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The map label for this gene is comA [H]

Identifier: 52787048

GI number: 52787048

Start: 3205041

End: 3205679

Strand: Reverse

Name: comA [H]

Synonym: BLi03353

Alternate gene names: 52787048

Gene position: 3205679-3205041 (Counterclockwise)

Preceding gene: 52787049

Following gene: 52787047

Centisome position: 75.92

GC content: 41.63

Gene sequence:

>639_bases
ATGAGAAGATTACTTGTGATCGATGATCATCCGGCTGTCATGGAGGGGACGAAGGCAATTCTTGAAACGAACCAGGACTT
TGTTGTCGATTGCCTCAGCCCTGAAGCCAGCGAACAATTTCTCAAGAAACATGATTTTTCTGCGTATGACCTGATCTTAA
TGGATTTAAATTTGGGTGAAATCAACGGCATGGACCTATCTAAGAAAATCCTTGAGACATGTTCATCATGCAAAATTATC
GTTTACACAGGCTATGAAGTCGAAGATTATTTTGAAGAGGCGATTCGTTCCGGCATGCACGGCGCCATCAGCAAAACGGA
ATCGAAGGAAAAGATTATAGAGTACATATATCAGGTTCTGGATAATAAAATTGTCGTCGATTATGATTATTTCAAGCAGT
TGATTACACAGCAAAAATCGAAGTCAAACAGCCAGCAGACCCAGCACGACCTCTTGACTGAAAGGGAATGCCTGATTTTA
AAAGAAGTCGAAAAAGGCTACACAAATCAGGAAATTGCTGATGCGCTTCATTTAAGCAAGCGGTCGATCGAATACAGCTT
GACTTCCGTATTCAGCAAGCTGAATGTAGGATCAAGGACAGAGGCTGTTTTAATCGCGAAATCTGAAGGTGTACTCTGA

Upstream 100 bases:

>100_bases
AAATGGGATTGTAATGTTTAGTTAACATTTTTGCTTGGCATCCGCCAAGTTTTTTCTATAAAATGGTGATAGGGCAAGGT
TACGCAAAAGGGAGGAAATT

Downstream 100 bases:

>100_bases
TGAGGGGACGATTGTGATGGAAACGAAACATACACTTCTTGAAGCGTTGGGAATCGAGTTGAAGGAGTGCAGCAAAGAAC
GGTGTGTTGCCGTCATGCCT

Product: ComA

Products: NA

Alternate protein names: Competence protein A [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRRLLVIDDHPAVMEGTKAILETNQDFVVDCLSPEASEQFLKKHDFSAYDLILMDLNLGEINGMDLSKKILETCSSCKII
VYTGYEVEDYFEEAIRSGMHGAISKTESKEKIIEYIYQVLDNKIVVDYDYFKQLITQQKSKSNSQQTQHDLLTERECLIL
KEVEKGYTNQEIADALHLSKRSIEYSLTSVFSKLNVGSRTEAVLIAKSEGVL

Sequences:

>Translated_212_residues
MRRLLVIDDHPAVMEGTKAILETNQDFVVDCLSPEASEQFLKKHDFSAYDLILMDLNLGEINGMDLSKKILETCSSCKII
VYTGYEVEDYFEEAIRSGMHGAISKTESKEKIIEYIYQVLDNKIVVDYDYFKQLITQQKSKSNSQQTQHDLLTERECLIL
KEVEKGYTNQEIADALHLSKRSIEYSLTSVFSKLNVGSRTEAVLIAKSEGVL
>Mature_212_residues
MRRLLVIDDHPAVMEGTKAILETNQDFVVDCLSPEASEQFLKKHDFSAYDLILMDLNLGEINGMDLSKKILETCSSCKII
VYTGYEVEDYFEEAIRSGMHGAISKTESKEKIIEYIYQVLDNKIVVDYDYFKQLITQQKSKSNSQQTQHDLLTERECLIL
KEVEKGYTNQEIADALHLSKRSIEYSLTSVFSKLNVGSRTEAVLIAKSEGVL

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=213, Percent_Identity=27.2300469483568, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788521, Length=208, Percent_Identity=24.0384615384615, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786747, Length=210, Percent_Identity=25.2380952380952, Blast_Score=68, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24147; Mature: 24147

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLLVIDDHPAVMEGTKAILETNQDFVVDCLSPEASEQFLKKHDFSAYDLILMDLNLGE
CCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCC
INGMDLSKKILETCSSCKIIVYTGYEVEDYFEEAIRSGMHGAISKTESKEKIIEYIYQVL
CCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHH
DNKIVVDYDYFKQLITQQKSKSNSQQTQHDLLTERECLILKEVEKGYTNQEIADALHLSK
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RSIEYSLTSVFSKLNVGSRTEAVLIAKSEGVL
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MRRLLVIDDHPAVMEGTKAILETNQDFVVDCLSPEASEQFLKKHDFSAYDLILMDLNLGE
CCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCC
INGMDLSKKILETCSSCKIIVYTGYEVEDYFEEAIRSGMHGAISKTESKEKIIEYIYQVL
CCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHH
DNKIVVDYDYFKQLITQQKSKSNSQQTQHDLLTERECLILKEVEKGYTNQEIADALHLSK
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RSIEYSLTSVFSKLNVGSRTEAVLIAKSEGVL
HHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377 [H]