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The map label for this gene is czcD [H]

Identifier: 52787144

GI number: 52787144

Start: 3298031

End: 3298966

Strand: Reverse

Name: czcD [H]

Synonym: BLi03452

Alternate gene names: 52787144

Gene position: 3298966-3298031 (Counterclockwise)

Preceding gene: 52787145

Following gene: 52787143

Centisome position: 78.13

GC content: 49.68

Gene sequence:

>936_bases
ATGGCTCATTCTCACGGACATACAGGACACAGCCACCATGGCAGCCGATCAGCAAATCAAAAAGCGCTGTTCATCAGCTT
CGGTTTAATTTTTACTTTTATGATGATTGAAGTGATAGGCGGAATATTGACGAACAGCCTCGCTTTGCTGTCAGATGCGG
GACATATGCTCAGCGACGCTGCGGCGCTTGGCTTCAGCCTCTTGGCGTTTAAAATTGGGGAAAAGGCCGCAAGCGCGAGC
AAAACATTCGGCTACAGGCGCTTTGAGATTTTGGCTGCGTTTATCAATGGCATCACCCTGCTTTTGATTTCACTTTATAT
TTTTTGGGAAGCATACAATCGCTTTTTCAGCCCGCCGGAAGTCGCGGGAAGGGGTATGCTTGCGATTGCGACGGTTGGTC
TGTTCGTCAACATTGCTGCGGCCTGGGTAATAATGAAAGGCGACACAAGCGGGAATTTAAATATGCGGAGCGCTTTTTTG
CACATCATCGGCGATATGCTGGGCTCTTTCGGGGCGATCATCGCGGGCCTCCTTATGCTTTTCTTCAATTGGAACATCGC
CGATCCAATCGCCAGCGCCGTCGTCGCTGCTTTGGTTCTCGTCAGCGGCTGGCGGGTGACGAAAGACTCGGTGCATATAT
TAATGGAAGGAAAACCGAAAGACATTGATGCGGAGGCGCTTAAAAACGGCCTGCTTTCCATCCCGTCGGTCAGGGAGGTT
CACGACCTCCACATTTGGTCGATCTCATCCGATATGCCGTCATTAAGCTGCCATATCGTAGCGGATGAAAACAGTGACAG
GGATAGAATTTTAAAACAAGTATCAAAATATCTAAGGAAAGAATGCAACGTGGAGCATGTGACGGTTCAAATAGAAGGGG
AGCGCTGTTCCCCTCATGAATCGTGCAGCCTGGGAGCAAACCATCCCCGCTCTTAA

Upstream 100 bases:

>100_bases
TTCTCCATGTTCTTAGAAGCCGCTTGACCTTAATTAAAGGAAAAGGTAAAATTTAAATATGAATACATGATCATATATCA
ATTTAAGAGGAGGATTTAAA

Downstream 100 bases:

>100_bases
TGACGGATGTACCGATTGTTTTCGACAGCTTGGTAATAAATTCCGCTTTTCTGCCCCGGGAAGTTTTCTTGTCCCAATCT
CTTTAAGAACAAATCGTTTT

Product: CzcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAHSHGHTGHSHHGSRSANQKALFISFGLIFTFMMIEVIGGILTNSLALLSDAGHMLSDAAALGFSLLAFKIGEKAASAS
KTFGYRRFEILAAFINGITLLLISLYIFWEAYNRFFSPPEVAGRGMLAIATVGLFVNIAAAWVIMKGDTSGNLNMRSAFL
HIIGDMLGSFGAIIAGLLMLFFNWNIADPIASAVVAALVLVSGWRVTKDSVHILMEGKPKDIDAEALKNGLLSIPSVREV
HDLHIWSISSDMPSLSCHIVADENSDRDRILKQVSKYLRKECNVEHVTVQIEGERCSPHESCSLGANHPRS

Sequences:

>Translated_311_residues
MAHSHGHTGHSHHGSRSANQKALFISFGLIFTFMMIEVIGGILTNSLALLSDAGHMLSDAAALGFSLLAFKIGEKAASAS
KTFGYRRFEILAAFINGITLLLISLYIFWEAYNRFFSPPEVAGRGMLAIATVGLFVNIAAAWVIMKGDTSGNLNMRSAFL
HIIGDMLGSFGAIIAGLLMLFFNWNIADPIASAVVAALVLVSGWRVTKDSVHILMEGKPKDIDAEALKNGLLSIPSVREV
HDLHIWSISSDMPSLSCHIVADENSDRDRILKQVSKYLRKECNVEHVTVQIEGERCSPHESCSLGANHPRS
>Mature_310_residues
AHSHGHTGHSHHGSRSANQKALFISFGLIFTFMMIEVIGGILTNSLALLSDAGHMLSDAAALGFSLLAFKIGEKAASASK
TFGYRRFEILAAFINGITLLLISLYIFWEAYNRFFSPPEVAGRGMLAIATVGLFVNIAAAWVIMKGDTSGNLNMRSAFLH
IIGDMLGSFGAIIAGLLMLFFNWNIADPIASAVVAALVLVSGWRVTKDSVHILMEGKPKDIDAEALKNGLLSIPSVREVH
DLHIWSISSDMPSLSCHIVADENSDRDRILKQVSKYLRKECNVEHVTVQIEGERCSPHESCSLGANHPRS

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=304, Percent_Identity=31.9078947368421, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=29.1946308724832, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI20070323, Length=325, Percent_Identity=30.1538461538462, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=29.7029702970297, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=29.7029702970297, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=29.7029702970297, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=29.7029702970297, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI64762489, Length=303, Percent_Identity=29.7029702970297, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI21359890, Length=309, Percent_Identity=29.4498381877023, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=31.9444444444444, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI222080086, Length=123, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=123, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI52352803, Length=127, Percent_Identity=37.007874015748, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI52351208, Length=162, Percent_Identity=27.1604938271605, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786966, Length=279, Percent_Identity=44.8028673835125, Blast_Score=214, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=33.1210191082803, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17555794, Length=322, Percent_Identity=30.7453416149068, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17555796, Length=304, Percent_Identity=30.5921052631579, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=286, Percent_Identity=31.8181818181818, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320411, Length=181, Percent_Identity=39.2265193370166, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=147, Percent_Identity=29.9319727891156, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324892, Length=148, Percent_Identity=25.6756756756757, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583858, Length=337, Percent_Identity=27.299703264095, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24584409, Length=165, Percent_Identity=32.7272727272727, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574430, Length=165, Percent_Identity=32.7272727272727, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24645863, Length=140, Percent_Identity=31.4285714285714, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585900, Length=143, Percent_Identity=29.3706293706294, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585898, Length=143, Percent_Identity=29.3706293706294, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585896, Length=143, Percent_Identity=29.3706293706294, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921672, Length=143, Percent_Identity=29.3706293706294, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24656728, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656724, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656720, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24656715, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357035, Length=146, Percent_Identity=31.5068493150685, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33803; Mature: 33671

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSHGHTGHSHHGSRSANQKALFISFGLIFTFMMIEVIGGILTNSLALLSDAGHMLSDA
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALGFSLLAFKIGEKAASASKTFGYRRFEILAAFINGITLLLISLYIFWEAYNRFFSPPE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VAGRGMLAIATVGLFVNIAAAWVIMKGDTSGNLNMRSAFLHIIGDMLGSFGAIIAGLLML
HHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFNWNIADPIASAVVAALVLVSGWRVTKDSVHILMEGKPKDIDAEALKNGLLSIPSVREV
HHCCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCHHHHHCCCCCCCCHHHH
HDLHIWSISSDMPSLSCHIVADENSDRDRILKQVSKYLRKECNVEHVTVQIEGERCSPHE
HHEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCC
SCSLGANHPRS
CCCCCCCCCCC
>Mature Secondary Structure 
AHSHGHTGHSHHGSRSANQKALFISFGLIFTFMMIEVIGGILTNSLALLSDAGHMLSDA
CCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALGFSLLAFKIGEKAASASKTFGYRRFEILAAFINGITLLLISLYIFWEAYNRFFSPPE
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VAGRGMLAIATVGLFVNIAAAWVIMKGDTSGNLNMRSAFLHIIGDMLGSFGAIIAGLLML
HHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFNWNIADPIASAVVAALVLVSGWRVTKDSVHILMEGKPKDIDAEALKNGLLSIPSVREV
HHCCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCHHHHHCCCCCCCCHHHH
HDLHIWSISSDMPSLSCHIVADENSDRDRILKQVSKYLRKECNVEHVTVQIEGERCSPHE
HHEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCC
SCSLGANHPRS
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA