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The map label for this gene is msmR [H]

Identifier: 52784911

GI number: 52784911

Start: 1144778

End: 1145821

Strand: Direct

Name: msmR [H]

Synonym: BLi01139

Alternate gene names: 52784911

Gene position: 1144778-1145821 (Clockwise)

Preceding gene: 52784909

Following gene: 52784912

Centisome position: 27.11

GC content: 50.0

Gene sequence:

>1044_bases
ATGAAAATGGCGACGATTAAAGAGATTGCGCTTCAGGCTAAAGTATCAAGCACAACGGTTTCAAGGGTTCTGAACCATGA
CCAGTCATTATCAGTAGCGCCTGAAACAAGGCAGCGGATTTTGGATATAGCAGCCCGGCTCGGCTATAAAAGCACGCGCA
GGCGCCGCGAGGTATATGCCTCAGGAAGCGGGGAAAGCCCGCGCATCGGCATTGTTGTCTGCCAATCACAGGAAGAAGAG
CTGAACGATCCGTACTTTTATTCCATCAGGCAGGGAATTGAAAGTGAGTGTTTTGAAAGAGGAGCGTTTATTACGAAATT
TATTCAGCTGAGCAGCATCCGCTCGAATCAGCCTGTAGGCGATGTCGACGGCTTAATCGTCATCGGAAGGATCAACTTTG
CCGGTTTGCAGCAGTGCATGGGCGCGCTCAACAACGTCGTGTACATCAACCATACAGACAATGAAGAGCTGCGCGACTCG
GTTGTCGTAGATTTTGAGAAGGCTACGGGGAGGGCGCTGAACCATTTGAAATCGCTCGGCTATACAAGGATCGGTTATAT
CGGCGGAAGAGAAAAAGAGCACTTTCGAATCAGCGATCAGGAGACAAGCGCCATTGAAATCGAAGACAAACGTCTGACTG
CGTTTCTGGAGATGGCCGGTTCGGATAACGCAAAGCACATTTATATCGGCGAGTATTCGATGCAGCAAGGCTATGAACTG
ATGAAAAAAGCGCTTTTAGAGAAAAACGTTCCCGAAGCTTTTTTTATCGCCAGCGATTCAATGGCCATCGGCGCGCTCCG
GGCGCTTCGAGAATCGGGACTCAAGGTTCCCGAAGATGTTGCAATCGTCAGCTTCAACGGCATTGAAGCGTCCGAATTTG
CTAATCCGCCATTGACAACCGTAAAGGTTCATACAGAAGAGATGGGCCGGACGGGTGTGAAGCTGCTGCTCGACAGACTG
AAAGGAAGGGAACTGCCGCTGAAAGTGACCGTACCTTCAGAGCTGATTATTCGGGAAAGCTGCGGATTCAGCAAACGGAG
CTAA

Upstream 100 bases:

>100_bases
TTGAAAAAACTTATTTTTTTTAATATTGAAAACTTTTACCTTGTTTGTTATGATTTTTTTAGTAAAGTTTAGTGAATACG
GATTCCAAAGACAGGACGGG

Downstream 100 bases:

>100_bases
TGGTAGAATAAGGCGCTTTCCAAGGAGGTGACGCAAATGGATTTACTAAATTCCAGTAAAAAATGAAAGCGCTTTTTATT
CACCATTAAAATATCATAAT

Product: MsmR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKMATIKEIALQAKVSSTTVSRVLNHDQSLSVAPETRQRILDIAARLGYKSTRRRREVYASGSGESPRIGIVVCQSQEEE
LNDPYFYSIRQGIESECFERGAFITKFIQLSSIRSNQPVGDVDGLIVIGRINFAGLQQCMGALNNVVYINHTDNEELRDS
VVVDFEKATGRALNHLKSLGYTRIGYIGGREKEHFRISDQETSAIEIEDKRLTAFLEMAGSDNAKHIYIGEYSMQQGYEL
MKKALLEKNVPEAFFIASDSMAIGALRALRESGLKVPEDVAIVSFNGIEASEFANPPLTTVKVHTEEMGRTGVKLLLDRL
KGRELPLKVTVPSELIIRESCGFSKRS

Sequences:

>Translated_347_residues
MKMATIKEIALQAKVSSTTVSRVLNHDQSLSVAPETRQRILDIAARLGYKSTRRRREVYASGSGESPRIGIVVCQSQEEE
LNDPYFYSIRQGIESECFERGAFITKFIQLSSIRSNQPVGDVDGLIVIGRINFAGLQQCMGALNNVVYINHTDNEELRDS
VVVDFEKATGRALNHLKSLGYTRIGYIGGREKEHFRISDQETSAIEIEDKRLTAFLEMAGSDNAKHIYIGEYSMQQGYEL
MKKALLEKNVPEAFFIASDSMAIGALRALRESGLKVPEDVAIVSFNGIEASEFANPPLTTVKVHTEEMGRTGVKLLLDRL
KGRELPLKVTVPSELIIRESCGFSKRS
>Mature_347_residues
MKMATIKEIALQAKVSSTTVSRVLNHDQSLSVAPETRQRILDIAARLGYKSTRRRREVYASGSGESPRIGIVVCQSQEEE
LNDPYFYSIRQGIESECFERGAFITKFIQLSSIRSNQPVGDVDGLIVIGRINFAGLQQCMGALNNVVYINHTDNEELRDS
VVVDFEKATGRALNHLKSLGYTRIGYIGGREKEHFRISDQETSAIEIEDKRLTAFLEMAGSDNAKHIYIGEYSMQQGYEL
MKKALLEKNVPEAFFIASDSMAIGALRALRESGLKVPEDVAIVSFNGIEASEFANPPLTTVKVHTEEMGRTGVKLLLDRL
KGRELPLKVTVPSELIIRESCGFSKRS

Specific function: Repressor For Beta Galactosidase Alpha And Beta Subunits (Ebga And Ebgc). Binds Lactose As An Inducer. [C]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789456, Length=337, Percent_Identity=35.6083086053413, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1790369, Length=338, Percent_Identity=31.0650887573964, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787948, Length=352, Percent_Identity=28.125, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=25.9818731117825, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1786540, Length=368, Percent_Identity=26.3586956521739, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789202, Length=350, Percent_Identity=26.8571428571429, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788474, Length=335, Percent_Identity=25.9701492537313, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789068, Length=355, Percent_Identity=25.3521126760563, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI48994940, Length=339, Percent_Identity=25.6637168141593, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790689, Length=342, Percent_Identity=23.3918128654971, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38641; Mature: 38641

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMATIKEIALQAKVSSTTVSRVLNHDQSLSVAPETRQRILDIAARLGYKSTRRRREVYA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEE
SGSGESPRIGIVVCQSQEEELNDPYFYSIRQGIESECFERGAFITKFIQLSSIRSNQPVG
CCCCCCCEEEEEEECCCHHHCCCCCHHHHHHCHHHHHHHCCHHHHHHHHHHHCCCCCCCC
DVDGLIVIGRINFAGLQQCMGALNNVVYINHTDNEELRDSVVVDFEKATGRALNHLKSLG
CCCCEEEEEECCHHHHHHHHHHHCCEEEEECCCCHHHHHHEEEEEHHHHHHHHHHHHHCC
YTRIGYIGGREKEHFRISDQETSAIEIEDKRLTAFLEMAGSDNAKHIYIGEYSMQQGYEL
CEEEEECCCCCCCCEEECCCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHH
MKKALLEKNVPEAFFIASDSMAIGALRALRESGLKVPEDVAIVSFNGIEASEFANPPLTT
HHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHCCCCCCEE
VKVHTEEMGRTGVKLLLDRLKGRELPLKVTVPSELIIRESCGFSKRS
EEEEHHHHCHHHHHHHHHHHCCCCCCEEEECCHHHEEECCCCCCCCC
>Mature Secondary Structure
MKMATIKEIALQAKVSSTTVSRVLNHDQSLSVAPETRQRILDIAARLGYKSTRRRREVYA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEE
SGSGESPRIGIVVCQSQEEELNDPYFYSIRQGIESECFERGAFITKFIQLSSIRSNQPVG
CCCCCCCEEEEEEECCCHHHCCCCCHHHHHHCHHHHHHHCCHHHHHHHHHHHCCCCCCCC
DVDGLIVIGRINFAGLQQCMGALNNVVYINHTDNEELRDSVVVDFEKATGRALNHLKSLG
CCCCEEEEEECCHHHHHHHHHHHCCEEEEECCCCHHHHHHEEEEEHHHHHHHHHHHHHCC
YTRIGYIGGREKEHFRISDQETSAIEIEDKRLTAFLEMAGSDNAKHIYIGEYSMQQGYEL
CEEEEECCCCCCCCEEECCCCCCEEEEEHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHH
MKKALLEKNVPEAFFIASDSMAIGALRALRESGLKVPEDVAIVSFNGIEASEFANPPLTT
HHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHCCCCCCEE
VKVHTEEMGRTGVKLLLDRLKGRELPLKVTVPSELIIRESCGFSKRS
EEEEHHHHCHHHHHHHHHHHCCCCCCEEEECCHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]