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The map label for this gene is yloI [H]

Identifier: 52785550

GI number: 52785550

Start: 1748511

End: 1749728

Strand: Direct

Name: yloI [H]

Synonym: BLi01791

Alternate gene names: 52785550

Gene position: 1748511-1749728 (Clockwise)

Preceding gene: 52785549

Following gene: 52785551

Centisome position: 41.41

GC content: 52.79

Gene sequence:

>1218_bases
ATGCTGAAAAATCGCAACATCCTGCTGGGAGTAAGCGGAGGAATCGCGGTATACAAAGCGGCCGCCTTAACGAGCAAGCT
CGTGCAGGCAGGAGCCAATGTGAAAGTCATCATGACAAAATCCGCCTGTGAATTTGTGTCTCCGCTCACCTTTCAGGCGC
TTTCGCGCAATGAAGTATATACCAATACGTTCGAAGAACCGAATCCCCGTGTCATCGCCCATATCGATGCCGCAGATTGG
GCGGATCTCGTGATCGTTGCTCCGGCTACGGCCAATGTGATCGGAAAACTCGCCTCAGGCATCGCTGACGACATGCTGAC
GACGACGCTTTTGGCGACGACAGCGCCGGTGTGGATCGCTCCGGCGATGAACGTTCATATGTACGACCACCCGGCCGTTC
AGCGGAACATCAGCGTTCTTTACAAAGACGGCTACCGGTTTATCGAACCGAGTGAAGGCTACCTTGCGTGCGGCTATATC
GGCAAAGGCAGACTGGAAGAGCCTGAGCGGATCGTCCAGTTGGCAGAGTCGTATTTTTCAAGCGAAAAAAGCGGTTTGCT
TGAAGGAAAGCGCGTCGTAATTACAGCGGGGCCGACAAGAGAACAAGTCGATCCCGTCCGCTTTTTCTCCAACCGTTCGA
CAGGGAAAATGGGCTATGCTTTCGCTGAGGAAGCGGCACGAATGGGAGCGCACGTGACGCTGATTGCAGGCCCGACATCG
CTTGATGATCCCGCAGGGGTCGACGTGATTCATGTTCAGTCCGCAGAAGATATGTATCAAGCGGCTCTGTCTGTTTTCGA
TGAGAGCGACATCGTCATTAAAACAGCAGCTGTCGCTGATTACAGGCCAAAACATGTCCACGATCAAAAAATGAAGAAAA
AGGACGGCGGCCTCGTCATTGAGCTTGAACGGACGAAGGATATTTTAAAAGCGCTGGGAGAGCGGAAAACAAAGCAAATC
TTGGTCGGCTTTGCAGCCGAAACGCAGCACGTCGAAGACTATGCCAAACAAAAGCTGGAGACGAAAAATCTCGATATGAT
TGTCGCTAACAATATCACGGCTGAAGGCGCCGGTTTTGGAACGGAAACCAACATCGTGACGGTGTTTCATCGAGACTGCA
AAAAGACGGCGCATCCTCTAATGTCAAAGCGGGAGGTTGCCGCCGCAGTCTTGAAGGAAGCCGCTGAGCTTGCCGGACGG
AGCGGGACGTCTTCATGA

Upstream 100 bases:

>100_bases
CGAAAAGGAAAATCGCTAATAGCCTTAAAAATAGCAACCTATACACTAGGTTGTTATTTTTTTCAGGGCTGGCGAACAGA
ACATAAGGGGGAGAAATACG

Downstream 100 bases:

>100_bases
ACTTCGCTGAAGTGATCGTCGATGTTACAACGAAAAATATCGACAGACCGTTTGATTACCGCATCCCCGACAAATTCAAA
GGTATGATTAAAAAAGGGAT

Product: YloI

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLKNRNILLGVSGGIAVYKAAALTSKLVQAGANVKVIMTKSACEFVSPLTFQALSRNEVYTNTFEEPNPRVIAHIDAADW
ADLVIVAPATANVIGKLASGIADDMLTTTLLATTAPVWIAPAMNVHMYDHPAVQRNISVLYKDGYRFIEPSEGYLACGYI
GKGRLEEPERIVQLAESYFSSEKSGLLEGKRVVITAGPTREQVDPVRFFSNRSTGKMGYAFAEEAARMGAHVTLIAGPTS
LDDPAGVDVIHVQSAEDMYQAALSVFDESDIVIKTAAVADYRPKHVHDQKMKKKDGGLVIELERTKDILKALGERKTKQI
LVGFAAETQHVEDYAKQKLETKNLDMIVANNITAEGAGFGTETNIVTVFHRDCKKTAHPLMSKREVAAAVLKEAAELAGR
SGTSS

Sequences:

>Translated_405_residues
MLKNRNILLGVSGGIAVYKAAALTSKLVQAGANVKVIMTKSACEFVSPLTFQALSRNEVYTNTFEEPNPRVIAHIDAADW
ADLVIVAPATANVIGKLASGIADDMLTTTLLATTAPVWIAPAMNVHMYDHPAVQRNISVLYKDGYRFIEPSEGYLACGYI
GKGRLEEPERIVQLAESYFSSEKSGLLEGKRVVITAGPTREQVDPVRFFSNRSTGKMGYAFAEEAARMGAHVTLIAGPTS
LDDPAGVDVIHVQSAEDMYQAALSVFDESDIVIKTAAVADYRPKHVHDQKMKKKDGGLVIELERTKDILKALGERKTKQI
LVGFAAETQHVEDYAKQKLETKNLDMIVANNITAEGAGFGTETNIVTVFHRDCKKTAHPLMSKREVAAAVLKEAAELAGR
SGTSS
>Mature_405_residues
MLKNRNILLGVSGGIAVYKAAALTSKLVQAGANVKVIMTKSACEFVSPLTFQALSRNEVYTNTFEEPNPRVIAHIDAADW
ADLVIVAPATANVIGKLASGIADDMLTTTLLATTAPVWIAPAMNVHMYDHPAVQRNISVLYKDGYRFIEPSEGYLACGYI
GKGRLEEPERIVQLAESYFSSEKSGLLEGKRVVITAGPTREQVDPVRFFSNRSTGKMGYAFAEEAARMGAHVTLIAGPTS
LDDPAGVDVIHVQSAEDMYQAALSVFDESDIVIKTAAVADYRPKHVHDQKMKKKDGGLVIELERTKDILKALGERKTKQI
LVGFAAETQHVEDYAKQKLETKNLDMIVANNITAEGAGFGTETNIVTVFHRDCKKTAHPLMSKREVAAAVLKEAAELAGR
SGTSS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=175, Percent_Identity=34.8571428571429, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=42.6767676767677, Blast_Score=285, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=192, Percent_Identity=31.25, Blast_Score=88, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=31.25, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24657262, Length=194, Percent_Identity=32.9896907216495, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43867; Mature: 43867

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNRNILLGVSGGIAVYKAAALTSKLVQAGANVKVIMTKSACEFVSPLTFQALSRNEVY
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCHHHHHHCCCCCE
TNTFEEPNPRVIAHIDAADWADLVIVAPATANVIGKLASGIADDMLTTTLLATTAPVWIA
ECCCCCCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAMNVHMYDHPAVQRNISVLYKDGYRFIEPSEGYLACGYIGKGRLEEPERIVQLAESYFS
CCCEEEECCCCHHHHCEEEEEECCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
SEKSGLLEGKRVVITAGPTREQVDPVRFFSNRSTGKMGYAFAEEAARMGAHVTLIAGPTS
CCCCCCCCCCEEEEEECCCCHHCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCC
LDDPAGVDVIHVQSAEDMYQAALSVFDESDIVIKTAAVADYRPKHVHDQKMKKKDGGLVI
CCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCEEE
ELERTKDILKALGERKTKQILVGFAAETQHVEDYAKQKLETKNLDMIVANNITAEGAGFG
EEHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCEECCCCCC
TETNIVTVFHRDCKKTAHPLMSKREVAAAVLKEAAELAGRSGTSS
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKNRNILLGVSGGIAVYKAAALTSKLVQAGANVKVIMTKSACEFVSPLTFQALSRNEVY
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCHHHHHHCCCCCE
TNTFEEPNPRVIAHIDAADWADLVIVAPATANVIGKLASGIADDMLTTTLLATTAPVWIA
ECCCCCCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAMNVHMYDHPAVQRNISVLYKDGYRFIEPSEGYLACGYIGKGRLEEPERIVQLAESYFS
CCCEEEECCCCHHHHCEEEEEECCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
SEKSGLLEGKRVVITAGPTREQVDPVRFFSNRSTGKMGYAFAEEAARMGAHVTLIAGPTS
CCCCCCCCCCEEEEEECCCCHHCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCC
LDDPAGVDVIHVQSAEDMYQAALSVFDESDIVIKTAAVADYRPKHVHDQKMKKKDGGLVI
CCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCEEE
ELERTKDILKALGERKTKQILVGFAAETQHVEDYAKQKLETKNLDMIVANNITAEGAGFG
EEHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCEECCCCCC
TETNIVTVFHRDCKKTAHPLMSKREVAAAVLKEAAELAGRSGTSS
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]