHRII
HCCCEEEECCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHH
ENADIFDFELSAEDVEKINALNKDERVGPDPDTMVNGFE
CCCCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]