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The map label for this gene is appC [H]

Identifier: 52785000

GI number: 52785000

Start: 1238820

End: 1239734

Strand: Direct

Name: appC [H]

Synonym: BLi01228

Alternate gene names: 52785000

Gene position: 1238820-1239734 (Clockwise)

Preceding gene: 52784999

Following gene: 52785001

Centisome position: 29.34

GC content: 47.32

Gene sequence:

>915_bases
ATGACACAGACAAATCCATCGACACCTTCGCCGGAGATCACATTGCAGGAAAATGTCGCACCAAAGCCCGAGACAATGAC
AAAAATCTTTTTTGAAAAGTTTTATAAAAACAAGCTGGCGGTAATTGGAGGAGTTTTATTATTTATTATTATCCTATCAG
CGATTTTTGCTCCGGTGATCGCTCCATACCCGCCGGAACAGCAAAACCTTCTGAATAAGCTAAAACCGCCAAGTGGTGAA
CATCTAATGGGAACAGACAAGTTTGGCCGAGATATTTTCAGCCGTTTACTTTATGGGGCTCGGGTTTCTTTACTTGTAGG
CTTTGCCTCTGTACTTGGATCGATTACGATAGGTACGGTGGTCGGCGCAATCGCCGGCTACTTTGGCGGAATAATCGACG
CTATTATGATGAGACTGGTGGATATTGTATTATCCATACCCGACATCTTTCTGTTAATCACGCTGGTCACCATCTTCCAG
CCGGGCATAGATAAACTGATTTTAATATTCGCCTTGACGAGATGGACGACGACAGCGCGCCTTGTCCGGAGCGAGTTTTT
GTCCTTGAGGTCGAGGGAGTTCGTCTTGGCGGCGAAAACGATCGGTACAAGAAATTACAAAATCATTTTTTCTCATATCC
TTCCGAATGCGATGGGGCCGATTATCGTTGCCGCGACGCTTTCCGTCGGTACCGTAATCCTTGCGGAATCGGCATTAAGC
TATCTTGGATTCGGGGTTCAGCCGCCGATGGCAAGCTGGGGAAACATGCTTCAGGATGCACAGAACTTTACGATCATGAT
CCAGGCGTGGTGGTATCCGCTGTTCCCGGGCCTGATGATCCTGCTCACTGTGCTGTGCTTTAACTTCTTAGGCGACGGAC
TCCGCGATGCGCTTGATCCGAAGAATATTAAATGA

Upstream 100 bases:

>100_bases
ATTTCAGCCACACTTGTTGTCATTGGGAATTTAGTTGCGGATATTCTTTATGCAATGGTCGATCCGCGGATTGAGTATTA
ATGAAGGAGGGAATTGATTC

Downstream 100 bases:

>100_bases
TTTATGCAGTGTATTACAGAGGAAATATTTTAACAAAATGGAAGGTCAATAGATTTAGTTTCAATGAATGTATGTAGTGG
ACATTGAACGAATGTTTCCT

Product: AppC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTQTNPSTPSPEITLQENVAPKPETMTKIFFEKFYKNKLAVIGGVLLFIIILSAIFAPVIAPYPPEQQNLLNKLKPPSGE
HLMGTDKFGRDIFSRLLYGARVSLLVGFASVLGSITIGTVVGAIAGYFGGIIDAIMMRLVDIVLSIPDIFLLITLVTIFQ
PGIDKLILIFALTRWTTTARLVRSEFLSLRSREFVLAAKTIGTRNYKIIFSHILPNAMGPIIVAATLSVGTVILAESALS
YLGFGVQPPMASWGNMLQDAQNFTIMIQAWWYPLFPGLMILLTVLCFNFLGDGLRDALDPKNIK

Sequences:

>Translated_304_residues
MTQTNPSTPSPEITLQENVAPKPETMTKIFFEKFYKNKLAVIGGVLLFIIILSAIFAPVIAPYPPEQQNLLNKLKPPSGE
HLMGTDKFGRDIFSRLLYGARVSLLVGFASVLGSITIGTVVGAIAGYFGGIIDAIMMRLVDIVLSIPDIFLLITLVTIFQ
PGIDKLILIFALTRWTTTARLVRSEFLSLRSREFVLAAKTIGTRNYKIIFSHILPNAMGPIIVAATLSVGTVILAESALS
YLGFGVQPPMASWGNMLQDAQNFTIMIQAWWYPLFPGLMILLTVLCFNFLGDGLRDALDPKNIK
>Mature_303_residues
TQTNPSTPSPEITLQENVAPKPETMTKIFFEKFYKNKLAVIGGVLLFIIILSAIFAPVIAPYPPEQQNLLNKLKPPSGEH
LMGTDKFGRDIFSRLLYGARVSLLVGFASVLGSITIGTVVGAIAGYFGGIIDAIMMRLVDIVLSIPDIFLLITLVTIFQP
GIDKLILIFALTRWTTTARLVRSEFLSLRSREFVLAAKTIGTRNYKIIFSHILPNAMGPIIVAATLSVGTVILAESALSY
LGFGVQPPMASWGNMLQDAQNFTIMIQAWWYPLFPGLMILLTVLCFNFLGDGLRDALDPKNIK

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787760, Length=290, Percent_Identity=38.9655172413793, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1787054, Length=273, Percent_Identity=41.025641025641, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1789964, Length=288, Percent_Identity=46.1805555555556, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1787498, Length=292, Percent_Identity=39.3835616438356, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789889, Length=243, Percent_Identity=39.0946502057613, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1788505, Length=230, Percent_Identity=34.7826086956522, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1787549, Length=283, Percent_Identity=31.4487632508834, Blast_Score=130, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33394; Mature: 33263

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTNPSTPSPEITLQENVAPKPETMTKIFFEKFYKNKLAVIGGVLLFIIILSAIFAPVI
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APYPPEQQNLLNKLKPPSGEHLMGTDKFGRDIFSRLLYGARVSLLVGFASVLGSITIGTV
CCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAIAGYFGGIIDAIMMRLVDIVLSIPDIFLLITLVTIFQPGIDKLILIFALTRWTTTAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LVRSEFLSLRSREFVLAAKTIGTRNYKIIFSHILPNAMGPIIVAATLSVGTVILAESALS
HHHHHHHHHHCCHHEEEHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLGFGVQPPMASWGNMLQDAQNFTIMIQAWWYPLFPGLMILLTVLCFNFLGDGLRDALDP
HHCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KNIK
CCCC
>Mature Secondary Structure 
TQTNPSTPSPEITLQENVAPKPETMTKIFFEKFYKNKLAVIGGVLLFIIILSAIFAPVI
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]