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The map label for this gene is patB [H]

Identifier: 52787022

GI number: 52787022

Start: 3183495

End: 3184658

Strand: Direct

Name: patB [H]

Synonym: BLi03326

Alternate gene names: 52787022

Gene position: 3183495-3184658 (Clockwise)

Preceding gene: 52787019

Following gene: 52787024

Centisome position: 75.39

GC content: 51.37

Gene sequence:

>1164_bases
ATGGATTTTAATACAGAGCATAACAGACGCGGGACCCAGTCTGTAAAGTGGGACTTAACACAGGAATTATTCGGCGTAAA
TGACGCGCTTCCAATGTGGGTGGCTGATATGGATTTTCGTGCCCCTCAGCCTGTTATTGACGCCCTTCAGCAGCGCCTGG
AGCACGGGGTTTTCGGCTATACATCTGCAAACGCGGGCACGAAGGAAGCTGTCACCGATTGGCTCAGCCGCCGGCACGGA
TGGAATACTGAACCGGCGTTTATCACCTTCAGCCCGGGCATTGTAACAGCGCTCGCCCAAGCGGTTCAGGCGTACACAGA
GCCTGGCGAGCGGGTGGTCGTACAGCCGCCTGTATATACGCCGTTCTTTGATATAGTTGAAAAAAACGGGCGGGTTGTTT
TACATAATCCATTAATCGAAAAAGACGGCCGCTATGAAATGGATTTTTCCGACCTTGAAAAAAAGCTTGTGGAACCGGAT
GTCAAGCTGTTCATTCTTTGCAATCCGCATAACCCTTCCGGCCGTTCATGGTCGAAAGAGGAACTGACAACGCTTGGCGA
ACTCTGCCTTAAACACGGTGTCACAGTTGTTTCCGACGAAATCCACTCGGACCTGATGCTGAACGGACTGAACCATACGC
CGTTCGCCTCTTTATCTCCGGAATTCGCGGATATATCCATCACATGCATTGCACCGAGCAAAACGTTTAACTTGGCCGGG
TTGCAGGCCTCAGCCATCATCATACCCGACAAAGCGAAGAGAACCGCCTTTGCAAAGGTCATGCAGCGTCAGGGACTGCA
TTCTTTAAATACATTTGCGATTGCAGCCATCGAGGCGGCCTATTCAAAAGGCGAACCATGGCTCGATCAGCTTATCCCAT
ACATTGAACGAAATATGGAAGAAGTCCGCCGCTTTTTGGCAGAGGAGCTGCCCGAGGTCCGCATGATGGAGCCTGACGCC
TCTTACTTGGCATGGCTTGACTGCCGAAAGCTCGGATTGTCGGATCAGGACATCAAACGGCTTCTCCTTCATAAAGGAAA
GCTGATTCTTGAGCCGGGACCGAAGTACGGACCGGGCGGAGAAGGATTCGTCAGAATGAATGTCGGATGTTCGCTCTCTG
TTGTAAAAGACGGACTCCGACGTCTGAAGACCGCTTTTTCGTAA

Upstream 100 bases:

>100_bases
CCACTCCCTTTATTTTATAAAAGCTTTCATGGTTAAAACATTGCAATCTATCCTTTTCACAGTTAATGTATAACATATGA
AAAAGACATGAGGTGAGATC

Downstream 100 bases:

>100_bases
GCGTTCCGGCTGAAAGCCGGGCGCTTCTAAGAGCGTTTATGGATGGTTTCATTCAATTCTCTTTCCAGCTTTTCCGCTTT
TTCAGCTTCTTTTTTGGAAT

Product: hypothetical protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDFNTEHNRRGTQSVKWDLTQELFGVNDALPMWVADMDFRAPQPVIDALQQRLEHGVFGYTSANAGTKEAVTDWLSRRHG
WNTEPAFITFSPGIVTALAQAVQAYTEPGERVVVQPPVYTPFFDIVEKNGRVVLHNPLIEKDGRYEMDFSDLEKKLVEPD
VKLFILCNPHNPSGRSWSKEELTTLGELCLKHGVTVVSDEIHSDLMLNGLNHTPFASLSPEFADISITCIAPSKTFNLAG
LQASAIIIPDKAKRTAFAKVMQRQGLHSLNTFAIAAIEAAYSKGEPWLDQLIPYIERNMEEVRRFLAEELPEVRMMEPDA
SYLAWLDCRKLGLSDQDIKRLLLHKGKLILEPGPKYGPGGEGFVRMNVGCSLSVVKDGLRRLKTAFS

Sequences:

>Translated_387_residues
MDFNTEHNRRGTQSVKWDLTQELFGVNDALPMWVADMDFRAPQPVIDALQQRLEHGVFGYTSANAGTKEAVTDWLSRRHG
WNTEPAFITFSPGIVTALAQAVQAYTEPGERVVVQPPVYTPFFDIVEKNGRVVLHNPLIEKDGRYEMDFSDLEKKLVEPD
VKLFILCNPHNPSGRSWSKEELTTLGELCLKHGVTVVSDEIHSDLMLNGLNHTPFASLSPEFADISITCIAPSKTFNLAG
LQASAIIIPDKAKRTAFAKVMQRQGLHSLNTFAIAAIEAAYSKGEPWLDQLIPYIERNMEEVRRFLAEELPEVRMMEPDA
SYLAWLDCRKLGLSDQDIKRLLLHKGKLILEPGPKYGPGGEGFVRMNVGCSLSVVKDGLRRLKTAFS
>Mature_387_residues
MDFNTEHNRRGTQSVKWDLTQELFGVNDALPMWVADMDFRAPQPVIDALQQRLEHGVFGYTSANAGTKEAVTDWLSRRHG
WNTEPAFITFSPGIVTALAQAVQAYTEPGERVVVQPPVYTPFFDIVEKNGRVVLHNPLIEKDGRYEMDFSDLEKKLVEPD
VKLFILCNPHNPSGRSWSKEELTTLGELCLKHGVTVVSDEIHSDLMLNGLNHTPFASLSPEFADISITCIAPSKTFNLAG
LQASAIIIPDKAKRTAFAKVMQRQGLHSLNTFAIAAIEAAYSKGEPWLDQLIPYIERNMEEVRRFLAEELPEVRMMEPDA
SYLAWLDCRKLGLSDQDIKRLLLHKGKLILEPGPKYGPGGEGFVRMNVGCSLSVVKDGLRRLKTAFS

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=210, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI56713254, Length=210, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI95147551, Length=317, Percent_Identity=23.6593059936909, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI169881279, Length=317, Percent_Identity=23.6593059936909, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=34.2783505154639, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI1788627, Length=278, Percent_Identity=24.1007194244604, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786816, Length=285, Percent_Identity=23.859649122807, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=248, Percent_Identity=25, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=248, Percent_Identity=25, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17567663, Length=304, Percent_Identity=23.3552631578947, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=255, Percent_Identity=23.1372549019608, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=217, Percent_Identity=28.110599078341, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573069, Length=257, Percent_Identity=24.5136186770428, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646114, Length=257, Percent_Identity=24.5136186770428, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573067, Length=257, Percent_Identity=24.5136186770428, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573065, Length=257, Percent_Identity=24.5136186770428, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI18859735, Length=233, Percent_Identity=23.175965665236, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43322; Mature: 43322

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNTEHNRRGTQSVKWDLTQELFGVNDALPMWVADMDFRAPQPVIDALQQRLEHGVFGY
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEE
TSANAGTKEAVTDWLSRRHGWNTEPAFITFSPGIVTALAQAVQAYTEPGERVVVQPPVYT
ECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCC
PFFDIVEKNGRVVLHNPLIEKDGRYEMDFSDLEKKLVEPDVKLFILCNPHNPSGRSWSKE
HHHHHHHCCCCEEEECCCCCCCCCEECCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHH
ELTTLGELCLKHGVTVVSDEIHSDLMLNGLNHTPFASLSPEFADISITCIAPSKTFNLAG
HHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECC
LQASAIIIPDKAKRTAFAKVMQRQGLHSLNTFAIAAIEAAYSKGEPWLDQLIPYIERNME
CEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHH
EVRRFLAEELPEVRMMEPDASYLAWLDCRKLGLSDQDIKRLLLHKGKLILEPGPKYGPGG
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
EGFVRMNVGCSLSVVKDGLRRLKTAFS
CCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFNTEHNRRGTQSVKWDLTQELFGVNDALPMWVADMDFRAPQPVIDALQQRLEHGVFGY
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEE
TSANAGTKEAVTDWLSRRHGWNTEPAFITFSPGIVTALAQAVQAYTEPGERVVVQPPVYT
ECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCC
PFFDIVEKNGRVVLHNPLIEKDGRYEMDFSDLEKKLVEPDVKLFILCNPHNPSGRSWSKE
HHHHHHHCCCCEEEECCCCCCCCCEECCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHH
ELTTLGELCLKHGVTVVSDEIHSDLMLNGLNHTPFASLSPEFADISITCIAPSKTFNLAG
HHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECC
LQASAIIIPDKAKRTAFAKVMQRQGLHSLNTFAIAAIEAAYSKGEPWLDQLIPYIERNME
CEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHH
EVRRFLAEELPEVRMMEPDASYLAWLDCRKLGLSDQDIKRLLLHKGKLILEPGPKYGPGG
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
EGFVRMNVGCSLSVVKDGLRRLKTAFS
CCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]