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The map label for this gene is ffh [H]

Identifier: 52785577

GI number: 52785577

Start: 1777385

End: 1778725

Strand: Direct

Name: ffh [H]

Synonym: BLi01818

Alternate gene names: 52785577

Gene position: 1777385-1778725 (Clockwise)

Preceding gene: 52785576

Following gene: 52785578

Centisome position: 42.09

GC content: 50.34

Gene sequence:

>1341_bases
ATGGCATTCGAAGGATTAGCCGACCGACTGCAGCAAACGATCTCAAAAATCCGCGGAAAAGGAAAGGTAACGGAGCAAGA
CGTCAAAGAGATGATGCGCGAAGTCCGTTTAGCGCTCCTTGAAGCGGACGTCAATTTTAAAGTCGTGAAAGATTTTGTGA
AAAAGGTAAGCGAACGAGCTGTCGGACAAGACGTTATGAAAAGCCTGACGCCCGGACAGCAGGTCATTAAAGTGGTAAAA
GAAGAGCTGACGGAGCTGATGGGCGGCGAGGAAAGCAAGATTGCCGCTGCAAAGCGTCCGCCGACCGTCATCATGATGGT
CGGTCTGCAAGGGGCCGGTAAAACGACGTCGACCGGAAAGCTTGCCAACCTGCTTCGCAAAAAACATAACCGCAATCCGC
TGCTCGTGGCAGCAGACATCTACCGCCCGGCGGCGATCAAACAGCTGGAAACGCTCGGCAAGCAGCTCGATATGCCGGTA
TTTTCACTGGGTGACAAGGTCAGTCCGGTGGAGATTGCCAAGCAGGCCATCGAAAAGGCGAAAGAAGATCATCACGACTA
CGTTCTCATCGATACGGCGGGACGCCTTCATATTGATGAAGAGCTGATGGATGAGCTTGAGCAGGTAAAAGAAACCGCTC
AGCCGGAAGAGATTTTCCTTGTCGTTGACTCCATGACGGGTCAAGACGCGGTCAATGTTGCCAAAAGCTTTAACGAACAG
CTCGGTGTGACAGGTGTCATCTTGACGAAGCTTGACGGCGATACTAGAGGCGGAGCGGCCTTGTCAATCCGCGCCGTGAC
AAACACGCCGATCAAATTCGCCGGAATGGGCGAAAAGCTTGATGCGCTGGAGCCGTTTCATCCTGAACGGATGGCTTCGC
GGATACTCGGAATGGGCGATGTGCTCACCCTTATCGAGAAAGCCCAGGCCAACGTAGACGAAGAAAAGGCGAAGGAACTC
GAGCAAAAAATGAAAAATATGAGCTTTACGCTCGACGACTTTTTGGAACAGCTCGGACAGGTCCGCAATATGGGGCCGCT
TGAAGACCTGATTCAAATGATGCCCGGCGCAGGCAAAATGAAAGGCTTAAAAAACGTGAAGGTTGATGAAAAACAGCTCA
GCCATATCGAAGCGATCATCAAGTCGATGACCGGGAAGGAAAAAGAGCAGCCTGAGATCATCAATGCAAGCAGGCGCAAA
CGGATTGCTAAAGGAAGCGGGACATCCGTCCAGGAAGTCAACCGTCTTTTAAAGCAATTTGAAGAAATGAAAAAAATGAT
GAAACAGATGACAAACATGACAAAAGGCAAGAAAAAAGGGTTTAAACTGCCCTTCATGTAA

Upstream 100 bases:

>100_bases
AAAGATTTTTGAAGCGCTGAGAAAGCTGACTGACGGTCAGCCTGAGGCGGAGTCCCTGATTGATGCGCTTGAGAAATTAG
ATTAGGAGGCGGCACTTAAT

Downstream 100 bases:

>100_bases
ACCTGTTTTCAGATGATAAAAACGTTGTTAAGAAAAAACACTTTACAAACACTTTTATCATTGTTAATATACTATCTTGT
TGAAATATTTTCGGAGGTGC

Product: hypothetical protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAFEGLADRLQQTISKIRGKGKVTEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVK
EELTELMGGEESKIAAAKRPPTVIMMVGLQGAGKTTSTGKLANLLRKKHNRNPLLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDKVSPVEIAKQAIEKAKEDHHDYVLIDTAGRLHIDEELMDELEQVKETAQPEEIFLVVDSMTGQDAVNVAKSFNEQ
LGVTGVILTKLDGDTRGGAALSIRAVTNTPIKFAGMGEKLDALEPFHPERMASRILGMGDVLTLIEKAQANVDEEKAKEL
EQKMKNMSFTLDDFLEQLGQVRNMGPLEDLIQMMPGAGKMKGLKNVKVDEKQLSHIEAIIKSMTGKEKEQPEIINASRRK
RIAKGSGTSVQEVNRLLKQFEEMKKMMKQMTNMTKGKKKGFKLPFM

Sequences:

>Translated_446_residues
MAFEGLADRLQQTISKIRGKGKVTEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVK
EELTELMGGEESKIAAAKRPPTVIMMVGLQGAGKTTSTGKLANLLRKKHNRNPLLVAADIYRPAAIKQLETLGKQLDMPV
FSLGDKVSPVEIAKQAIEKAKEDHHDYVLIDTAGRLHIDEELMDELEQVKETAQPEEIFLVVDSMTGQDAVNVAKSFNEQ
LGVTGVILTKLDGDTRGGAALSIRAVTNTPIKFAGMGEKLDALEPFHPERMASRILGMGDVLTLIEKAQANVDEEKAKEL
EQKMKNMSFTLDDFLEQLGQVRNMGPLEDLIQMMPGAGKMKGLKNVKVDEKQLSHIEAIIKSMTGKEKEQPEIINASRRK
RIAKGSGTSVQEVNRLLKQFEEMKKMMKQMTNMTKGKKKGFKLPFM
>Mature_445_residues
AFEGLADRLQQTISKIRGKGKVTEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVKE
ELTELMGGEESKIAAAKRPPTVIMMVGLQGAGKTTSTGKLANLLRKKHNRNPLLVAADIYRPAAIKQLETLGKQLDMPVF
SLGDKVSPVEIAKQAIEKAKEDHHDYVLIDTAGRLHIDEELMDELEQVKETAQPEEIFLVVDSMTGQDAVNVAKSFNEQL
GVTGVILTKLDGDTRGGAALSIRAVTNTPIKFAGMGEKLDALEPFHPERMASRILGMGDVLTLIEKAQANVDEEKAKELE
QKMKNMSFTLDDFLEQLGQVRNMGPLEDLIQMMPGAGKMKGLKNVKVDEKQLSHIEAIIKSMTGKEKEQPEIINASRRKR
IAKGSGTSVQEVNRLLKQFEEMKKMMKQMTNMTKGKKKGFKLPFM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=34.7345132743363, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI226371618, Length=371, Percent_Identity=35.5795148247978, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=41.5492957746479, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI23308697, Length=310, Percent_Identity=24.5161290322581, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI295424842, Length=310, Percent_Identity=24.5161290322581, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=54.7169811320755, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=33.8645418326693, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=441, Percent_Identity=30.6122448979592, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI193206261, Length=295, Percent_Identity=29.1525423728814, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=420, Percent_Identity=34.5238095238095, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=28.4810126582279, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17647949, Length=416, Percent_Identity=30.7692307692308, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24641198, Length=243, Percent_Identity=28.3950617283951, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49524; Mature: 49393

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLADRLQQTISKIRGKGKVTEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERA
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVIKVVKEELTELMGGEESKIAAAKRPPTVIMMVGLQGAGKTTSTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCCCHHH
LANLLRKKHNRNPLLVAADIYRPAAIKQLETLGKQLDMPVFSLGDKVSPVEIAKQAIEKA
HHHHHHHHCCCCCEEEECCHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEDHHDYVLIDTAGRLHIDEELMDELEQVKETAQPEEIFLVVDSMTGQDAVNVAKSFNEQ
HHCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
LGVTGVILTKLDGDTRGGAALSIRAVTNTPIKFAGMGEKLDALEPFHPERMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEECCCCCHHHCCCCCCHHHHHHHHHCCHH
VLTLIEKAQANVDEEKAKELEQKMKNMSFTLDDFLEQLGQVRNMGPLEDLIQMMPGAGKM
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KGLKNVKVDEKQLSHIEAIIKSMTGKEKEQPEIINASRRKRIAKGSGTSVQEVNRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHCCCCCCHHHHHHHHHHH
EEMKKMMKQMTNMTKGKKKGFKLPFM
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AFEGLADRLQQTISKIRGKGKVTEQDVKEMMREVRLALLEADVNFKVVKDFVKKVSERA
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGQDVMKSLTPGQQVIKVVKEELTELMGGEESKIAAAKRPPTVIMMVGLQGAGKTTSTGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCCCHHH
LANLLRKKHNRNPLLVAADIYRPAAIKQLETLGKQLDMPVFSLGDKVSPVEIAKQAIEKA
HHHHHHHHCCCCCEEEECCHHCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
KEDHHDYVLIDTAGRLHIDEELMDELEQVKETAQPEEIFLVVDSMTGQDAVNVAKSFNEQ
HHCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHH
LGVTGVILTKLDGDTRGGAALSIRAVTNTPIKFAGMGEKLDALEPFHPERMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEECCCCCHHHCCCCCCHHHHHHHHHCCHH
VLTLIEKAQANVDEEKAKELEQKMKNMSFTLDDFLEQLGQVRNMGPLEDLIQMMPGAGKM
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KGLKNVKVDEKQLSHIEAIIKSMTGKEKEQPEIINASRRKRIAKGSGTSVQEVNRLLKQF
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHCCCCCCHHHHHHHHHHH
EEMKKMMKQMTNMTKGKKKGFKLPFM
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]