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The map label for this gene is degA [H]

Identifier: 52784952

GI number: 52784952

Start: 1187966

End: 1189009

Strand: Direct

Name: degA [H]

Synonym: BLi01180

Alternate gene names: 52784952

Gene position: 1187966-1189009 (Clockwise)

Preceding gene: 52784951

Following gene: 52784953

Centisome position: 28.13

GC content: 51.63

Gene sequence:

>1044_bases
ATGAAAAAAACCATTTATGATGTAGCGGAAGCGGCCGGCGTTTCGATTTCCACGGTTTCCCGGGTGATCAACAATACCGG
GAGGATCAGCAGGTCGACAAGGCAAAGAGTGCATGCCGTCATGAAAGAGCTCGATTACCAGCCGAATGTTCACGCTTCTG
CGCTTACCGGAAAGCGCACGAACATTATCGGCCTGTTGACGCCCGATATTGCAAACCCGTTTTTCGGCGAGCTTGCCAAA
AGTGTTGAAGAGCGGGCGGGCGAGCTCGGCTTCAGCATTATGATGTGCAGTACCGACCGCGATCCGAAAAAGGAGACAAC
GTATTTCTCGGTCCTCAAGCAAAAAAGCGTCGACGGCATCATTTTTGCGACAGGCATCGAAAATCAGGAGACGATGGATG
CGCTCGAGGATATTGCCAAAGAGGGCATACCGCTCGTGATGATTTCCCAGGATCGCGCCCTTGTTCCGATGGATGTCGTG
GTCATCGATGATTTTATGGGCGGATATTTAGCGACGCGGCATTTAATTTCGCTCGGTCATAAGACAATCGCCTGCATCGC
CGGCGACGGATCGACAACCGGAGAAAAAGACAGGCTGAAAGGCTTCAAAAAAGCGATGGATGAAGCAGGCATCAAAGCGG
ATGAAACGCTCATCGCCGGATCCGGTTTTTCCCTGGAATGCGGCAAAAAAGCGGCCGCTCAGATTTTCAAAAGCAATATT
CCGACCGCCGTTTTTGCCATGAATGATGTGCTCGCGTGCGGAGTCATTCAGACTGCAAGGGAATGGGGGCTCCATGTTCC
AACGGATTTATCGGTCATCGGCTTTGATAATACGTTTTTAGCCGAAATGACCGATCCGCCGCTTACGACAGTGTCTCAGC
CGATTGAAGAAATGGGCCGCCGCGCGGCCGAGCTGCTTGCCGAAGAAATCAGCGGCAAGAAAAGCTCGAAAAGCAAAATC
ATTCTCACGCCTGAACTTGTCGTCAGACAGTCGACGGCCCCTCCATTTAAAAAAGAAGCACATGCCGAAAAGAGCGGGTT
TTGA

Upstream 100 bases:

>100_bases
GAATCCTGCGGGAGGAGTGGGAGCTGATTTGCCGCGGAAGCTGACACGCTCTATAATATAATATTAGAAATCTTTCATCA
GCGGACTAGAGGGGACCAAT

Downstream 100 bases:

>100_bases
TAGAAAAACGCTCTTTTTTCGTTTCTAAAGAGCAAGCGCTTGACCAAATTAATTCCTAAAAAACAATTGCGGATAAAATA
AATACAGGGTAAAATCAGAA

Product: DegA

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKKTIYDVAEAAGVSISTVSRVINNTGRISRSTRQRVHAVMKELDYQPNVHASALTGKRTNIIGLLTPDIANPFFGELAK
SVEERAGELGFSIMMCSTDRDPKKETTYFSVLKQKSVDGIIFATGIENQETMDALEDIAKEGIPLVMISQDRALVPMDVV
VIDDFMGGYLATRHLISLGHKTIACIAGDGSTTGEKDRLKGFKKAMDEAGIKADETLIAGSGFSLECGKKAAAQIFKSNI
PTAVFAMNDVLACGVIQTAREWGLHVPTDLSVIGFDNTFLAEMTDPPLTTVSQPIEEMGRRAAELLAEEISGKKSSKSKI
ILTPELVVRQSTAPPFKKEAHAEKSGF

Sequences:

>Translated_347_residues
MKKTIYDVAEAAGVSISTVSRVINNTGRISRSTRQRVHAVMKELDYQPNVHASALTGKRTNIIGLLTPDIANPFFGELAK
SVEERAGELGFSIMMCSTDRDPKKETTYFSVLKQKSVDGIIFATGIENQETMDALEDIAKEGIPLVMISQDRALVPMDVV
VIDDFMGGYLATRHLISLGHKTIACIAGDGSTTGEKDRLKGFKKAMDEAGIKADETLIAGSGFSLECGKKAAAQIFKSNI
PTAVFAMNDVLACGVIQTAREWGLHVPTDLSVIGFDNTFLAEMTDPPLTTVSQPIEEMGRRAAELLAEEISGKKSSKSKI
ILTPELVVRQSTAPPFKKEAHAEKSGF
>Mature_347_residues
MKKTIYDVAEAAGVSISTVSRVINNTGRISRSTRQRVHAVMKELDYQPNVHASALTGKRTNIIGLLTPDIANPFFGELAK
SVEERAGELGFSIMMCSTDRDPKKETTYFSVLKQKSVDGIIFATGIENQETMDALEDIAKEGIPLVMISQDRALVPMDVV
VIDDFMGGYLATRHLISLGHKTIACIAGDGSTTGEKDRLKGFKKAMDEAGIKADETLIAGSGFSLECGKKAAAQIFKSNI
PTAVFAMNDVLACGVIQTAREWGLHVPTDLSVIGFDNTFLAEMTDPPLTTVSQPIEEMGRRAAELLAEEISGKKSSKSKI
ILTPELVVRQSTAPPFKKEAHAEKSGF

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=337, Percent_Identity=37.0919881305638, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1790369, Length=337, Percent_Identity=33.8278931750742, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=36.5558912386707, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1789202, Length=344, Percent_Identity=32.2674418604651, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1788474, Length=332, Percent_Identity=32.2289156626506, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1787580, Length=330, Percent_Identity=31.8181818181818, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=31.1953352769679, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787906, Length=344, Percent_Identity=30.5232558139535, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789068, Length=335, Percent_Identity=28.3582089552239, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI48994940, Length=317, Percent_Identity=28.7066246056782, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1786268, Length=321, Percent_Identity=26.1682242990654, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790715, Length=334, Percent_Identity=24.251497005988, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790689, Length=326, Percent_Identity=25.7668711656442, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37513; Mature: 37513

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2 ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTIYDVAEAAGVSISTVSRVINNTGRISRSTRQRVHAVMKELDYQPNVHASALTGKRT
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCC
NIIGLLTPDIANPFFGELAKSVEERAGELGFSIMMCSTDRDPKKETTYFSVLKQKSVDGI
CEEEEECCHHCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
IFATGIENQETMDALEDIAKEGIPLVMISQDRALVPMDVVVIDDFMGGYLATRHLISLGH
EEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCC
KTIACIAGDGSTTGEKDRLKGFKKAMDEAGIKADETLIAGSGFSLECGKKAAAQIFKSNI
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCC
PTAVFAMNDVLACGVIQTAREWGLHVPTDLSVIGFDNTFLAEMTDPPLTTVSQPIEEMGR
CEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHH
RAAELLAEEISGKKSSKSKIILTPELVVRQSTAPPFKKEAHAEKSGF
HHHHHHHHHHCCCCCCCCEEEECHHHHEECCCCCCHHHHHCHHCCCC
>Mature Secondary Structure
MKKTIYDVAEAAGVSISTVSRVINNTGRISRSTRQRVHAVMKELDYQPNVHASALTGKRT
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCC
NIIGLLTPDIANPFFGELAKSVEERAGELGFSIMMCSTDRDPKKETTYFSVLKQKSVDGI
CEEEEECCHHCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
IFATGIENQETMDALEDIAKEGIPLVMISQDRALVPMDVVVIDDFMGGYLATRHLISLGH
EEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCC
KTIACIAGDGSTTGEKDRLKGFKKAMDEAGIKADETLIAGSGFSLECGKKAAAQIFKSNI
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCC
PTAVFAMNDVLACGVIQTAREWGLHVPTDLSVIGFDNTFLAEMTDPPLTTVSQPIEEMGR
CEEEHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHH
RAAELLAEEISGKKSSKSKIILTPELVVRQSTAPPFKKEAHAEKSGF
HHHHHHHHHHCCCCCCCCEEEECHHHHEECCCCCCHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]