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The map label for this gene is yjcI [H]

Identifier: 52785059

GI number: 52785059

Start: 1292290

End: 1293453

Strand: Direct

Name: yjcI [H]

Synonym: BLi01289

Alternate gene names: 52785059

Gene position: 1292290-1293453 (Clockwise)

Preceding gene: 52785046

Following gene: 52785060

Centisome position: 30.6

GC content: 48.63

Gene sequence:

>1164_bases
ATGAAGAAGGGGTTTTTACTTTTTAAAGGATGGTGTCATATGACTGAACATGTACAAACAACGCTGGCGCAAATCGGCAA
CCGCAGTGACGAAATAACCGGAACCGTCAATCCTCCCGTTTATTTCTCTTCTGCGTACAGGCACAAAGGAATCGGGGAAT
CCACAGGATTTGATTACATTCGCACAAAAAATCCGACAAGACAGCTTGTAGAAGATGCAATCGCGAAACTAGAAGGGGGA
ACGCGCGGCTTTGCGTTCAGTTCTGGTATGGCTGCCATTCAGACGATCATGGCTCTGTTTCAAAGCGGGGATGAGCTCAT
CGTTTCATCCGATTTATACGGGGGAACATACCGCCTTTTTGAAAACGAATGGAAGAAATACGGACTGCGCTTTTTATACG
ATGATTTTTCAGACGAAGACTGTATCAAGTCGAAAATCACGGACAATACGAAGGCACTGTTTGTAGAAACGCCGACAAAT
CCGCTCATGCAGGAAGCAGACATTCAAAAAATTGCGCAAATCGCCAAAGAGAACGACTTGCTGCTCATTGTCGACAATAC
GTTTTATACACCGGTTCTGCAAAGGCCGATTGAGCTAGGCGCTGATCTTGTCATTCACAGCGCGACGAAGTATTTGGGCG
GTCATAACGATCTTTTGGCGGGGCTTGTCGTCGCAAAAGGCGAAGAGCTGTCTGAGGAAATGTTCCAGCACCAAAATGCC
ATCGGCGCGGTTTTATCGCCGTTCGATTCGTGGCTCTTAATGAGAGGGTTGAAGACGCTCGCTCTTAGGATGAGACAGCA
TCAGGAAAACGCGCGGGAGCTCGCGGCCTTTTTGGAAGAGCAGGAGGAAATTGCCGATGTTCTTTATCCGGGAAAAGGCG
GCATGCTGTCATTCCGCGTTCAAAAAGAAGAATGGGTCAATCCGTTTCTAAAAAATCTCAAGACGATCTGTTTCGCCGAA
AGCCTCGGCGGAGTCGAAAGCTTCATCACCTACCCGGCGACACAGACCCACATGGATATCCCGGAAGACATCCGAATTGC
AAACGGCGTCTGCAACAGGCTTCTGCGCTTTTCAGTCGGAATCGAGCACGTCTCCGATTTGAAGCAGGATCTCAAAGCTG
CACTGGAAAAAGTGAAAGGGGAGGCGGTTCCGCATGAGTCATGA

Upstream 100 bases:

>100_bases
AGCAACCGGTCTGCACTGACGACGTCAGTGCACCAAGGTGCTAAATCCAGCAAGCGGATGCTTGGAAGATAAGAAGAAGC
GAATAATCCCCCTTCTTCTT

Downstream 100 bases:

>100_bases
AAACTGGACGCTTGAAACAAAGCTTGTTCATAACCAAAATAAAACGGACGGAGCAACCGGAGCCGTCAGCGTGCCGATCC
AGCACGCATCAACCTTTCAT

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKKGFLLFKGWCHMTEHVQTTLAQIGNRSDEITGTVNPPVYFSSAYRHKGIGESTGFDYIRTKNPTRQLVEDAIAKLEGG
TRGFAFSSGMAAIQTIMALFQSGDELIVSSDLYGGTYRLFENEWKKYGLRFLYDDFSDEDCIKSKITDNTKALFVETPTN
PLMQEADIQKIAQIAKENDLLLIVDNTFYTPVLQRPIELGADLVIHSATKYLGGHNDLLAGLVVAKGEELSEEMFQHQNA
IGAVLSPFDSWLLMRGLKTLALRMRQHQENARELAAFLEEQEEIADVLYPGKGGMLSFRVQKEEWVNPFLKNLKTICFAE
SLGGVESFITYPATQTHMDIPEDIRIANGVCNRLLRFSVGIEHVSDLKQDLKAALEKVKGEAVPHES

Sequences:

>Translated_387_residues
MKKGFLLFKGWCHMTEHVQTTLAQIGNRSDEITGTVNPPVYFSSAYRHKGIGESTGFDYIRTKNPTRQLVEDAIAKLEGG
TRGFAFSSGMAAIQTIMALFQSGDELIVSSDLYGGTYRLFENEWKKYGLRFLYDDFSDEDCIKSKITDNTKALFVETPTN
PLMQEADIQKIAQIAKENDLLLIVDNTFYTPVLQRPIELGADLVIHSATKYLGGHNDLLAGLVVAKGEELSEEMFQHQNA
IGAVLSPFDSWLLMRGLKTLALRMRQHQENARELAAFLEEQEEIADVLYPGKGGMLSFRVQKEEWVNPFLKNLKTICFAE
SLGGVESFITYPATQTHMDIPEDIRIANGVCNRLLRFSVGIEHVSDLKQDLKAALEKVKGEAVPHES
>Mature_387_residues
MKKGFLLFKGWCHMTEHVQTTLAQIGNRSDEITGTVNPPVYFSSAYRHKGIGESTGFDYIRTKNPTRQLVEDAIAKLEGG
TRGFAFSSGMAAIQTIMALFQSGDELIVSSDLYGGTYRLFENEWKKYGLRFLYDDFSDEDCIKSKITDNTKALFVETPTN
PLMQEADIQKIAQIAKENDLLLIVDNTFYTPVLQRPIELGADLVIHSATKYLGGHNDLLAGLVVAKGEELSEEMFQHQNA
IGAVLSPFDSWLLMRGLKTLALRMRQHQENARELAAFLEEQEEIADVLYPGKGGMLSFRVQKEEWVNPFLKNLKTICFAE
SLGGVESFITYPATQTHMDIPEDIRIANGVCNRLLRFSVGIEHVSDLKQDLKAALEKVKGEAVPHES

Specific function: Catalyzes the transformation of O-succinylhomoserine into cystathionine, as well as O-acetylhomoserine and sulfide into homocysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=371, Percent_Identity=38.8140161725067, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI299473759, Length=371, Percent_Identity=34.5013477088949, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI25453487, Length=370, Percent_Identity=33.5135135135135, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=40.5835543766578, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=27.5689223057644, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17538055, Length=387, Percent_Identity=40.3100775193798, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=39.2370572207085, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71980708, Length=395, Percent_Identity=34.4303797468354, Blast_Score=217, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6319307, Length=374, Percent_Identity=39.3048128342246, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=32.3383084577114, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323333, Length=442, Percent_Identity=31.447963800905, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321170, Length=277, Percent_Identity=32.4909747292419, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321904, Length=388, Percent_Identity=28.6082474226804, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922554, Length=363, Percent_Identity=40.495867768595, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48; =2.5.1.49 [H]

Molecular weight: Translated: 43351; Mature: 43351

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGFLLFKGWCHMTEHVQTTLAQIGNRSDEITGTVNPPVYFSSAYRHKGIGESTGFDYI
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEECCHHHHCCCCCCCCCCCC
RTKNPTRQLVEDAIAKLEGGTRGFAFSSGMAAIQTIMALFQSGDELIVSSDLYGGTYRLF
CCCCHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHH
ENEWKKYGLRFLYDDFSDEDCIKSKITDNTKALFVETPTNPLMQEADIQKIAQIAKENDL
HHHHHHHCCHHEECCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCE
LLIVDNTFYTPVLQRPIELGADLVIHSATKYLGGHNDLLAGLVVAKGEELSEEMFQHQNA
EEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
IGAVLSPFDSWLLMRGLKTLALRMRQHQENARELAAFLEEQEEIADVLYPGKGGMLSFRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
QKEEWVNPFLKNLKTICFAESLGGVESFITYPATQTHMDIPEDIRIANGVCNRLLRFSVG
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IEHVSDLKQDLKAALEKVKGEAVPHES
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKGFLLFKGWCHMTEHVQTTLAQIGNRSDEITGTVNPPVYFSSAYRHKGIGESTGFDYI
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEECCHHHHCCCCCCCCCCCC
RTKNPTRQLVEDAIAKLEGGTRGFAFSSGMAAIQTIMALFQSGDELIVSSDLYGGTYRLF
CCCCHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHH
ENEWKKYGLRFLYDDFSDEDCIKSKITDNTKALFVETPTNPLMQEADIQKIAQIAKENDL
HHHHHHHCCHHEECCCCCHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCE
LLIVDNTFYTPVLQRPIELGADLVIHSATKYLGGHNDLLAGLVVAKGEELSEEMFQHQNA
EEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
IGAVLSPFDSWLLMRGLKTLALRMRQHQENARELAAFLEEQEEIADVLYPGKGGMLSFRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
QKEEWVNPFLKNLKTICFAESLGGVESFITYPATQTHMDIPEDIRIANGVCNRLLRFSVG
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IEHVSDLKQDLKAALEKVKGEAVPHES
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]