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The map label for this gene is comP [H]

Identifier: 52787049

GI number: 52787049

Start: 3205766

End: 3206992

Strand: Reverse

Name: comP [H]

Synonym: BLi03354

Alternate gene names: 52787049

Gene position: 3206992-3205766 (Counterclockwise)

Preceding gene: 52787050

Following gene: 52787048

Centisome position: 75.95

GC content: 44.58

Gene sequence:

>1227_bases
GTGTTTTTTCTAAGTCTCATTTTAACGGGTCAGTTCAATTTTATTATGCTAGGTGTTTTTTATCTCAAAGAAATTCTTGA
TTTTCGTTTCCGTTTAAAAAGGTTTTCTGAAAAATTTAATTACCAAGATAGTGTATTTAAGTTTACCCAACTTATACGGA
GCTCGACATCGTTAGCGCAAGTGCTAAGGGAATTGTCTCAAACGATTCTTGATGTTTTACCTGTCAGCCAGGCTTATGTA
CTGGAGTTAAAGAGTGATGGAACCGTAGGGTTACTTGAAAATAATGCAAACGATCAAGTTTGGAAGCCTTATGAAAAAGA
AGCTTTTAGGGCTATCACCGACATCGGCAAAATCGTCGAAGTCGACCGTGGGTTTTTGATTAAGATCGGTGAACGGGGCG
GGACGTCTTATGTCATGCTGTGTTTGTCGGTTTTAAATACGCCTAGGCTGACGCGCGATGAGATTTCATGGCTTGAGACG
CTGGCGTTTTATACGAGCGTTTCCCTGGAAAACGTGCTGAAAATCGGCGAGCTGATGGAGCATCTGGAAAATGTGAAAAA
AGAAGGGCCGAATCCGGCGTGGCTGAATAAATTGATGTTTGCGATTGAAGAGAAGCAGAGATCTGATTTAGCCCGCGATC
TCCACGACTCTGTCCTGCAGGATATGATTTCCTTGAAGCATCAAAGCGAGATGTTTCTGGCTGATTTTGAAAAAGATAAA
GTCTGTACGAATCAAATCCGGCAAAGGCTCATCAATATGAATGAGCAAATGTCCGCCGTCATCCAGACGACAAGGGAAAC
GTGCCAGGAGCTGAGGCCGCAGCTGTTGTACGATCTCGGACTTGTCAAAGCCCTTTCGAAACTGGCGGCGCAGCATCAGG
AGTCCTCATCGATCGATAAGATCCGCCTCAATACGGAAAGGTTCTCAAAGGTGCTCGACTTGGACACGCAGTTGAATTTG
TACAGAATTGTGCAGGAGCTTTTAAGCAATGCGGTTAAACATTCGAGAGCTAATGAGGTTTTGATTATGCTTGTCTGCAT
AAAAGAAAAAGTTGTTCTTCATTATGAAGATGACGGCATTGGGGTTGACCCGGACAAGCTTTATCAAAACAGCGCAAGCA
TGGGGCTGTCGGGCATTCGCGAGCGCGTCCGCGCACTGAACGGCAGTCTGGATATACAGACAGCAGAAGGGAAAGGCTTT
AGGGTCGCCATTGAAATGGGATTGTAA

Upstream 100 bases:

>100_bases
ACAAATTGTAAATCAATACATGTATCGATATAATCATGTACGAATTCAGGCAAAATTAAACTACCTGTCCCCACTGGAAT
ACAGGGGACAGGCAGCATAG

Downstream 100 bases:

>100_bases
TGTTTAGTTAACATTTTTGCTTGGCATCCGCCAAGTTTTTTCTATAAAATGGTGATAGGGCAAGGTTACGCAAAAGGGAG
GAAATTATGAGAAGATTACT

Product: ComP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MFFLSLILTGQFNFIMLGVFYLKEILDFRFRLKRFSEKFNYQDSVFKFTQLIRSSTSLAQVLRELSQTILDVLPVSQAYV
LELKSDGTVGLLENNANDQVWKPYEKEAFRAITDIGKIVEVDRGFLIKIGERGGTSYVMLCLSVLNTPRLTRDEISWLET
LAFYTSVSLENVLKIGELMEHLENVKKEGPNPAWLNKLMFAIEEKQRSDLARDLHDSVLQDMISLKHQSEMFLADFEKDK
VCTNQIRQRLINMNEQMSAVIQTTRETCQELRPQLLYDLGLVKALSKLAAQHQESSSIDKIRLNTERFSKVLDLDTQLNL
YRIVQELLSNAVKHSRANEVLIMLVCIKEKVVLHYEDDGIGVDPDKLYQNSASMGLSGIRERVRALNGSLDIQTAEGKGF
RVAIEMGL

Sequences:

>Translated_408_residues
MFFLSLILTGQFNFIMLGVFYLKEILDFRFRLKRFSEKFNYQDSVFKFTQLIRSSTSLAQVLRELSQTILDVLPVSQAYV
LELKSDGTVGLLENNANDQVWKPYEKEAFRAITDIGKIVEVDRGFLIKIGERGGTSYVMLCLSVLNTPRLTRDEISWLET
LAFYTSVSLENVLKIGELMEHLENVKKEGPNPAWLNKLMFAIEEKQRSDLARDLHDSVLQDMISLKHQSEMFLADFEKDK
VCTNQIRQRLINMNEQMSAVIQTTRETCQELRPQLLYDLGLVKALSKLAAQHQESSSIDKIRLNTERFSKVLDLDTQLNL
YRIVQELLSNAVKHSRANEVLIMLVCIKEKVVLHYEDDGIGVDPDKLYQNSASMGLSGIRERVRALNGSLDIQTAEGKGF
RVAIEMGL
>Mature_408_residues
MFFLSLILTGQFNFIMLGVFYLKEILDFRFRLKRFSEKFNYQDSVFKFTQLIRSSTSLAQVLRELSQTILDVLPVSQAYV
LELKSDGTVGLLENNANDQVWKPYEKEAFRAITDIGKIVEVDRGFLIKIGERGGTSYVMLCLSVLNTPRLTRDEISWLET
LAFYTSVSLENVLKIGELMEHLENVKKEGPNPAWLNKLMFAIEEKQRSDLARDLHDSVLQDMISLKHQSEMFLADFEKDK
VCTNQIRQRLINMNEQMSAVIQTTRETCQELRPQLLYDLGLVKALSKLAAQHQESSSIDKIRLNTERFSKVLDLDTQLNL
YRIVQELLSNAVKHSRANEVLIMLVCIKEKVVLHYEDDGIGVDPDKLYQNSASMGLSGIRERVRALNGSLDIQTAEGKGF
RVAIEMGL

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=205, Percent_Identity=31.7073170731707, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788812, Length=205, Percent_Identity=27.3170731707317, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787474, Length=200, Percent_Identity=26, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46717; Mature: 46717

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFLSLILTGQFNFIMLGVFYLKEILDFRFRLKRFSEKFNYQDSVFKFTQLIRSSTSLAQ
CHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHH
VLRELSQTILDVLPVSQAYVLELKSDGTVGLLENNANDQVWKPYEKEAFRAITDIGKIVE
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
VDRGFLIKIGERGGTSYVMLCLSVLNTPRLTRDEISWLETLAFYTSVSLENVLKIGELME
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLENVKKEGPNPAWLNKLMFAIEEKQRSDLARDLHDSVLQDMISLKHQSEMFLADFEKDK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VCTNQIRQRLINMNEQMSAVIQTTRETCQELRPQLLYDLGLVKALSKLAAQHQESSSIDK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IRLNTERFSKVLDLDTQLNLYRIVQELLSNAVKHSRANEVLIMLVCIKEKVVLHYEDDGI
EEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCEEEEECCCCC
GVDPDKLYQNSASMGLSGIRERVRALNGSLDIQTAEGKGFRVAIEMGL
CCCHHHHHHCHHHCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
>Mature Secondary Structure
MFFLSLILTGQFNFIMLGVFYLKEILDFRFRLKRFSEKFNYQDSVFKFTQLIRSSTSLAQ
CHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHH
VLRELSQTILDVLPVSQAYVLELKSDGTVGLLENNANDQVWKPYEKEAFRAITDIGKIVE
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
VDRGFLIKIGERGGTSYVMLCLSVLNTPRLTRDEISWLETLAFYTSVSLENVLKIGELME
CCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLENVKKEGPNPAWLNKLMFAIEEKQRSDLARDLHDSVLQDMISLKHQSEMFLADFEKDK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VCTNQIRQRLINMNEQMSAVIQTTRETCQELRPQLLYDLGLVKALSKLAAQHQESSSIDK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
IRLNTERFSKVLDLDTQLNLYRIVQELLSNAVKHSRANEVLIMLVCIKEKVVLHYEDDGI
EEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCEEEEECCCCC
GVDPDKLYQNSASMGLSGIRERVRALNGSLDIQTAEGKGFRVAIEMGL
CCCHHHHHHCHHHCCHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]