Click here to switch to the map view.

The map label for this gene is fhuB [H]

Identifier: 52787212

GI number: 52787212

Start: 3363029

End: 3364093

Strand: Reverse

Name: fhuB [H]

Synonym: BLi03521

Alternate gene names: 52787212

Gene position: 3364093-3363029 (Counterclockwise)

Preceding gene: 52787213

Following gene: 52787211

Centisome position: 79.67

GC content: 54.37

Gene sequence:

>1065_bases
GTGAGCTCTTACAAAAACATACATCATATCAACGGCGCGGATGGCACTGATGAAGAACAGAGACCGATCAGCCGTCCGCT
CGGAGCTGTATTTGTCCTGGCCGGCGGAATCATGCTGCTGCTTTTTGGCGCCGCATTATCGATTGCGCTCGGTGCGGCTG
ATATAAAGCTTGGAACGGTTTGGGACGCCATTTTTCATTTTGACGCGAAAAATACGGCCCATCAAATTATTCAGGAACTC
AGACTGCCAAGGACGGTAAGTGCGGCTCTTGTGGGCGCCTGCCTGGCGGTTTCCGGAGCCGTGATGCAGGGGATGACGCG
AAATCCTCTTGCGTCGCCGGAAATTATGAGCGTCACGCACGGGTCAGCTTTCGCAATTGCTGTTGCGTTTGCTTTTTTTC
CAGGAACCTCATCGATCGGGCTGATGATCTGGTCATTTGCCGGTGCCGCTCTTGGAGCGGGGCTTGTTTTTGGAATCGGA
ATGTTTTCAAAAGGCGGTCTTACGCCTGTAAAGCTGGCTTTGGCCGGTACGGCTGTCGGCACGTTCCTGAGCGCTCTTTC
TACGAGCATCGCGATCCACTTTGATGTGGCGCGCGACGTCAGTTTTTGGTATGCCGGAGGTGTCGCCGGCACGAAATGGC
TCAGCATTCAGTTGTTGATTCCGGCGGCAGCGCTCGGTTTGGCGGTCGTTTTTGTCATCGCCCGTTCCATCACGGTTCTA
AGCCTGGGTGAGGAGCTGGCGAAAGGGCTCGGTCAATATACGAAGACGGTAAAAGCGATCGGCATCGTGTCCGTTGTTCT
GCTGACGGGTGCCACTGTATCCGTTGCCGGTGCGATCGGTTTTATCGGATTGATCATTCCGCATATTACCCGCTTTCTGG
TCGGGGTTGATTACCGCTGGATCATTCCATGCTCAGCTGTGCTTGGCGCTGTTCTTCTGATCTATGCGGATATTGCGGCA
AGGCTGGTCAACCCGCCGTTTGAAACACCTGTCGGAGCAGTAACTGCGCTTGTCGGCGTACCATTCTTTCTCTATCTGGC
CCGCAGGGAAAGGAGTGGACTGTAA

Upstream 100 bases:

>100_bases
CTGCCGAAAATTTTGATTAAAATTTTTGCTTAGGCCTGTTATACTAAACATGAAAATGATAATCGTTATCGGTTAAAAAG
ATCGAAAGGAATGGCATCGA

Downstream 100 bases:

>100_bases
TGCTCAAGAAAAACAACAGACGGGCGGGTGCGGTGATGCTCGTCATGGCCGTGCTGACGGCCGCCGTGTTTTTATTAAGC
ATGAACATGGGAGAAATCCG

Product: FhuB

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSSYKNIHHINGADGTDEEQRPISRPLGAVFVLAGGIMLLLFGAALSIALGAADIKLGTVWDAIFHFDAKNTAHQIIQEL
RLPRTVSAALVGACLAVSGAVMQGMTRNPLASPEIMSVTHGSAFAIAVAFAFFPGTSSIGLMIWSFAGAALGAGLVFGIG
MFSKGGLTPVKLALAGTAVGTFLSALSTSIAIHFDVARDVSFWYAGGVAGTKWLSIQLLIPAAALGLAVVFVIARSITVL
SLGEELAKGLGQYTKTVKAIGIVSVVLLTGATVSVAGAIGFIGLIIPHITRFLVGVDYRWIIPCSAVLGAVLLIYADIAA
RLVNPPFETPVGAVTALVGVPFFLYLARRERSGL

Sequences:

>Translated_354_residues
MSSYKNIHHINGADGTDEEQRPISRPLGAVFVLAGGIMLLLFGAALSIALGAADIKLGTVWDAIFHFDAKNTAHQIIQEL
RLPRTVSAALVGACLAVSGAVMQGMTRNPLASPEIMSVTHGSAFAIAVAFAFFPGTSSIGLMIWSFAGAALGAGLVFGIG
MFSKGGLTPVKLALAGTAVGTFLSALSTSIAIHFDVARDVSFWYAGGVAGTKWLSIQLLIPAAALGLAVVFVIARSITVL
SLGEELAKGLGQYTKTVKAIGIVSVVLLTGATVSVAGAIGFIGLIIPHITRFLVGVDYRWIIPCSAVLGAVLLIYADIAA
RLVNPPFETPVGAVTALVGVPFFLYLARRERSGL
>Mature_353_residues
SSYKNIHHINGADGTDEEQRPISRPLGAVFVLAGGIMLLLFGAALSIALGAADIKLGTVWDAIFHFDAKNTAHQIIQELR
LPRTVSAALVGACLAVSGAVMQGMTRNPLASPEIMSVTHGSAFAIAVAFAFFPGTSSIGLMIWSFAGAALGAGLVFGIGM
FSKGGLTPVKLALAGTAVGTFLSALSTSIAIHFDVARDVSFWYAGGVAGTKWLSIQLLIPAAALGLAVVFVIARSITVLS
LGEELAKGLGQYTKTVKAIGIVSVVLLTGATVSVAGAIGFIGLIIPHITRFLVGVDYRWIIPCSAVLGAVLLIYADIAAR
LVNPPFETPVGAVTALVGVPFFLYLARRERSGL

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=308, Percent_Identity=34.0909090909091, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790740, Length=314, Percent_Identity=35.6687898089172, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1790741, Length=280, Percent_Identity=37.8571428571429, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788004, Length=278, Percent_Identity=37.0503597122302, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786347, Length=347, Percent_Identity=28.2420749279539, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786804, Length=302, Percent_Identity=30.4635761589404, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36630; Mature: 36498

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYKNIHHINGADGTDEEQRPISRPLGAVFVLAGGIMLLLFGAALSIALGAADIKLGTV
CCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEHHHH
WDAIFHFDAKNTAHQIIQELRLPRTVSAALVGACLAVSGAVMQGMTRNPLASPEIMSVTH
HHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECC
GSAFAIAVAFAFFPGTSSIGLMIWSFAGAALGAGLVFGIGMFSKGGLTPVKLALAGTAVG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TFLSALSTSIAIHFDVARDVSFWYAGGVAGTKWLSIQLLIPAAALGLAVVFVIARSITVL
HHHHHHHHHHEEEEEHHHCCHHHEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
SLGEELAKGLGQYTKTVKAIGIVSVVLLTGATVSVAGAIGFIGLIIPHITRFLVGVDYRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IIPCSAVLGAVLLIYADIAARLVNPPFETPVGAVTALVGVPFFLYLARRERSGL
EECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSYKNIHHINGADGTDEEQRPISRPLGAVFVLAGGIMLLLFGAALSIALGAADIKLGTV
CCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEHHHH
WDAIFHFDAKNTAHQIIQELRLPRTVSAALVGACLAVSGAVMQGMTRNPLASPEIMSVTH
HHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECC
GSAFAIAVAFAFFPGTSSIGLMIWSFAGAALGAGLVFGIGMFSKGGLTPVKLALAGTAVG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TFLSALSTSIAIHFDVARDVSFWYAGGVAGTKWLSIQLLIPAAALGLAVVFVIARSITVL
HHHHHHHHHHEEEEEHHHCCHHHEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHH
SLGEELAKGLGQYTKTVKAIGIVSVVLLTGATVSVAGAIGFIGLIIPHITRFLVGVDYRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IIPCSAVLGAVLLIYADIAARLVNPPFETPVGAVTALVGVPFFLYLARRERSGL
EECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]