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The map label for this gene is yjcJ [H]

Identifier: 52785060

GI number: 52785060

Start: 1293443

End: 1294618

Strand: Direct

Name: yjcJ [H]

Synonym: BLi01290

Alternate gene names: 52785060

Gene position: 1293443-1294618 (Clockwise)

Preceding gene: 52785059

Following gene: 52785062

Centisome position: 30.63

GC content: 51.87

Gene sequence:

>1176_bases
ATGAGTCATGAAAACTGGACGCTTGAAACAAAGCTTGTTCATAACCAAAATAAAACGGACGGAGCAACCGGAGCCGTCAG
CGTGCCGATCCAGCACGCATCAACCTTTCATCAAGATTCTTTTGACAAATTCGGCGAATATGACTACAGCCGGTCAGGCA
CACCGACAAGGAAGGCGCTTGAAGACACGATAGCCGAGCTTGAGGGAGGGACGAGAGGATTTGCTTTTTCATCCGGCATG
GCTGCGATTTCCTCCGCCTTTCTGCTTTTGTCAAAGGGCGATCACGTGCTCGTCACAAAAGATGTGTACGGCGGCACTTA
CCGGATGATTACGGAAGTGCTGAGCCGCTTTGGGATTGAACATACTTTCGTCGATATGACGGATTTAAATGAAATTGCTT
TAAACATAAAGGAAAACACAAAAGTCATCTATCTTGAAACACCGTCAAATCCGACGCTCGGCATTACGGATATTAGAGGG
GTCGTCAAGCTTGCCAAGGCGCACGGCTGTCTGACGTTCCTTGACAACACGTTCATGACCCCGGCGTTGCAGCGACCGCT
TGAGCTCGGCGTCGATATTGTGCTTCACAGCGCGACGAAGTTTTTAAGCGGACACAGCGACGTATTATCAGGCCTTGCCG
TCGTGAAAGACAAAAAGCTCGGCGAAGAACTCTATAAGCTGCAAAATTCGTTCGGCGCTGTTCTCGGCGTCCAAGACTGC
TGGCTTGTGCTGAGAGGGCTGAAGACGCTCCAAGTGCGGCTTGAAAAAGCAAGCAGGACGGCTCAGCAGCTCGCCGAATT
TTTCGAAAAACATCCGGCCGTCAAACAAGTGTATTATCCAGGGCTGTCTTCGCATCCGGGTGCATCGATCCACAAACACC
AGGCGAACGGCGCAGGTGCGGTCCTTTCTTTTGAACTTGAGGATGCGGAAGCAGTCAAACAGGTTGTGGAAAATGTCTCT
CTCCCTGTCTTCGCCGTCAGTCTTGGAGCTGTGGAGTCGATCCTTTCTTATCCGGCAAAAATGTCGCACGCCGCCATGCC
GAAGGAGGAGCGCACAAAACGGGGCATTACCGACGGACTTCTGCGCTTGAGCGTCGGGGTCGAAAATGCCGATGATTTAC
AGGCGGACTTTGCCCAAGCGTTGGAAGCCGTATCCGGAGCGCTTGCCCGTTCATAA

Upstream 100 bases:

>100_bases
AACAGGCTTCTGCGCTTTTCAGTCGGAATCGAGCACGTCTCCGATTTGAAGCAGGATCTCAAAGCTGCACTGGAAAAAGT
GAAAGGGGAGGCGGTTCCGC

Downstream 100 bases:

>100_bases
AAGAAGGCGCGGATTCGTCAAGGAATCCGCGCCTTTTTTTGCCATTTATAACAGGGTGGAAAACCATGTGCCCAAGAAGG
TGCCGACATAATTGCCGATC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSHENWTLETKLVHNQNKTDGATGAVSVPIQHASTFHQDSFDKFGEYDYSRSGTPTRKALEDTIAELEGGTRGFAFSSGM
AAISSAFLLLSKGDHVLVTKDVYGGTYRMITEVLSRFGIEHTFVDMTDLNEIALNIKENTKVIYLETPSNPTLGITDIRG
VVKLAKAHGCLTFLDNTFMTPALQRPLELGVDIVLHSATKFLSGHSDVLSGLAVVKDKKLGEELYKLQNSFGAVLGVQDC
WLVLRGLKTLQVRLEKASRTAQQLAEFFEKHPAVKQVYYPGLSSHPGASIHKHQANGAGAVLSFELEDAEAVKQVVENVS
LPVFAVSLGAVESILSYPAKMSHAAMPKEERTKRGITDGLLRLSVGVENADDLQADFAQALEAVSGALARS

Sequences:

>Translated_391_residues
MSHENWTLETKLVHNQNKTDGATGAVSVPIQHASTFHQDSFDKFGEYDYSRSGTPTRKALEDTIAELEGGTRGFAFSSGM
AAISSAFLLLSKGDHVLVTKDVYGGTYRMITEVLSRFGIEHTFVDMTDLNEIALNIKENTKVIYLETPSNPTLGITDIRG
VVKLAKAHGCLTFLDNTFMTPALQRPLELGVDIVLHSATKFLSGHSDVLSGLAVVKDKKLGEELYKLQNSFGAVLGVQDC
WLVLRGLKTLQVRLEKASRTAQQLAEFFEKHPAVKQVYYPGLSSHPGASIHKHQANGAGAVLSFELEDAEAVKQVVENVS
LPVFAVSLGAVESILSYPAKMSHAAMPKEERTKRGITDGLLRLSVGVENADDLQADFAQALEAVSGALARS
>Mature_390_residues
SHENWTLETKLVHNQNKTDGATGAVSVPIQHASTFHQDSFDKFGEYDYSRSGTPTRKALEDTIAELEGGTRGFAFSSGMA
AISSAFLLLSKGDHVLVTKDVYGGTYRMITEVLSRFGIEHTFVDMTDLNEIALNIKENTKVIYLETPSNPTLGITDIRGV
VKLAKAHGCLTFLDNTFMTPALQRPLELGVDIVLHSATKFLSGHSDVLSGLAVVKDKKLGEELYKLQNSFGAVLGVQDCW
LVLRGLKTLQVRLEKASRTAQQLAEFFEKHPAVKQVYYPGLSSHPGASIHKHQANGAGAVLSFELEDAEAVKQVVENVSL
PVFAVSLGAVESILSYPAKMSHAAMPKEERTKRGITDGLLRLSVGVENADDLQADFAQALEAVSGALARS

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=377, Percent_Identity=41.9098143236074, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI299473759, Length=377, Percent_Identity=37.9310344827586, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI25453487, Length=376, Percent_Identity=37.7659574468085, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1790375, Length=368, Percent_Identity=40.2173913043478, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789383, Length=386, Percent_Identity=31.0880829015544, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=362, Percent_Identity=43.0939226519337, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71980708, Length=390, Percent_Identity=38.974358974359, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17538055, Length=361, Percent_Identity=41.8282548476454, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI193202265, Length=107, Percent_Identity=35.5140186915888, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319307, Length=389, Percent_Identity=41.6452442159383, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=35.4838709677419, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323333, Length=425, Percent_Identity=32.9411764705882, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6321170, Length=323, Percent_Identity=33.4365325077399, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=401, Percent_Identity=31.1720698254364, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322970, Length=350, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322590, Length=368, Percent_Identity=23.9130434782609, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323557, Length=343, Percent_Identity=23.9067055393586, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922554, Length=387, Percent_Identity=42.8940568475452, Blast_Score=302, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42402; Mature: 42270

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHENWTLETKLVHNQNKTDGATGAVSVPIQHASTFHQDSFDKFGEYDYSRSGTPTRKAL
CCCCCEEEEEEEECCCCCCCCCCCEEEECHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHH
EDTIAELEGGTRGFAFSSGMAAISSAFLLLSKGDHVLVTKDVYGGTYRMITEVLSRFGIE
HHHHHHHCCCCCCCCHHCCHHHHHHHHHEEECCCEEEEEECCCCCHHHHHHHHHHHHCCC
HTFVDMTDLNEIALNIKENTKVIYLETPSNPTLGITDIRGVVKLAKAHGCLTFLDNTFMT
EEEEECCCCCHHEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCC
PALQRPLELGVDIVLHSATKFLSGHSDVLSGLAVVKDKKLGEELYKLQNSFGAVLGVQDC
HHHHCHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVLRGLKTLQVRLEKASRTAQQLAEFFEKHPAVKQVYYPGLSSHPGASIHKHQANGAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCE
VLSFELEDAEAVKQVVENVSLPVFAVSLGAVESILSYPAKMSHAAMPKEERTKRGITDGL
EEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHCCHHHHH
LRLSVGVENADDLQADFAQALEAVSGALARS
HEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHENWTLETKLVHNQNKTDGATGAVSVPIQHASTFHQDSFDKFGEYDYSRSGTPTRKAL
CCCCEEEEEEEECCCCCCCCCCCEEEECHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHH
EDTIAELEGGTRGFAFSSGMAAISSAFLLLSKGDHVLVTKDVYGGTYRMITEVLSRFGIE
HHHHHHHCCCCCCCCHHCCHHHHHHHHHEEECCCEEEEEECCCCCHHHHHHHHHHHHCCC
HTFVDMTDLNEIALNIKENTKVIYLETPSNPTLGITDIRGVVKLAKAHGCLTFLDNTFMT
EEEEECCCCCHHEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCC
PALQRPLELGVDIVLHSATKFLSGHSDVLSGLAVVKDKKLGEELYKLQNSFGAVLGVQDC
HHHHCHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVLRGLKTLQVRLEKASRTAQQLAEFFEKHPAVKQVYYPGLSSHPGASIHKHQANGAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCE
VLSFELEDAEAVKQVVENVSLPVFAVSLGAVESILSYPAKMSHAAMPKEERTKRGITDGL
EEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHCCHHHHH
LRLSVGVENADDLQADFAQALEAVSGALARS
HEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]