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The map label for this gene is pyrD [H]

Identifier: 52785533

GI number: 52785533

Start: 1733159

End: 1734097

Strand: Direct

Name: pyrD [H]

Synonym: BLi01774

Alternate gene names: 52785533

Gene position: 1733159-1734097 (Clockwise)

Preceding gene: 52785532

Following gene: 52785534

Centisome position: 41.04

GC content: 54.63

Gene sequence:

>939_bases
ATGATGCTTGAAATCAATTTGCCGGGCCTTCAATTGAAAAATCCGATCATGCCGGCCTCAGGCTGCTTCGGATTCGGGAG
AGAATTTGCGAACTTTTACGATCTTTCGCGTCTCGGTGCGATCATGATTAAAGCGACGACGAGCGAGCCGCGCTTCGGGA
ATCCGACGCCGCGCGTCGCCGAGACGCAAGCCGGCATGCTTAATGCCATCGGCCTGCAAAATCCGGGTTTAAAGGCTGTC
ATGGAACGCGAATTGCCGTGGCTCGAACAGTTCGATACACCGATTATCGCCAATGTCGCCGGCTCGCAGATCGAGGATTA
TGTTGAGGTGGCTGAAGAAATCAGCAAAGCGCCAAACGTTCATGCGCTCGAGCTGAATATTTCCTGTCCCAATGTGAAAA
CCGGAGGCATCGCCTTCGGCACGCAGCCGGAAATGGCCGGCGAGCTGACGAAAGCGGTGAAAGAGGTTGCGAGCGTCCCC
GTCTATGTGAAGCTGTCGCCGAACGTCGCGAACATTACCGACATCGCTCTTGCCATAGAAGAAGCGGGAGCGGACGGTTT
GACGATGATCAACACGCTGATCGGGATGCGGCTCGACTTAAAAACGGGAAAGCCGATTTTGGCGAACAAAACCGGCGGAT
TATCAGGACCTGCCGTTAAACCGGTGGCCATCAGAATGGTGCATGAAGTCAGCCAAAAGGTCAGCATTCCGATCATCGGC
ATGGGCGGCGTCCAGTCAGCCGAAGATGTGCTTGAGTTTTTGCTGGCGGGTGCGAGCGCAGTCGCCGTCGGCACGGCAAA
CTTCGTTAATCCGTTTGCTTGTCCCGACATCATCGACGATTTGCCGCGCGTTTTAGAAAAATACGGATACCGTTCGTTGA
ACGAGTGTATCGGAAGGAGCTGGAAGGATGAACAATACGCCGCCCATCATCGCGCTTGA

Upstream 100 bases:

>100_bases
GCGCTTGCTTTGCCTGTGTCTGCCATACGGAAGAAAGCGAAACGTCTTATGTGAAGGTATGCCTTGACGGTCCTGTTTTC
AAAGCCCAGGAGGTGCTGTT

Downstream 100 bases:

>100_bases
TTTTGCATCAGCACAGGAAACATATGCGTTTTTGGACCGGTTTCAAGGAGAAGAGCTGTTCGTTAAGGTGGGCATGGAGC
TTTTTTATCAGGAAGGACCT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MMLEINLPGLQLKNPIMPASGCFGFGREFANFYDLSRLGAIMIKATTSEPRFGNPTPRVAETQAGMLNAIGLQNPGLKAV
MERELPWLEQFDTPIIANVAGSQIEDYVEVAEEISKAPNVHALELNISCPNVKTGGIAFGTQPEMAGELTKAVKEVASVP
VYVKLSPNVANITDIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVHEVSQKVSIPIIG
MGGVQSAEDVLEFLLAGASAVAVGTANFVNPFACPDIIDDLPRVLEKYGYRSLNECIGRSWKDEQYAAHHRA

Sequences:

>Translated_312_residues
MMLEINLPGLQLKNPIMPASGCFGFGREFANFYDLSRLGAIMIKATTSEPRFGNPTPRVAETQAGMLNAIGLQNPGLKAV
MERELPWLEQFDTPIIANVAGSQIEDYVEVAEEISKAPNVHALELNISCPNVKTGGIAFGTQPEMAGELTKAVKEVASVP
VYVKLSPNVANITDIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVHEVSQKVSIPIIG
MGGVQSAEDVLEFLLAGASAVAVGTANFVNPFACPDIIDDLPRVLEKYGYRSLNECIGRSWKDEQYAAHHRA
>Mature_312_residues
MMLEINLPGLQLKNPIMPASGCFGFGREFANFYDLSRLGAIMIKATTSEPRFGNPTPRVAETQAGMLNAIGLQNPGLKAV
MERELPWLEQFDTPIIANVAGSQIEDYVEVAEEISKAPNVHALELNISCPNVKTGGIAFGTQPEMAGELTKAVKEVASVP
VYVKLSPNVANITDIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVHEVSQKVSIPIIG
MGGVQSAEDVLEFLLAGASAVAVGTANFVNPFACPDIIDDLPRVLEKYGYRSLNECIGRSWKDEQYAAHHRA

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=258, Percent_Identity=32.9457364341085, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI45006951, Length=323, Percent_Identity=30.3405572755418, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI87082059, Length=324, Percent_Identity=29.9382716049383, Blast_Score=117, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=206, Percent_Identity=33.495145631068, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17509475, Length=329, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=299, Percent_Identity=29.4314381270903, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24640763, Length=230, Percent_Identity=31.304347826087, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI18858217, Length=230, Percent_Identity=31.304347826087, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI281361352, Length=324, Percent_Identity=31.1728395061728, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137316, Length=324, Percent_Identity=31.1728395061728, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33325; Mature: 33325

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLEINLPGLQLKNPIMPASGCFGFGREFANFYDLSRLGAIMIKATTSEPRFGNPTPRVA
CEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHH
ETQAGMLNAIGLQNPGLKAVMERELPWLEQFDTPIIANVAGSQIEDYVEVAEEISKAPNV
HHHCCHHHHCCCCCCCHHHHHHHCCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCE
HALELNISCPNVKTGGIAFGTQPEMAGELTKAVKEVASVPVYVKLSPNVANITDIALAIE
EEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
EAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVHEVSQKVSIPIIG
HCCCCHHHHHHHHHCCEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
MGGVQSAEDVLEFLLAGASAVAVGTANFVNPFACPDIIDDLPRVLEKYGYRSLNECIGRS
CCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
WKDEQYAAHHRA
CCCHHHHHHCCC
>Mature Secondary Structure
MMLEINLPGLQLKNPIMPASGCFGFGREFANFYDLSRLGAIMIKATTSEPRFGNPTPRVA
CEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHH
ETQAGMLNAIGLQNPGLKAVMERELPWLEQFDTPIIANVAGSQIEDYVEVAEEISKAPNV
HHHCCHHHHCCCCCCCHHHHHHHCCCHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCE
HALELNISCPNVKTGGIAFGTQPEMAGELTKAVKEVASVPVYVKLSPNVANITDIALAIE
EEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
EAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVAIRMVHEVSQKVSIPIIG
HCCCCHHHHHHHHHCCEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
MGGVQSAEDVLEFLLAGASAVAVGTANFVNPFACPDIIDDLPRVLEKYGYRSLNECIGRS
CCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
WKDEQYAAHHRA
CCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA